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Metabolic Brain Disease
Published in: Metabolic Brain Disease 4/2017

01-08-2017 | Original Article

Correlation of rs9331888 polymorphism with Alzheimer’s disease among Caucasian and Chinese populations: a meta-analysis and systematic review

Authors: Bin Zhu, Rui Min Wang, Jian Ting Wang, Rui Ling Chen, Yan Fei Zheng, Lei Zhang, Zhi Gang Zhao

Published in: Metabolic Brain Disease | Issue 4/2017

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Abstract

Clusterin polymorphism (rs9331888) was reported to be associated with the susceptibility to alzheimer’s disease (AD). Nevertheless, the results were inconclusive. To derive a more precise estimation of this association, this meta-analysis was conducted. We’ve conducted a comprehensive search of PubMed, Embase, CNKI and AlzGene database for case-control studies published throughout October, 2016 that evaluated the role of rs9331888 gene variants in AD patients. Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated to assess the strength of associations between the rs9331888/C > G polymorphism and AD disease. A total of 9 studies were enrolled in the Meta Analysis. The overall analysis revealed a significant association between the rs9331888/C > G polymorphism and AD disease in the recessive model (GG vs. GC + CC: OR = 1.11, 95% CI: 1.05–1.18; P < 0.01). Sub-group analysis revealed that the Caucasian populations which with recessive model (GG vs. GC + CC: OR = 1.12, 95% CI: 1.06–1.2; P < 0.01) were dramatically related to AD, while no significant association was found in the Chinese populations among the five genetic models. Our meta-analysis demonstrated that the rs9331888/C > G polymorphism in the clusterin gene might contribute to AD susceptibility especially in Caucasian populations. Whereas the relationship of the polymorphism to the disease in Chinese populations was still in controversial. Additional well-designed studies, with larger sample sizes, are required to further elucidate this association.
Literature
Alaylioglu M, Gezen-Ak D, Dursun E, Bilgic B, Hanagasi H, Ertan T, Gurvit H, Emre M, Eker E, Uysal O, Yilmazer S (2016) The association between clusterin and APOE polymorphisms and late-onset Alzheimer disease in a Turkish cohort. J Geriatr Psychiatry Neurol 29(4):221–226CrossRefPubMed
Alzheimer's disease facts and figures (2015) 2015 Alzheimer's disease facts and figures. Alzheimers Dement 11(3):332–384CrossRef
Bettens K, Vermeulen S, Van Cauwenberghe C, Heeman B, Asselbergh B, Robberecht C, Engelborghs S, Vandenbulcke M, Vandenberghe R, De Deyn PP, Cruts M, Van Broeckhoven C, Sleegers K (2015) Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations. Mol Neurodegener 10:30CrossRefPubMedPubMedCentral
Bodily PM, Fujimoto MS, Page JT, Clement MJ, Ebbert MT, Ridge PG (2016) A novel approach for multi-SNP GWAS and its application in Alzheimer's disease. BMC Bioinf 17(Suppl 7):268CrossRef
Cuyvers E, Sleegers K (2016) Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond. Lancet Neurol 15(8):857–868CrossRefPubMed
Gu H, Wei X, Chen S, Kurz A, Muller U, Gasser T, Dodel RC, Farlow MR, Du Y (2011) Association of clusterin gene polymorphisms with late-onset Alzheimer's disease. Dement Geriatr Cogn Disord 32(3):198–201CrossRefPubMed
Jiao B, Liu X, Zhou L, Wang MH, Zhou Y, Xiao T, Zhang W, Sun R, Waye MM, Tang B, Shen L (2015) Polygenic analysis of late-onset Alzheimer's disease from mainland China. PLoS One 10(12):e144898
Kamboh MI, Minster RL, Demirci FY, Ganguli M, DeKosky ST, Lopez OL, Barmada MM (2012) Association of CLU and PICALM variants with Alzheimer's disease. Neurobiol Aging 33(3):518–521CrossRefPubMed
Lacour A, Espinosa A, Louwersheimer E, Heilmann S, Hernandez I, Wolfsgruber S, Fernandez V, Wagner H, Rosende-Roca M, Mauleon A, Moreno-Grau S, Vargas L, Pijnenburg YA, Koene T, Rodriguez-Gomez O, Ortega G, Ruiz S, Holstege H, Sotolongo-Grau O, Kornhuber J, Peters O, Frolich L, Hull M, Ruther E, Wiltfang J, Scherer M, Riedel-Heller S, Alegret M, Nothen MM, Scheltens P, Wagner M, Tarraga L, Jessen F, Boada M, Maier W, van der Flier WM, Becker T, Ramirez A, Ruiz A (2017) Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment. Mol Psychiatry 22(1):153–160
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fievet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossu P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanche H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alperovitch A, Lathrop M, Amouyel P (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41(10):1094–1099CrossRefPubMed
Li X, Ma Y, Wei X, Li Y, Wu H, Zhuang J, Zhao Z (2014) Clusterin in Alzheimer's disease: a player in the biological behavior of amyloid-beta. Neurosci Bull 30(1):162–168CrossRefPubMed
Lidstrom AM, Bogdanovic N, Hesse C, Volkman I, Davidsson P, Blennow K (1998) Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease. Exp Neurol 154(2):511–521CrossRefPubMed
Liu, XY (2014). Association analysis of late onset Alzheimer’s disease and Susceptibility genes in Chinese Han population, Central South University
Lu SJ, Li HL, Sun YM, Liu ZJ, Yang P, Wu ZY (2014) Clusterin variants are not associated with southern Chinese patients with Alzheimer's disease. Neurobiol Aging 35(11):2656–2659CrossRefPubMed
Mengel-From J, Thinggaard M, Lindahl-Jacobsen R, McGue M, Christensen K, Christiansen L (2013) CLU genetic variants and cognitive decline among elderly and oldest old. PLoS One 8(11):e79105CrossRefPubMedPubMedCentral
Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM (2016) Alzheimer's disease. Lancet 388(10043):505–517CrossRefPubMed
Shuai P, Liu Y, Lu W, Liu Q, Li T, Gong B (2015) Genetic associations of CLU rs9331888 polymorphism with Alzheimer's disease: a meta-analysis. Neurosci Lett 591:160–165CrossRefPubMed
Tan L, Wang HF, Tan MS, Tan CC, Zhu XC, Miao D, Yu WJ, Jiang T, Tan L, Yu JT (2016) Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts. Sci Rep 6:26027CrossRefPubMedPubMedCentral
Thambisetty M, Beason-Held LL, An Y, Kraut M, Nalls M, Hernandez DG, Singleton AB, Zonderman AB, Ferrucci L, Lovestone S, Resnick SM (2013) Alzheimer risk variant CLU and brain function during aging. Biol Psychiatry 73(5):399–405CrossRefPubMed
Wang, B. (2014). Association of polymorphisms in Alzheimer’S disease and CLU and clusterin in people with mild cognitive impairment, Fudan University
Xing YY, Yu JT, Cui WZ, Zhong XL, Wu ZC, Zhang Q, Tan L (2012) Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease. J Alzheimers Dis 29(3):515–519PubMed
Yu JT, Li L, Zhu QX, Zhang Q, Zhang W, Wu ZC, Guan J, Tan L (2010) Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease. Clin Chim Acta 411(19–20):1516–1519CrossRefPubMed
Zhang S, Li X, Ma G, Jiang Y, Liao M, Feng R, Zhang L, Liu J, Wang G, Zhao B, Jiang Q, Li K, Liu G (2016) CLU rs9331888 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian but not east Asian populations. Mol Neurobiol 53(3):1446–1451CrossRefPubMed
Zhang S, Wang XB, Han YD, Wang C, Zhou Y, Zheng F (2017) Certain polymorphisms in SP110 Gene confer susceptibility to tuberculosis: a comprehensive review and updated meta-analysis. Yonsei Med J 58(1):165–173CrossRefPubMed
Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger JJ, Zerbinatti C (2014) Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein tau in Alzheimer's disease. PLoS One 9(7):e103187CrossRefPubMedPubMedCentral
Metadata
Title
Correlation of rs9331888 polymorphism with Alzheimer’s disease among Caucasian and Chinese populations: a meta-analysis and systematic review
Authors
Bin Zhu
Rui Min Wang
Jian Ting Wang
Rui Ling Chen
Yan Fei Zheng
Lei Zhang
Zhi Gang Zhao
Publication date
01-08-2017
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 4/2017
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-017-9957-8

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