Top

Published in:

01-06-2018 | Original Article

The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats

Authors: Yousef Baghcheghi, Farimah Beheshti, Mohammad Naser Shafei, Hossein Salmani, Hamid Reza Sadeghnia, Mohammad Soukhtanloo, Akbar Anaeigoudari, Mahmoud Hosseini

Published in: Metabolic Brain Disease | Issue 3/2018

Abstract

The effects of vitamin E (Vit E) on brain derived neurotrophic factor (BDNF) and brain tissues oxidative damage as well as on learning and memory impairments in juvenile hypothyroid rats were examined. The rats were grouped as: (1) Control; (2) Propylthiouracil (PTU); (3) PTU-Vit E and (4) Vit E. PTU was added to their drinking water (0.05%) during 6 weeks. Vit E (20 mg/kg) was daily injected (IP). Morris water maze (MWM) and passive avoidance (PA) were carried out. The animals were deeply anesthetized and the brain tissues were removed for biochemical measurements. PTU increased the escape latency and traveled path in MWM (P < 0.001). It also shortened the latency to enter the dark compartment of PA as well as the time spent in the target quadrant in probe trial of MWM (P < 0.01-P < 0.001). All the effects of PTU were reversed by Vit E (P < 0.01-P < 0.001). PTU administration attenuated thiol and BDNF content as well as the activities of superoxide dismutase (SOD) and catalase (CAT) in the brain tissues while increased molondialdehyde (MDA). Moreover, Vit E improved BDNF, thiol, SOD and CAT while diminished MDA. The results of the present study showed that Vit E improved BDNF and prevented from brain tissues oxidative damage as well as learning and memory impairments in juvenile hypothyroid rats.

Abedelhaffez A, Hassan A (2013) Brain derived neurotrophic factor and oxidative stress index in pups with developmental hypothyroidism: neuroprotective effects of selenium. Acta Physiol Hung 100(2):197–210. https://doi.org/10.1556/APhysiol.100.2013.2.7 CrossRefPubMed

Ahmad M, Saleem S, Ahmad AS, Yousuf S, Ansari MA, Khan MB, Ishrat T, Chaturvedi RK, Agrawal AK, Islam F (2005) Ginkgo Biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences. J Neurochem 93(1):94–104. https://doi.org/10.1111/j.1471-4159.2005.03000.x CrossRefPubMed

Ahmed OM, El-Gareib A, El-Bakry A, El-Tawab SA, Ahmed R (2008) Thyroid hormones states and brain development interactions. Int J Dev Neurosci 26(2):147–209. https://doi.org/10.1016/j.ijdevneu.2007.09.011 CrossRefPubMed

Ahmed O, Ahmed R, El-Gareib A, El-Bakry A, Abd El-Tawab S (2012) Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II—the developmental pattern of neurons in relation to oxidative stress and antioxidant defense system. Int J Dev Neurosci 30(6):517–537. https://doi.org/10.1016/j.ijdevneu.2012.04.005 CrossRefPubMed

Altar CA, Boylan CB, Fritsche M, Jones BE, Jackson C, Wiegand SJ, Lindsay RM, Hyman C (1994) Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. J Neurochem 63(3):1021–1032CrossRefPubMed

Alva-Sanchez C, Ortiz-Butron R, Pacheco-Rosado J (2004) Kainic acid does not affect CA3 hippocampal region pyramidal cells in hypothyroid rats. Brain Res Bull 63(2):167–171. https://doi.org/10.1016/j.brainresbull.2004.02.002 CrossRefPubMed

Alzoubi KH, Gerges NZ, Aleisa AM, Alkadhi KA (2009) Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: behavioral, electrophysiological, and molecular studies. Hippocampus 19(1):66–78. https://doi.org/10.1002/hipo.20476 CrossRefPubMed

An L, Zhang T (2014) Vitamins C and E reverse melamine-induced deficits in spatial cognition and hippocampal synaptic plasticity in rats. Neurotoxicology 44:132–139. https://doi.org/10.1016/j.neuro.2014.06.009 CrossRefPubMed

Ansari MA, Ahmad AS, Ahmad M, Salim S, Yousuf S, Ishrat T, Islam F (2004) Selenium protects cerebral ischemia in rat brain mitochondria. Biol Trace Elem Res 101(1):73–86. https://doi.org/10.1385/BTER:101:1:73 CrossRefPubMed

Ateşşahin A, Yilmaz S, Karahan I, Pirinçci I, Taşdemir B (2005) The effects of vitamin E and selenium on cypermethrin-induced oxidative stress in rats. Turk J Vet Anim Sci 29(2):385–391

Barradas PC, Ferraz AS, Ferreira AA, Daumas RP, Moura EG (2000) 2'3'Cyclic nucleotide 3'phosphodiesterase immunohistochemistry shows an impairment on myelin compaction in hypothyroid rats. Int J Dev Neurosci 18(8):887–892. https://doi.org/10.1016/S0736-5748(00)00028-9 CrossRefPubMed

Baskol G, Atmaca H, Tanriverdi F, Baskol M, Kocer D, Bayram F (2007) Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment. Exp Clin Endocrinol Diabetes 115(8):522–526. https://doi.org/10.1055/s-2007-981457 CrossRefPubMed

Baydas G, Canatan H, Turkoglu A (2002) Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. J Pineal Res 32(4):225–230. https://doi.org/10.1034/j.1600-079X.2002.01856.x CrossRefPubMed

Beheshti F, Hosseini M, Shafei MN, Soukhtanloo M, Ghasemi S, Vafaee F, Zarepoor L (2017a) The effects of Nigella Sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats. Nutr Neurosci 20(1):49–59. https://doi.org/10.1179/1476830514Y.0000000144 PubMedCrossRef

Beheshti F, Karimi S, Vafaee F, Shafei MN, Sadeghnia HR, Hadjzadeh MAR, Hosseini M (2017b) The effects of vitamin C on hypothyroidism-associated learning and memory impairment in juvenile rats. Metab Brain Dis 32(3):703–715. https://doi.org/10.1007/s11011-017-9954-y CrossRefPubMed

Bernal J, Guadaño-Ferraz A, Morte B (2003) Perspectives in the study of thyroid hormone action on brain development and function. Thyroid 13(11):1005–1012. https://doi.org/10.1089/105072503770867174 CrossRefPubMed

Bhanja S, Chainy G (2010) PTU-induced hypothyroidism modulates antioxidant defence status in the developing cerebellum. Int J Dev Neurosci 28(3):251–262. https://doi.org/10.1016/j.ijdevneu.2010.01.005 CrossRefPubMed

Boutahar N, Reynaud E, Lassabliere F, Borg J (2010) Brain-derived neurotrophic factor inhibits cell cycle reentry but not endoplasmic reticulum stress in cultured neurons following oxidative or excitotoxic stress. J Neurosci Res 88(10):2263–2271. https://doi.org/10.1002/jnr.22384 CrossRefPubMed

Broedel O, Eravci M, Fuxius S, Smolarz T, Jeitner A, Grau H, Stoltenburg-Didinger G, Plueckhan H, Meinhold H, Baumgartner A (2003) Effects of hyper-and hypothyroidism on thyroid hormone concentrations in regions of the rat brain. Am J Physiol Endocrinol Metab 285(3):E470–EE80. https://doi.org/10.1152/ajpendo.00043.2003 CrossRefPubMed

Cano-Europa E, Pérez-Severiano F, Vergara P, Ortiz-Butrón R, Ríos C, Segovia J, Pacheco-Rosado J (2008 Sep) Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of rat. Metab Brain Dis 23(3):275–287. https://doi.org/10.1007/s11011-008-9099-0 CrossRefPubMed

Chakraborty G, Magagna-Poveda A, Parratt C, Umans JG, MacLusky NJ, Scharfman HE (2012) Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU). Endocrinology 153(3):1311–1316. https://doi.org/10.1210/en.2011-1437 CrossRefPubMedPubMedCentral

Cortés C, Eugenin E, Aliaga E, Carreño LJ, Bueno SM, Gonzalez PA, Gayol S, Naranjo D, Noches V, Marassi MP (2012) Hypothyroidism in the adult rat causes incremental changes in brain-derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density. Thyroid 22(9):951–963. https://doi.org/10.1089/thy.2010.0400 CrossRefPubMedPubMedCentral

Das K, Chainy GB (2001) Modulation of rat liver mitochondrial antioxidant defence system by thyroid hormone. Biochim Biophys Acta 1537(1):1–13. https://doi.org/10.1016/S0925-4439(01)00048-5 CrossRefPubMed

Das K, Chainy G (2004) Thyroid hormone influences antioxidant defense system in adult rat brain. Neurochem Res 29(9):1755–1766. https://doi.org/10.1023/B:NERE.0000035812.58200.a9 CrossRefPubMed

Dasgupta A, Das S, Sarkar PK (2005) Thyroid hormone stimulates γ-glutamyl transpeptidase in the developing rat cerebra and in astroglial cultures. J Neurosci Res 82(6):851–857. https://doi.org/10.1002/jnr.20657 CrossRefPubMed

Dasgupta A, Das S, Sarkar PK (2007) Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Free Radic Biol Med 42(5):617–626. https://doi.org/10.1016/j.freeradbiomed.2006.11.030 CrossRefPubMed

Davidson B, Soodak M, Neary J, Strout H, Kieffer J, Mover H et al (1978) The irreversible inactivation of thyroid peroxidase by methylmercaptoimidazole, thiouracil, and propylthiouracil in vitro and its relationship to in vivo findings. Endocrinology 103(3):871–882. https://doi.org/10.1210/endo-103-3-871 CrossRefPubMed

Debnath T, Park P-J, Nath NCD, Samad NB, Park HW, Lim BO (2011) Antioxidant activity of Gardenia Jasminoides Ellis fruit extracts. Food Chem 128(3):697–703. https://doi.org/10.1016/j.foodchem.2011.03.090 CrossRef

Deng S, Hou G, Xue Z, Zhang L, Zhou Y, Liu C, Liu Y, Li Z (2015) Vitamin E isomer δ-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel. Neurosci Lett 585:166–170. https://doi.org/10.1016/j.neulet.2014.11.031 CrossRefPubMed

Di Mascio P, Murphy ME, Sies H (1991) Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 53(1):194S–200SCrossRefPubMed

Ebuehi O, Ogedegbe R, Ebuehi O (2012) Oral Administration of Vitamin C and Vitamin E amelioratesLead-induced hepatotoxicity and oxidative stress in the rat brain. Nigerian quarterly journal of hospital medicine 22(2):85–90PubMed

Eichenbaum H (2004) Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron 44(1):109–120. https://doi.org/10.1016/j.neuron.2004.08.028 CrossRefPubMed

Fahim MA, Tariq S, Adeghate E (2013) Vitamin E modifies the ultrastructure of testis and epididymis in mice exposed to lead intoxication. Ann Anat 195(3):272–277. https://doi.org/10.1016/j.aanat.2012.11.001 CrossRefPubMed

Farrokhi E, Hosseini M, Beheshti F, Vafaee F, Hadjzadeh MA-R, Dastgheib SS (2014) Brain tissues oxidative damage as a possible mechanism of deleterious effects of Propylthiouracil-induced hypothyroidism on learning and memory in neonatal and juvenile growth in rats. Basic Clin Neurosci 5(4):285–294PubMedPubMedCentral

Fukui K, Onodera K, Shinkai T, Suzuki S, Urano S (2001) Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann N Y Acad Sci 928(1):168–175CrossRefPubMed

Fukui K, Omoi NO, Hayasaka T, Shinnkai T, Suzuki S, Abe K, Urano S (2002) Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Ann N Y Acad Sci 959(1):275–284. https://doi.org/10.1111/j.1749-6632.2002.tb02099.x CrossRefPubMed

Fukui K, Takatsu H, Shinkai T, Suzuki S, Abe K, Urano S (2005) Appearance of amyloid β-like substances and delayed-type apoptosis in rat hippocampus CA1 region through aging and oxidative stress. J Alzheimers Dis 8(3):299–309. https://doi.org/10.3233/JAD-2005-8309 CrossRefPubMed

Gerges NZ, Alzoubi KH, Park CR, Diamond DM, Alkadhi KA (2004) Adverse effect of the combination of hypothyroidism and chronic psychosocial stress on hippocampus-dependent memory in rats. Behav Brain Res 155(1):77–84. https://doi.org/10.1016/j.bbr.2004.04.003 CrossRefPubMed

Gómez-Pinilla F (2008) Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci 9(7):568–578. https://doi.org/10.1038/nrn2421 CrossRefPubMedPubMedCentral

Gorski J, Balogh S, Wehner J, Jones K (2003) Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 121(2):341–354. https://doi.org/10.1016/S0306-4522(03)00426-3 CrossRefPubMed

Hosseini M, Dastghaib SS, Rafatpanah H, Hadjzadeh MA, Nahrevanian H, Farrokhi I (2010a) Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth. Clinics (Sao Paulo) 65(11):1175–1181. https://doi.org/10.1590/S1807-59322010001100021 CrossRef

Hosseini M, Hadjzadeh MA-R, Derakhshan M, Havakhah S, Rassouli FB, Rakhshandeh H, Saffarzadeh F (2010b) The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze. Arch Pharm Res 33(3):463–468. https://doi.org/10.1007/s12272-010-0317-z CrossRefPubMed

Hosseini M, Shafei MN, Safari V, Taiarani Z, Kafami Ladani M, Sadeghian R (2012) The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats. Nat Prod Res 26(16):1544–1548. https://doi.org/10.1080/14786419.2011.566223 CrossRefPubMed

Johnson RA, Mitchell GS (2003) Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain. Brain Res 983(1):108–114. https://doi.org/10.1016/S0006-8993(03)03039-7 CrossRefPubMed

Jolitha A, Subramanyam M, Devi SA (2006) Modification by vitamin E and exercise of oxidative stress in regions of aging rat brain: studies on superoxide dismutase isoenzymes and protein oxidation status. Exp Gerontol 41(8):753–763. https://doi.org/10.1016/j.exger.2006.04.007 CrossRefPubMed

Karimi SA, Salehi I, Komaki A, Sarihi A, Zarei M, Shahidi S (2013) Effect of high-fat diet and antioxidants on hippocampal long-term potentiation in rats: an in vivo study. Brain Res 1539:1–6. https://doi.org/10.1016/j.brainres.2013.09.029 CrossRefPubMed

Khanna S, Roy S, Ryu H, Bahadduri P, Swaan PW, Ratan RR, Sen CK (2003) Molecular basis of vitamin E action tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem 278(44):43508–43515. https://doi.org/10.1074/jbc.M307075200 CrossRefPubMedPubMedCentral

Koibuchi N (2008) The role of thyroid hormone on cerebellar development. Cerebellum 7(4):530–533. https://doi.org/10.1007/s12311-008-0069-1 CrossRefPubMed

Kundu S, Pramanik M, Roy S, De J, Biswas A, Ray AK (2006) Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat. Life Sci 79(15):1450–1455. https://doi.org/10.1016/j.lfs.2006.04.006 CrossRefPubMed

Lasley SM, Gilbert M (2011) Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates. Neurotoxicol Teratol 33(4):464–472. https://doi.org/10.1016/j.ntt.2011.04.001 CrossRefPubMed

Madesh M, Balasubramanian KA (1998) Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Indian J Biochem Biophys 35(3):184–188PubMed

Mattson MP, Maudsley S, Martin B (2004) BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27(10):589–594. https://doi.org/10.1016/j.tins.2004.08.001 CrossRefPubMed

Mitchell JJ, Paiva M, Heaton MB (1999) The antioxidants vitamin E and β-carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures. Alcohol 17(2):163–168. https://doi.org/10.1016/S0741-8329(98)00051-2 CrossRefPubMed

Nakashima H, Ishihara T, Yokota O, Terada S, Trojanowski JQ, Lee VM-Y, Kuroda S (2004) Effects of α-tocopherol on an animal model of tauopathies. Free Radic Biol Med 37(2):176–186. https://doi.org/10.1016/j.freeradbiomed.2004.04.037 CrossRefPubMed

Numakawa Y, Numakawa T, Matsumoto T, Yagasaki Y, Kumamaru E, Kunugi H, Taguchi T, Niki E (2006) Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J Neurochem 97(4):1191–1202. https://doi.org/10.1111/j.1471-4159.2006.03827.x CrossRefPubMed

Numakawa T, Suzuki S, Kumamaru E, Adachi N, Richards M, Kunugi H (2010) BDNF function and intracellular signaling in neurons. Histol Histopathol 25(2):237–258. https://doi.org/10.14670/HH-25.237 PubMedCrossRef

Oppenheimer JH, Schwartz HL (1997) Molecular basis of thyroid hormone-dependent brain development 1. Endocr Rev 18(4):462–475. https://doi.org/10.1210/edrv.18.4.0309 PubMedCrossRef

Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A (2004) α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47(6):904–915. https://doi.org/10.1016/j.neuropharm.2004.06.029 CrossRefPubMed

Patra R, Swarup D, Dwivedi S (2001) Antioxidant effects of α tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 162(2):81–88. https://doi.org/10.1016/S0300-483X(01)00345-6 CrossRefPubMed

Pazdro R, Burgess JR (2012) Differential effects of α-tocopherol and N-acetyl-cysteine on advanced glycation end product-induced oxidative damage and neurite degeneration in SH-SY5Y cells. Biochim Biophys Acta 1822(4):550–556. https://doi.org/10.1016/j.bbadis.2012.01.003 CrossRefPubMed

Pourganji M, Hosseini M, Soukhtanloo M, Zabihi H, Hadjzadeh MA (2014) Protective role of endogenous ovarian hormones against learning and memory impairments and brain tissues oxidative damage induced by lipopolysaccharide. Iran Red Crescent Med J 16(3):e13954. https://doi.org/10.5812/ircmj.13954 CrossRefPubMedPubMedCentral

Rahaman SO, Ghosh S, Mohanakumar K, Das S, Kumar Sarkar P (2001) Hypothyroidism in the developing rat brain is associated with marked oxidative stress and aberrant intraneuronal accumulation of neurofilaments. Neurosci Res 40(3):273–279. https://doi.org/10.1016/S0168-0102(01)00237-1 CrossRefPubMed

Rahman A, Khan KM, Al-Khaledi G, Khan I, Al-Shemary T (2012) Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology 33(3):370–383. https://doi.org/10.1016/j.neuro.2012.02.014 CrossRefPubMed

Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC (1993) Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328(20):1450–1456. https://doi.org/10.1056/NEJM199305203282004 CrossRefPubMed

Squire LR (2009) Memory and brain systems: 1969–2009. J Neurosci 29(41):12711–12716. https://doi.org/10.1523/JNEUROSCI.3575-09.2009 CrossRefPubMedPubMedCentral

Sui L, Li B-M (2010) Effects of perinatal hypothyroidism on regulation of reelin and brain-derived neurotrophic factor gene expression in rat hippocampus: role of DNA methylation and histone acetylation. Steroids 75(12):988–997. https://doi.org/10.1016/j.steroids.2010.06.005 CrossRefPubMed

Sui L, Wang F, Li B (2006) Adult-onset hypothyroidism impairs paired-pulse facilitation and long-term potentiation of the rat dorsal hippocampo-medial prefrontal cortex pathway in vivo. Brain Res 1096(1):53–60. https://doi.org/10.1016/j.brainres.2006.04.042 CrossRefPubMed

Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, Praticò D (2004) Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer’s disease. The FASEB J 18(2):323–325. https://doi.org/10.1096/fj.03-0961fje CrossRefPubMed

Takatsu H, Owada K, Abe K, Nakano M, Urano S (2009) Effect of vitamin E on learning and memory deficit in aged rats. J Nutr Sci Vitaminol 55(5):389–393. https://doi.org/10.3177/jnsv.55.389 CrossRefPubMed

Thompson CC, Potter GB (2000) Thyroid hormone action in neural development. Cereb Cortex 10(10):939–945. https://doi.org/10.1093/cercor/10.10.939 CrossRefPubMed

Torun AN, Kulaksizoglu S, Kulaksizoglu M, Pamuk BO, Isbilen E, Tutuncu NB (2009) Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clin Endocrinol 70(3):469–474. https://doi.org/10.1111/j.1365-2265.2008.03348.x CrossRef

Tuzcu M, Baydas G (2006) Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats. Eur J Pharmacol 537(1):106–110. https://doi.org/10.1016/j.ejphar.2006.03.024 CrossRefPubMed

Vafaee F, Hosseini M, Sadeghinia HR, Hadjzadeh MA, Soukhtanloo M, Rahimi M (2014) The effects of soy extract on spatial learning and memory damage induced by global ischemia in ovariectomised rats. Malays J Med Sci 21(3):19–30PubMedPubMedCentral

Vaynman S, Ying Z, Wu A, Gomez-Pinilla F (2006) Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity. Neuroscience 139(4):1221–1234. https://doi.org/10.1016/j.neuroscience.2006.01.062 CrossRefPubMed

Veinbergs I, Mallory M, Sagara Y, Masliah E (2000) Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoproteinE-deficient mice. Eur J Neurosci 12(12):4541–4546PubMed

Venditti P, Di Meo S (2006) Thyroid hormone-induced oxidative stress. Cell Mol Life Sci CMLS 63(4):414–434. https://doi.org/10.1007/s00018-005-5457-9 CrossRefPubMed

Venditti P, Balestrieri M, Di Meo S, De Leo T (1997) Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues. J Endocrinol 155(1):151–157. https://doi.org/10.1677/joe.0.1550151 CrossRefPubMed

Wilcoxon JS, Nadolski GJ, Samarut J, Chassande O, Redei EE (2007) Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor α. Behav Brain Res 177(1):109–116. https://doi.org/10.1016/j.bbr.2006.10.030 CrossRefPubMed

Wu A, Ying Z, Gomez-Pinilla F (2004) The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 19(7):1699–1707. https://doi.org/10.1111/j.1460-9568.2004.03246.x CrossRefPubMed

Wu A, Ying Z, Gomez-Pinilla F (2009) Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats. Neurorehabil Neural Repair 24(3):290–298PubMedCentral

Yamada K, Mizuno M, Nabeshima T (2002) Role for brain-derived neurotrophic factor in learning and memory. Life Sci 70(7):735–744. https://doi.org/10.1016/S0024-3205(01)01461-8 CrossRefPubMed

Yilmaz S, Ozan S, Benzer F, Canatan H (2003 Dec) Oxidative damage and antioxidant enzyme activities in experimental hypothyroidism. Cell Biochem Funct 21(4):325–330. https://doi.org/10.1002/cbf.1031 CrossRefPubMed

Young E, Cesena T, Meiri KF, Perrone-Bizzozero NI (2002) Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm. Hippocampus 12(4):457–464. https://doi.org/10.1002/hipo.10015 CrossRefPubMed

Zarifkar A, Choopani S, Ghasemi R, Naghdi N, Maghsoudi AH, Maghsoudi N, Rastegar K, Moosavi M (2010) Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis. Eur J Pharmacol 634(1–3):84–88. https://doi.org/10.1016/j.ejphar.2010.02.029 CrossRefPubMed

Zhang L, Blomgren K, Kuhn HG, Cooper-Kuhn CM (2009) Effects of postnatal thyroid hormone deficiency on neurogenesis in the juvenile and adult rat. Neurobiol Dis 34(2):366–374. https://doi.org/10.1016/j.nbd.2009.02.006 CrossRefPubMed

Zoeller TR, Dowling AL, Herzig CT, Iannacone EA, Gauger KJ, Bansal R (2002) Thyroid hormone, brain development, and the environment. Environ Health Perspect 110(Suppl 3):355–361. https://doi.org/10.1289/ehp.02110s3355 CrossRefPubMedPubMedCentral

Title: The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats
Authors: Yousef Baghcheghi
Farimah Beheshti
Mohammad Naser Shafei
Hossein Salmani
Hamid Reza Sadeghnia
Mohammad Soukhtanloo
Akbar Anaeigoudari
Mahmoud Hosseini
Publication date: 01-06-2018
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2018
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0176-0

ACC 2024 Congress

Springer Medicine

The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2018

Multimodal MR imaging in hepatic encephalopathy: state of the art

Serum ischemia modified albumin is a possible new marker of oxidative stress in phenylketonuria

Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors in rats following transient bilateral common carotid occlusion and reperfusion

Cardiovascular profile improvement during Natalizumab treatment

Clinical characteristics and mutation analysis of five Chinese patients with maple syrup urine disease

The role of tryptophan metabolism in postpartum depression