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01-04-2007 | Clinical–Patient Studies

A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma

Authors: Marc C. Chamberlain, Lisa Chalmers

Published in: Journal of Neuro-Oncology | Issue 2/2007

Abstract

There is no standard of care for elderly patients (age ≥ 70 years) with newly diagnosed glioblastoma (GBM). In 15 consecutive patients (median age 79 years) treated with temozolomide (TMZ) (42 days on; 14 days off), median survival was 6 months (range 4–14 months). This pilot study suggests that low dose daily TMZ may represent an alternative and equally effective treatment to more traditionally administered radiotherapy.

Stupp R, Mason WP, van den Bent M et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Eng J Med 352:987–996CrossRef

Mirimanoff R-O, Gorlia T, Mason W et al (2006) Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial. J Clin Oncol 24(16):2563–2569PubMedCrossRef

Glantz M, Chamberlain M, Liu Q, Litofsky NS, Recht LD (2003) Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer 97:2262–2266PubMedCrossRef

Macdonald DR, Cascino TL, Schold SC et al (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277–1280PubMed

Talarico L, Chen G, Pazdur R. (2004) Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US food and drug administration. J Clin Oncol 22:4626–4631PubMedCrossRef

Ohgaki H, Dessen P, Jourde B et al (2005) Genetic pathways to glioblastoma: a population-based study. Cancer Res 64:6892–6899CrossRef

Chang SM, Parney IF, Huang W, et al. (2005) Glioma outcomes project investigators. Patterns of care for adults with newly diagnosed malignant glioma. JAMA 2; 293(5):557–564

Rao W, Brasher PM, Bauman G et al (2004) Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol 22(9):1583–1588CrossRef

Buttolo L, Giunta F, Ferrari VD et al (2006) Alternative schedules of adjuvant temozolomide in glioblastoma multiforme; a 6-year experience. Alternative schedules of TMZ for newly diagnosed GBM. Proc ASCO 24(18S):60s (abstract)

10.

Hegi M, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. NEJM 352(10):997–1003PubMedCrossRef

Title: A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma
Authors: Marc C. Chamberlain
Lisa Chalmers
Publication date: 01-04-2007
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2007
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-006-9269-z

At a glance: The STEP trials

Springer Medicine

A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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