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01-05-2015 | Laboratory Investigation

MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2

Authors: Jie Sun, Guodong Zheng, Zhengtao Gu, Zhenhui Guo

Published in: Journal of Neuro-Oncology | Issue 3/2015

Abstract

It is suggested that microRNAs play important roles in the development of various cancers. Here, we showed that miR-137 is downregulated in glioblastoma (GBM) cell lines and that low levels of miR-137 are associated with a poor prognostic phenotype of GBM patients. Ectopic expression of miR-137 significantly inhibited GBM cell proliferation and angiogenesis. In addition, ectopic expression of miR-137 inhibited tumor growth and angiogenesis in a SCID mouse xenograft model. EZH2 was identified as a direct target of miR-137 by using luciferase reporter and Western blot assays, and EZH2 overexpression can rescue the inhibitory effect of miR-137 on cell proliferation and angiogenesis. Furthermore, tumor samples from GBM patients showed an inverse relationship between miR-137 and EZH2 levels. Our results suggest that miR-137 may serve as a biomarker in GBM, and the modulation of its activity may represent a novel therapeutic strategy for the treatment of GBM patients.

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Title: MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2
Authors: Jie Sun
Guodong Zheng
Zhengtao Gu
Zhenhui Guo
Publication date: 01-05-2015
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2015
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-1753-x

At a glance: The STEP trials

Springer Medicine

MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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