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01-02-2015 | Review Article

“Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis”

Authors: Upendra Yadav, Pradeep Kumar, Sushil Kumar Yadav, Om Prakash Mishra, Vandana Rai

Published in: Metabolic Brain Disease | Issue 1/2015

Abstract

Epidemiological studies have evaluated the association between maternal methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms and risk of neural tube defects (NTDs) in offspring. However, the results from the published studies on the association between these three polymorphisms and NTD risk are conflicting. To derive a clearer picture of association between these three maternal polymorphisms and risk of NTD, we performed meta-analysis. A comprehensive search was conducted to identify all case–control studies of maternal MTHFR and MTRR polymorphisms and NTD risk. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the strength of the association. Overall, we found that maternal MTHFR C677T polymorphism (OR_TvsC =1.20; 95 % CI = 1.13–1.28) and MTRR A66G polymorphism (OR_GvsA = 1.21; 95 % CI = 0.98–1.49) were risk factors for producing offspring with NTD but maternal MTHFR A1298C polymorphism (OR_CvsA = 0.91; 95 % CI = 0.78–1.07) was not associated with NTD risk. However, in stratified analysis by geographical regions, we found that the maternal C677T polymorphism was significantly associated with the risk of NTD in Asian (OR_TvsC = 1.43; 95 % CI: 1.05–1.94), European (OR_TvsC = 1.13; 95 % CI: 1.04–1.24) and American (OR_TvsC = 1.26; 95 % CI: 1.13–1.41) populations. In conclusion, present meta-analysis supports that the maternal MTHFR C677T and MTRR A66G are polymorphisms contributory to risk for NTD.

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Title: “Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis”
Authors: Upendra Yadav
Pradeep Kumar
Sushil Kumar Yadav
Om Prakash Mishra
Vandana Rai
Publication date: 01-02-2015
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 1/2015
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9575-7

At a glance: The STEP trials

Springer Medicine

“Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis”

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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