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01-04-2015 | Research Article

Recent advances in the pharmacologic treatment of spinal cord injury

Authors: April Cox, Abhay Varma, Naren Banik

Published in: Metabolic Brain Disease | Issue 2/2015

Abstract

A need exists for the effective treatment of individuals suffering from spinal cord injury (SCI). Recent advances in the understanding of the pathophysiological mechanisms occurring in SCI have resulted in an expansion of new therapeutic targets. This review summarizes both preclinical and clinical findings investigating the mechanisms and cognate pharmacologic therapeutics targeted to modulate hypoxia, ischemia, excitotoxicity, inflammation, apoptosis, epigenetic alterations, myelin regeneration and scar remodeling. Successful modulation of these targets has been demonstrated in both preclinical and clinical studies with agents such as Oxycyte, Minocycline, Riluzole, Premarin, Cethrin, and ATI-355. The translation of these agents into clinical studies highlights the progress the field has made in the past decade. SCI proves to be a complex condition; the numerous pathophysiological mechanisms occurring at varying time points suggests that a single agent approach to the treatment of SCI may not be optimal. As the field continues to mature, the hope is that the knowledge gained from these studies will be applied to the development of an effective multi-pronged treatment strategy for SCI.

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Title: Recent advances in the pharmacologic treatment of spinal cord injury
Authors: April Cox
Abhay Varma
Naren Banik
Publication date: 01-04-2015
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 2/2015
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9547-y

At a glance: The STEP trials

Springer Medicine

Recent advances in the pharmacologic treatment of spinal cord injury

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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