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01-10-2017 | Original Article

LY294002, a PI3K inhibitor, attenuates Tourette syndrome in rats

Authors: Long Hongyan, Wang Chunyan, Yang Yue’e

Published in: Metabolic Brain Disease | Issue 5/2017

Abstract

The present study was designed to investigate the effects of LY294002 on Tourette syndrome (TS) in rats. TS model was induced in rats by DOI (the selective 5-HT2A/2C agonist 1- (2, 5- dimethoxy −4 - iodophenyl) -2- aminopropane). Behavior was assessed by stereotypic score and autonomic activity. Inflammatory cytokines such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in serum and striatum were detected. The protein levels of PI3K/Akt/NF-B in striatum were detected by Western Blot. LY294002 treatment significantly reduced IL-6, IL-1β and TNF-α in serum and striatum of TS rats, Also, highly expressed P-PI3K, P-Akt, P-NF-κBp65, P-IκBα in TS rats were restored respectively by LY294002 treatment as indicted in western blot analysis and immunohistochemistry analysis. Thus, it was supposed that the protective effect of LY294002 against TS in rat might be associated with the regulation of PI3K/Akt/NF-B pathway.

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Title: LY294002, a PI3K inhibitor, attenuates Tourette syndrome in rats
Authors: Long Hongyan
Wang Chunyan
Yang Yue’e
Publication date: 01-10-2017
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 5/2017
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0051-z

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LY294002, a PI3K inhibitor, attenuates Tourette syndrome in rats

Abstract

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Abstract

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