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Published in: Metabolic Brain Disease 2/2017

01-04-2017 | Short Communication

Current state of knowledge of hepatic encephalopathy (part IV): Management of Hepatic Encephalopathy by liver support systems

Author: Tarek Hassanein

Published in: Metabolic Brain Disease | Issue 2/2017

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Abstract

Hepatic Encephalopathy is a devastating complication of End-Stage Liver Disease. In its severe grades it requires extra intervention beyond the standard medical approaches. In this article were view the role of liver support systems in managing hepatic encephalopthy.
Literature
go back to reference Agrawal A, Sharma BC, Sharma P, Sarin SK (2012) Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy. Am J Gastroenterol 107(7):1043–1050CrossRefPubMed Agrawal A, Sharma BC, Sharma P, Sarin SK (2012) Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy. Am J Gastroenterol 107(7):1043–1050CrossRefPubMed
go back to reference Amodio P, Bemeur C, Butterworth R, et al. (2013) The nutritional management of hepatic encephalopathy in patients with cirrhosis: international society for hepatic encephalopathy and nitrogen metabolism consensus. Hepatology 58(1):325–336CrossRefPubMed Amodio P, Bemeur C, Butterworth R, et al. (2013) The nutritional management of hepatic encephalopathy in patients with cirrhosis: international society for hepatic encephalopathy and nitrogen metabolism consensus. Hepatology 58(1):325–336CrossRefPubMed
go back to reference Bajaj JS, Cordoba J, Mullen KD, et al. (2011) Review article: the design of clinical trials in hepatic encephalopathy: an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement. Aliment Pharmacol Ther 33(7):739–747CrossRefPubMedPubMedCentral Bajaj JS, Cordoba J, Mullen KD, et al. (2011) Review article: the design of clinical trials in hepatic encephalopathy: an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement. Aliment Pharmacol Ther 33(7):739–747CrossRefPubMedPubMedCentral
go back to reference Bañares R, Catalina M (2011) “Extracorporeal artificial liver support systems”. Clinical gastroenterology: Chronic Liver Failure. Ed. P Gines. Springer Science + Business Media, LLC. 501–519. Print Bañares R, Catalina M (2011) “Extracorporeal artificial liver support systems”. Clinical gastroenterology: Chronic Liver Failure. Ed. P Gines. Springer Science + Business Media, LLC. 501–519. Print
go back to reference Banares R, Nevens F, Larsen FS, et al. (2013) Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the relief trial. Hepatology 57(3):1153–1162CrossRefPubMed Banares R, Nevens F, Larsen FS, et al. (2013) Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the relief trial. Hepatology 57(3):1153–1162CrossRefPubMed
go back to reference Buckner CD, Clift RA, Volwiler W, Donohue DM, Burnell JM, Saunders FC, Thomas ED (1973) Plasma exchange in patients with fulminant hepatic failure. Arch Intern Med 132:487–492 Buckner CD, Clift RA, Volwiler W, Donohue DM, Burnell JM, Saunders FC, Thomas ED (1973) Plasma exchange in patients with fulminant hepatic failure. Arch Intern Med 132:487–492
go back to reference Cree IC, Straus E, Berger S, Voges P, Scotti P, Atkins P (1973) Plasma exchange in treatment of profound hepatic coma. N Y State J Med 73:569–576 Cree IC, Straus E, Berger S, Voges P, Scotti P, Atkins P (1973) Plasma exchange in treatment of profound hepatic coma. N Y State J Med 73:569–576
go back to reference Demeulenaere L, Barbier F, Vermeire P (1969) Plasmapheresis in hepatic coma. Lancet 1:152–153 Demeulenaere L, Barbier F, Vermeire P (1969) Plasmapheresis in hepatic coma. Lancet 1:152–153
go back to reference Dethloff T, Tofteng F, Frederiksen HJ, et al. (2008) Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study. World J Gastroenterol 14(13):2065–2071CrossRefPubMedPubMedCentral Dethloff T, Tofteng F, Frederiksen HJ, et al. (2008) Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study. World J Gastroenterol 14(13):2065–2071CrossRefPubMedPubMedCentral
go back to reference Evenepoel P, Laleman W, Wilmer A, et al. (2006) Prometheus versus molecular adsorbents recirculating system: comparison of efficacy in two different liver detoxification devices. Artif Organs 30(4):276–284CrossRefPubMed Evenepoel P, Laleman W, Wilmer A, et al. (2006) Prometheus versus molecular adsorbents recirculating system: comparison of efficacy in two different liver detoxification devices. Artif Organs 30(4):276–284CrossRefPubMed
go back to reference Ferenci P, Lockwood A, Mullen K, et al. (2002) Hepatic encephalopathy: definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th world congresses of gastroenterology, Vienna, 1998. Hepatology 35:716–721CrossRefPubMed Ferenci P, Lockwood A, Mullen K, et al. (2002) Hepatic encephalopathy: definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th world congresses of gastroenterology, Vienna, 1998. Hepatology 35:716–721CrossRefPubMed
go back to reference Freeman JG, Matthewson K, Record CO (1986) Plasmapheresis in acute liver failure. Int J Artif Organs 9:433–438 Freeman JG, Matthewson K, Record CO (1986) Plasmapheresis in acute liver failure. Int J Artif Organs 9:433–438
go back to reference Hassanein TI, Tofteng F, Brown RS Jr, et al. (2007) Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis. Hepatology 46(6):1853–1862CrossRefPubMed Hassanein TI, Tofteng F, Brown RS Jr, et al. (2007) Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis. Hepatology 46(6):1853–1862CrossRefPubMed
go back to reference Hassanein TI, Schade RR, Hepburn IS (2011) Acute-on-chronic liver failure: extracorporeal liver assist devices. Curr Opin Crit Care 17:195–203 Hassanein TI, Schade RR, Hepburn IS (2011) Acute-on-chronic liver failure: extracorporeal liver assist devices. Curr Opin Crit Care 17:195–203
go back to reference Kondrup J, Almdal T, Vilstrup H, Tygstrup N (1992) High volume plasma exchange in fulminant hepatic failure. Int J Artif Organs 15:669–676 Kondrup J, Almdal T, Vilstrup H, Tygstrup N (1992) High volume plasma exchange in fulminant hepatic failure. Int J Artif Organs 15:669–676
go back to reference Kribben A, Gerken G, Haag S, Herget-Rosenthal S, et al. (2012) Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure. Gastroenterology 142(4):782–789 e.3CrossRefPubMed Kribben A, Gerken G, Haag S, Herget-Rosenthal S, et al. (2012) Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure. Gastroenterology 142(4):782–789 e.3CrossRefPubMed
go back to reference Larsen FS, Hansen BA, Ejlersen E, Secher NH, Clemmesen JO, Tygstrup N, Knudsen GM (1996) Cerebral blood flow, oxygen metabolism and transcranial Doppler sonography during highvolume plasmapheresis in fulminant hepatic failure. Eur J Gastroenterol Hepatol 8:261–265 Larsen FS, Hansen BA, Ejlersen E, Secher NH, Clemmesen JO, Tygstrup N, Knudsen GM (1996) Cerebral blood flow, oxygen metabolism and transcranial Doppler sonography during highvolume plasmapheresis in fulminant hepatic failure. Eur J Gastroenterol Hepatol 8:261–265
go back to reference Laleman W, Wilmer A, Evenepoel P, et al. (2006) Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure. Crit Care 10(4):R108CrossRefPubMedPubMedCentral Laleman W, Wilmer A, Evenepoel P, et al. (2006) Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure. Crit Care 10(4):R108CrossRefPubMedPubMedCentral
go back to reference Lepore MJ, Stutman LJ, Bonanno CA, Conklin EF, Robilotti JG,McKenna PJ (1972) Plasmapheresis with plasma exchange in hepatic coma. II. Fulminant viral hepatitis as a systemic disease. Arch Intern Med 129:900–907 Lepore MJ, Stutman LJ, Bonanno CA, Conklin EF, Robilotti JG,McKenna PJ (1972) Plasmapheresis with plasma exchange in hepatic coma. II. Fulminant viral hepatitis as a systemic disease. Arch Intern Med 129:900–907
go back to reference Merli M, Lucidi C, Pentassuglio I, et al. (2013) Increased risk of cognitive impairment in cirrhotic patients with bacterial infections. J Hepatol 59(2):243–250CrossRefPubMed Merli M, Lucidi C, Pentassuglio I, et al. (2013) Increased risk of cognitive impairment in cirrhotic patients with bacterial infections. J Hepatol 59(2):243–250CrossRefPubMed
go back to reference Ortiz M, Jacas C, Cordoba J (2005) Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 42(suppl 1):S45–S53CrossRefPubMed Ortiz M, Jacas C, Cordoba J (2005) Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 42(suppl 1):S45–S53CrossRefPubMed
go back to reference Pugliese F, Novelli G, Poli L, et al. (2008) Hemodynamic improvement as an additional parameter to evaluate the safety and tolerability of the molecular adsorbent recirculating system in liver failure patients. Transplant Proc 40(6):1925–1928CrossRefPubMed Pugliese F, Novelli G, Poli L, et al. (2008) Hemodynamic improvement as an additional parameter to evaluate the safety and tolerability of the molecular adsorbent recirculating system in liver failure patients. Transplant Proc 40(6):1925–1928CrossRefPubMed
go back to reference Rahimi RS, Elliott AC, Rockey DC (2013) Altered mental status in cirrhosis: etiologies and outcomes. J Investig Med 61(4):695–700CrossRefPubMed Rahimi RS, Elliott AC, Rockey DC (2013) Altered mental status in cirrhosis: etiologies and outcomes. J Investig Med 61(4):695–700CrossRefPubMed
go back to reference Sekido H, Matsuo K, Takeda K, Ueda M, Morioka D, Kubota T, Tanaka K, Endo I, Togo S, Shimada H (2004) Usefulness of artificial liver support for pretransplant patients with fulminant hepatic failure. Transplant Proc 36:2355–2356 Sekido H, Matsuo K, Takeda K, Ueda M, Morioka D, Kubota T, Tanaka K, Endo I, Togo S, Shimada H (2004) Usefulness of artificial liver support for pretransplant patients with fulminant hepatic failure. Transplant Proc 36:2355–2356
go back to reference Splendiani G, Tancredi M, Daniele M, Giammaria U (1990) Treatment of acute liver failure with hemodetoxification techniques. Int J Artif Organs 13:370–374 Splendiani G, Tancredi M, Daniele M, Giammaria U (1990) Treatment of acute liver failure with hemodetoxification techniques. Int J Artif Organs 13:370–374
go back to reference Stenbog P, Busk T, Larsen FS (2013) Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange. Metab Brain Dis 28(2):333–335CrossRefPubMed Stenbog P, Busk T, Larsen FS (2013) Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange. Metab Brain Dis 28(2):333–335CrossRefPubMed
go back to reference Stepanova M, Mishra A, Venkatesan C, Younossi ZM (2012) In-hospital mortality and economic burden associated with hepatic encephalopathy in the United States from 2005 to 2009. Clin Gastroenterol Hepatol 10(9):1034–1041 e1CrossRefPubMed Stepanova M, Mishra A, Venkatesan C, Younossi ZM (2012) In-hospital mortality and economic burden associated with hepatic encephalopathy in the United States from 2005 to 2009. Clin Gastroenterol Hepatol 10(9):1034–1041 e1CrossRefPubMed
go back to reference Stewart CA, Malinchoc M, Kim WR, Kamath PS (2007) Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease. Liver Transpl 13(20):1366–1371CrossRefPubMed Stewart CA, Malinchoc M, Kim WR, Kamath PS (2007) Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease. Liver Transpl 13(20):1366–1371CrossRefPubMed
go back to reference Yoshiba M, Sekiyama K, Iwamura Y, Sugata F (1993) Development of reliable artificial liver support (ALS)–plasma exchange in combination with hemodiafiltration using high-performance membranes. Dig Dis Sci 38:469–476 Yoshiba M, Sekiyama K, Iwamura Y, Sugata F (1993) Development of reliable artificial liver support (ALS)–plasma exchange in combination with hemodiafiltration using high-performance membranes. Dig Dis Sci 38:469–476
Metadata
Title
Current state of knowledge of hepatic encephalopathy (part IV): Management of Hepatic Encephalopathy by liver support systems
Author
Tarek Hassanein
Publication date
01-04-2017
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 2/2017
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-016-9911-1

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