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Journal of Neuro-Oncology
Published in: Journal of Neuro-Oncology 2/2017

01-01-2017 | Clinical Study

Mechanisms of post-radiation injury: cerebral microinfarction not a significant factor

Authors: J. A. Molad, D. T. Blumenthal, F. Bokstein, M. Findler, I. Finkel, N. M. Bornstein, S. Yust-Katz, E. Auriel

Published in: Journal of Neuro-Oncology | Issue 2/2017

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Abstract

Post-radiation leukoencephalopathy is characterized by cognitive impairment and white matter alternations on imaging. Cerebral small vessel disease (SVD) is one of several suggested etiologies. Cerebral microinfarction (CMI) is a recently described marker of SVD. We sought to examine the rate of CMI as a biomarker of ongoing ischemia among patients who underwent brain radiotherapy (RT). 110 patients treated with RT for primary or metastatic brain tumors were enrolled. A total of 685 brain MRI tests performed 1–108 months post-radiation were examined. The annual incidence of CMI was calculated. Only 2 definite CMI were found (2/685, 0.3 %). The calculated annual incidence of CMI was 0.11. This incidence is similar to the normal population, and lower than the reported incidence in patients with intracerebral hemorrhage or cognitive impairment. CMI incidence in patients treated with brain RT is similar to the general population. This finding suggests that post-radiation leukoencephalopathy and cognitive impairment are not due to active SVD solely but rather secondary to other causes such as inflammation, metabolic or direct cell damage.
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Metadata
Title
Mechanisms of post-radiation injury: cerebral microinfarction not a significant factor
Authors
J. A. Molad
D. T. Blumenthal
F. Bokstein
M. Findler
I. Finkel
N. M. Bornstein
S. Yust-Katz
E. Auriel
Publication date
01-01-2017
Publisher
Springer US
Published in
Journal of Neuro-Oncology / Issue 2/2017
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-016-2291-x

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