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01-06-2015 | Topic Review

Tumor bed radiosurgery: an emerging treatment for brain metastases

Authors: Mark J. Amsbaugh, Warren Boling, Shiao Woo

Published in: Journal of Neuro-Oncology | Issue 2/2015

Abstract

While typically used for treating small intact brain metastases, an increasing body of literature examining tumor bed directed stereotactic radiosurgery (SRS) is emerging. There are now over 1000 published cases treated with this approach, and the first prospective trial was recently published. The ideal sequencing of tumor bed SRS is unclear. Current approaches include, a neoadjuvant treatment before resection, alone as an adjuvant after resection, and following surgery combined with whole brain radiotherapy either as an adjuvant or salvage treatment. Based on available evidence, adjuvant stereotactic radiosurgery improves local control following surgery, reduces the number of patients who require whole brain radiotherapy, and is well tolerated. While results from published series vary, heterogeneity in both patient populations and methods of reporting results make comparisons difficult. Additional prospective data, including randomized trials are needed to confirm equivalent outcomes to the current standard of care. We review the current literature, identify areas of ongoing contention, and highlight ongoing studies.

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Title: Tumor bed radiosurgery: an emerging treatment for brain metastases
Authors: Mark J. Amsbaugh
Warren Boling
Shiao Woo
Publication date: 01-06-2015
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2015
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-1789-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tumor bed radiosurgery: an emerging treatment for brain metastases

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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