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01-12-2008 | Clinical study - Patient Study

Anticoagulation for radiation-induced neurotoxicity revisited

Authors: Caroline Happold, Ulrike Ernemann, Patrick Roth, Wolfgang Wick, Michael Weller, Friederike Schmidt

Published in: Journal of Neuro-Oncology | Issue 3/2008

Abstract

No effective treatment for delayed radiation-induced neurotoxicity has been established. Its natural course is highly variable, but spontaneous recovery has been well documented. Here we report our experience with therapeutic anticoagulation in patients with cerebral lesions (n = 3), cranial nerve lesions (n = 1) or myelopathy (n = 4) attributed to irradiation. Two of three patients with cerebral lesions and the patient with cranial nerve lesions showed a minor improvement of clinical symptoms. In contrast, none of the patients with radiation myelopathy improved. No patient suffered hemorrhage or other adverse effects of anticoagulation. Overall, anticoagulation therapy demonstrates only modest activity for delayed radiation-induced neurotoxicity in this small case series.

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Title: Anticoagulation for radiation-induced neurotoxicity revisited
Authors: Caroline Happold
Ulrike Ernemann
Patrick Roth
Wolfgang Wick
Michael Weller
Friederike Schmidt
Publication date: 01-12-2008
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2008
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-008-9674-6

At a glance: The STEP trials

Springer Medicine

Anticoagulation for radiation-induced neurotoxicity revisited

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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