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Metabolic Brain Disease
Published in: Metabolic Brain Disease 4/2017

01-08-2017 | Original Article

Brain heparan sulphate proteoglycans are altered in developing foetus when exposed to in-utero hyperglycaemia

Authors: M. S. Sandeep, C. D. Nandini

Published in: Metabolic Brain Disease | Issue 4/2017

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Abstract

In-utero exposure of foetus to hyperglycaemic condition affects the growth and development of the organism. The brain is one of the first organs that start to develop during embryonic period and glycosaminoglycans (GAGs) and proteoglycans (PGs) are one of the key molecules involved in its development. But studies on the effect of hyperglycaemic conditions on brain GAGs/PGs are few and far between. We, therefore, looked into the changes in brain GAGs and PGs at various developmental stages of pre- and post-natal rats from non-diabetic and diabetic mothers as well as in adult rats induced with diabetes using a diabetogenic agent, Streptozotocin. Increased expression of GAGs especially that of heparan sulphate class in various developmental stages were observed in the brain as a result of in-utero hyperglycaemic condition but not in that of adult rats. Changes in disaccharides of heparan sulphate (HS) were observed in various developmental stages. Furthermore, various HSPGs namely, syndecans-1 and -3 and glypican-1 were overexpressed in offspring from diabetic mother. However, in adult diabetic rats, only glypican-1 was overexpressed. The offsprings from diabetic mothers became hyperphagic at the end of 8 weeks after birth which can have implications in the long run. Our results highlight the likely impact of the in-utero exposure of foetus to hyperglycaemic condition on brain GAGs/PGs compared to diabetic adult rats.
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Metadata
Title
Brain heparan sulphate proteoglycans are altered in developing foetus when exposed to in-utero hyperglycaemia
Authors
M. S. Sandeep
C. D. Nandini
Publication date
01-08-2017
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 4/2017
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-017-0019-z

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