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01-06-2014 | Clinical Study

Relationship between survival and increased radiation dose to subventricular zone in glioblastoma is controversial

Authors: Olgun Elicin, Ebrar Inac, Esengul Kocak Uzel, Songul Karacam, Omer Erol Uzel

Published in: Journal of Neuro-Oncology | Issue 2/2014

Abstract

To test the hypothesis on prolonged survival in glioblastoma cases with increased subventricular zone (SVZ) radiation dose. Sixty glioblastoma cases were previously treated with adjuvant radiotherapy and Temozolamide. Ipsilateral, contralateral and bilateral SVZs were contoured and their doses were retrospectively evaluated. Median follow-up, progression free survival (PFS) and overall survival (OS) were 24.5, 8.5 and 19.3 months respectively. Log-rank tests showed a statistically significant correlation between contralateral SVZ (cSVZ) dose > 59.2 Gy (75th percentile) and poor median PFS (10.37 [95 % CI 8.37–13.53] vs 7.1 [95 % CI 3.5–8.97] months, p = 0.009). cSVZ dose > 59.2 Gy was associated with poor OS in the subgroup with subtotal resection/biopsy (HR: 4.83 [95 % CI 1.71–13.97], p = 0.004). High ipsilateral SVZ dose of > 62.25 Gy (75th percentile) was associated with poor PFS in both subgroups of high performance status (HR: 2.58 [95 % CI 1.03–6.05], p = 0.044) and SVZ without tumoral contact (HR: 10.57 [95 % CI 2.04–49], p = 0.008). The effect of high cSVZ dose on PFS lost its statistical significance in multivariate Cox regression analysis. We report contradictory results compared to previous publications. Changing the clinical practice based on retrospective studies which even do not indicate consistent results among each other will be dangerous. We need carefully designed prospective randomized studies to evaluate any impact of radiation to SVZ in glioblastoma.

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Title: Relationship between survival and increased radiation dose to subventricular zone in glioblastoma is controversial
Authors: Olgun Elicin
Ebrar Inac
Esengul Kocak Uzel
Songul Karacam
Omer Erol Uzel
Publication date: 01-06-2014
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2014
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-014-1424-3

At a glance: The STEP trials

Springer Medicine

Relationship between survival and increased radiation dose to subventricular zone in glioblastoma is controversial

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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