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01-02-2018 | Short Communication

Aversive and non-aversive memory impairment in the mucopolysaccharidosis II mouse model

Authors: Amanda Stapenhorst Azambuja, Lilian Correa, Bernardo Pappi Gabiatti, Giselle Renata Martins, Álvaro de Oliveira Franco, Maria Flávia Marques Ribeiro, Guilherme Baldo

Published in: Metabolic Brain Disease | Issue 1/2018

Abstract

Hunter syndrome (MPS II, OMIM 309900) is a lysosomal storage disorder due to deficient iduronate sulphatase activity. Patients present multiple cognitive alterations, and the aim of this work was to verify if MPS II mice also present some progressive cognitive alterations. For that, MPS II mice from 2 to 6 months of age were submitted to repeated open field and inhibitory avoidance tests to evaluate memory parameters. MPS II mice presented impaired memory at 6 months evaluated by open field test. They also performed poorly in the inhibitory avoidance test from 4 months. We conclude that MPS II mice develop cognitive alterations as the disease progresses. These tests can be used in the future to study the efficacy of therapeutic approaches in the central nervous system.

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Title: Aversive and non-aversive memory impairment in the mucopolysaccharidosis II mouse model
Authors: Amanda Stapenhorst Azambuja
Lilian Correa
Bernardo Pappi Gabiatti
Giselle Renata Martins
Álvaro de Oliveira Franco
Maria Flávia Marques Ribeiro
Guilherme Baldo
Publication date: 01-02-2018
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 1/2018
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0110-5

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Springer Medicine

Aversive and non-aversive memory impairment in the mucopolysaccharidosis II mouse model

Abstract

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Springer Medicine

Abstract

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