Top

Published in:

01-02-2009 | Laboratory Investigation - Human/Animal Tissue

Genetic characterization of adult infratentorial gliomas

Authors: Tomoru Miwa, Yuichi Hirose, Hikaru Sasaki, Eiji Ikeda, Kazunari Yoshida, Takeshi Kawase

Published in: Journal of Neuro-Oncology | Issue 3/2009

Abstract

Adult infratentorial gliomas are rare and have not been well studied. We therefore conducted genetic analysis of those tumors to see if there was any characteristic that could be relevant in clinical management and understanding of tumorigenesis. Nineteen adult infratentorial gliomas were analyzed for chromosomal aberration by comparative genomic hybridization, and for expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry. The most frequent chromosomal aberration was the gain of 7p, and five of the seven cerebellar or fourth ventricle malignant gliomas had that aberration. However, the gain of 7q, the characteristic abnormality of supratentorial astrocytomas commonly associated with the gaining of 7p, was observed only in 1 of 11 adult infratentorial astrocytic tumors. Combined losses of 1p and 19q, the genetic hallmark of oligodendroglioma, were not observed. Results of immunohistochemistry of p53 and EGFR were comparable to those reported in supratentorial gliomas. Our findings might suggest the presence of distinct tumorigenic pathway in adult infratentorial gliomas.

Cairncross JG, Ueki K, Zlatescu MC et al (1998) Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 90(19):1473–1479. doi:10.1093/jnci/90.19.1473 PubMedCrossRef

Sasaki H, Zlatescu MC, Betensky RA et al (2001) PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. Am J Pathol 159(1):359–367PubMed

Hirose Y, Aldape KD, Chang S et al (2003) Grade II astrocytomas are subgrouped by chromosome aberrations. Cancer Genet Cytogenet 142(1):1–7. doi:10.1016/S0165-4608(02)00791-4 PubMedCrossRef

Hirose Y, Aldape K, Bollen A et al (2001) Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups. Am J Pathol 158(3):1137–1143PubMed

Zlatescu MC, TehraniYazdi A, Sasaki H et al (2001) Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms. Cancer Res 61(18):6713–6715PubMed

Mueller W, Hartmann C, Hoffmann A et al (2002) Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. Am J Pathol 161(1):313–319PubMed

Kleihues P, Cavenee WK (eds) (2000) World Health Organization classification of tumors of the nervous system. IARC/WHO, Lyon

Hirose Y, Aldape K, Takahashi M et al (2001) Tissue microdissection and degenerate oligonucleotide primed polymerase chain reaction (DOP-PCR) is an effective method to analyze genetic aberrations in invasive tumors. J Mol Diagn 3(2):62–67PubMed

Henson JW, Hobbs W, Chakravarti A et al (2005) Alterations in p53, p21, and MIB-1 labeling index in primary human astrocytomas following radiation therapy. J Neurooncol 74(2):151–154. doi:10.1007/s11060-004-6911-5 PubMedCrossRef

10.

Reifenberger J, Ring GU, Gies U et al (1996) Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression. J Neuropathol Exp Neurol 55(7):822–831. doi:10.1097/00005072-199607000-00007 PubMedCrossRef

11.

Hirose Y, Yoshida K (2006) Chromosomal abnormalities subdivide neuroepithelial tumors into clinically relevant groups. Keio J Med 55(2):52–58. doi:10.2302/kjm.55.52 PubMedCrossRef

12.

Djalilian HR, Hall WA (1998) Malignant gliomas of the cerebellum: an analytical review. J Neurooncol 36:247–257. doi:10.1023/A:1005704006244 PubMedCrossRef

Title: Genetic characterization of adult infratentorial gliomas
Authors: Tomoru Miwa
Yuichi Hirose
Hikaru Sasaki
Eiji Ikeda
Kazunari Yoshida
Takeshi Kawase
Publication date: 01-02-2009
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2009
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-008-9714-2

At a glance: The STEP trials

Springer Medicine

Genetic characterization of adult infratentorial gliomas

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2009

Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to γ-radiation

Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study

Recurrent lymphomatous meningitis treated with intra-CSF rituximab and liposomal ara-C

WHO Grade II and III supratentorial hemispheric ependymomas in adults: case series and review of treatment options

Modeling the effects of resection, radiation and chemotherapy in glioblastoma

DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response