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01-01-2014 | Clinical Study

Retrospective evaluation of the outcomes of children with diffuse intrinsic pontine glioma treated with radiochemotherapy and valproic acid in a single center

Authors: Francisco Helder Cavalcante Felix, Orlandira Leite de Araujo, Karine Martins da Trindade, Nadia Mendonça Trompieri, Juvenia Bezerra Fontenele

Published in: Journal of Neuro-Oncology | Issue 2/2014

Abstract

Diffuse intrinsic pontine glioma is a pediatric oncologic disease with dismal prognosis and no effective treatment. Since 2007, our patients have been using valproic acid as prophylactic anticonvulsant. We have undertaken a retrospective study in order to evaluate the influence of valproate in the outcomes of children with this disease in our center. Patients were treated with weekly carboplatin and vincristine and received conformal radiotherapy, either concurrent or sequential. Event-free survival and overall survival of patients not treated with valproic acid were 6.5 and 7.8 months. Accelerated failure time model (a parametric multivariate regression test for time-to-failure data) showed a statistically significant superiority of the median event-free survival of treated patients (6.5 vs. 9.5 months in treated patients; HR 0.54–95 % CI 0.33–0.87; p < 0.05) and also of overall survival (7.8 vs. 13.4 months in treated patients; HR 0.60–95 % CI 0.37–0.98; p = 0.05).

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Title: Retrospective evaluation of the outcomes of children with diffuse intrinsic pontine glioma treated with radiochemotherapy and valproic acid in a single center
Authors: Francisco Helder Cavalcante Felix
Orlandira Leite de Araujo
Karine Martins da Trindade
Nadia Mendonça Trompieri
Juvenia Bezerra Fontenele
Publication date: 01-01-2014
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2014
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-013-1280-6

At a glance: The STEP trials

Springer Medicine

Retrospective evaluation of the outcomes of children with diffuse intrinsic pontine glioma treated with radiochemotherapy and valproic acid in a single center

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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