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01-06-2013 | Original Paper

In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using ¹H Magnetic Resonance Spectroscopy

Author: Cristina Cudalbu

Published in: Metabolic Brain Disease | Issue 2/2013

Abstract

Hepatic encephalopathy (HE) is a common and severe neuropsychiatric complication present in acute and chronic liver disease. The unique advantages of high field ¹H MRS provide a method for assessing pathogenic mechanism, diagnosis and monitoring of HE, as well as for treatment assessment or recovery after liver transplantation, in a reproducible and reliable non-invasive way. The purpose of the present review is to present some new features of in vivo proton Magnetic Resonance Spectroscopy (¹H MRS) at high magnetic fields combined with some basic requirements for reliable metabolic profiling. Finally, in vivo applications of ¹H MRS in different HE animal models are presented.

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Title: In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using 1H Magnetic Resonance Spectroscopy
Author: Cristina Cudalbu
Publication date: 01-06-2013
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 2/2013
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-012-9368-9

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In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using ¹H Magnetic Resonance Spectroscopy

Abstract

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