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01-06-2015 | Research Article

Induction of DJ-1 protects neuronal cells from isoflurane induced neurotoxicity

Authors: Wenjie Liu, Qulian Guo, Xiaoling Hu, Liangyu Peng, Bin Zhou

Published in: Metabolic Brain Disease | Issue 3/2015

Abstract

Oxidative stress, mitochondrial dysfunction and neuronal apoptosis are thought to be major contributors of Isoflurane toxicity. However, the underlying mechanisms remain largely to be determined. DJ-1, a protein that is involved in the response to various kinds of stress, has shown its neuroprotective effects. Whether DJ-1 has a neuroprotective effect against isoflurane-induced neurotoxocity is still unknown. In this study, we found that expression of DJ-1 is elevated in response to isoflurane treatment in human SH-SY5Y neuroblastoma cells. In order to clarify whether DJ-1 plays a potential role in isoflurane neurotoxicity or as a compensatory response for survival, we investigated the effects of DJ-1 silencing in isoflurane neurotoxicity. Our findings indicate that knockdown of DJ-1 promotes isoflurane-induced oxidative stress and mitochondrial dysfunction. Importantly, DJ-1 silencing was found to exacerbate isoflurane- induced apoptosis through modulation of mitochondria-dependent apoptosis pathways, thereby suggesting that induction of DJ-1 in response to isoflurane might act as a compensatory response for cell survival.

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Title: Induction of DJ-1 protects neuronal cells from isoflurane induced neurotoxicity
Authors: Wenjie Liu
Qulian Guo
Xiaoling Hu
Liangyu Peng
Bin Zhou
Publication date: 01-06-2015
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2015
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9622-4

At a glance: The STEP trials

Springer Medicine

Induction of DJ-1 protects neuronal cells from isoflurane induced neurotoxicity

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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