Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Maternal and Child Health Journal
Published in: Maternal and Child Health Journal 6/2017

01-06-2017

Markers of Oxidative Stress in Human Milk do not Differ by Maternal BMI But are Related to Infant Growth Trajectories

Authors: Bridget E. Young, Zachary W. Patinkin, Laura Pyle, Becky de la Houssaye, Barbara S. Davidson, Sheela Geraghty, Ardythe L. Morrow, Nancy Krebs

Published in: Maternal and Child Health Journal | Issue 6/2017

Login to get access

Abstract

Objective Obesity in adults is associated with inflammation and oxidative stress. Whether or not this phenotype is reflected in human milk (HM) composition, or may impact infant growth remains unknown. We investigated whether HM from overweight/obese (OW/Ob) mothers exhibited higher concentrations of inflammatory cytokines and markers of oxidative stress. We also correlated these bioactive components with infant growth patterns. Methods This was an observational cohort of 56 breastfeeding mothers and their infants [33 normal weight (NW) and 23 OW/Ob]. Infants were followed until 6 months of age and HM collected at 2-weeks and 4-months. Results Markers of oxidative stress, 8-hydroxy-deoxyguanosine (8OHdG) and 4-hydroxynonenol (HNE), decreased in HM over time (p < 0.001) and did not differ between NW and OW/Ob women. Concentrations of inflammatory cytokines, IL-6, IL-8, and TNF-α, were all inter-correlated (p < 0.001) but did not differ between NW and OW/Ob women. HM fat, protein, lactose, and total calories did not differ between NW and OW/Ob women. Infant growth patterns did not differ by group. In a model of infant weight-for-length-Z score trajectory, there was a significant interaction between both lactose and 8OHdG with maternal group: HM lactose and 8OHdG concentrations were both positively associated with increases in WLZ trajectory only among infants breastfed by OW/Ob mothers. Conclusions for Practice HM composition was relatively stable between NW and OW/Ob women. In exclusively breastfed infants, HM concentrations of lactose and 8OHdG, a marker of oxidative stress, may contribute to regulation of infant weight gain, especially among infants of OW/Ob women.
Literature
Ahuja, S., Boylan, M., Hart, S., Roman-Shriver, C., Spallholz, J., Pence, B., & Sawyer, B. (2011). Glucose and insulin levels are increased in obese and overweight mothers’ breast-milk. Food and Nutrition Sciences, 2, 201–206.CrossRef
Alexandre, V., Even, P. C., Larue-Achagiotis, C., Blouin, J. M., Blachier, F., Benamouzig, R., … & Davila, A. M. (2013). Lactose malabsorption and colonic fermentations alter host metabolism in rats. British Journal of Nutrition, 110(4), 625–631. doi:10.​1017/​S000711451200555​7.CrossRefPubMed
Barbosa, L., Butte, N. F., Villalpando, S., Wong, W. W., & Smith, E. O. (1997). Maternal energy balance and lactation performance of Mesoamerindians as a function of body mass index. The American Journal of Clinical Nutrition, 66(3), 575–583.PubMed
Beyerlein, A., & von Kries, R. (2011). Breastfeeding and body composition in children: Will there ever be conclusive empirical evidence for a protective effect against overweight? American Journal of Clinical Nutrition, 94(6 Suppl), 1772S–1775S. doi:10.​3945/​ajcn.​110.​000547.CrossRefPubMed
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005). Metabolic syndrome in childhood: Association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics, 115(3), e290–e296. doi:10.​1542/​peds.​2004-1808.CrossRefPubMed
Buyken, A. E., Karaolis-Danckert, N., Remer, T., Bolzenius, K., Landsberg, B., & Kroke, A. (2008). Effects of breastfeeding on trajectories of body fat and BMI throughout childhood., 16(2), 389–395. doi:10.​1038/​oby.​2007.​57.
Crume, T. L., Ogden, L. G., Mayer-Davis, E. J., Hamman, R. F., Norris, J. M., Bischoff, K. J., … Dabelea, D. (2012). The impact of neonatal breast-feeding on growth trajectories of youth exposed and unexposed to diabetes in utero: The EPOCH Study. International Journal of Obesity, 36(4), 529–534.CrossRefPubMedPubMedCentral
Druet, C., Stettler, N., Sharp, S., Simmons, R. K., Cooper, C., Smith, G. D., … & Ong, K. K. (2012). Prediction of childhood obesity by infancy weight gain: An individual-level meta-analysis. Paediatric Perinatal Epidemiology, 26(1), 19–26.CrossRefPubMed
Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A., & Wan, Y. (2012). Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes and Development, 26(12), 1306–1311.CrossRefPubMedPubMedCentral
Geraghty, S. R., Davidson, B. S., Warner, B. B., Sapsford, A. L., Ballard, J. L., List, B. A., … & Morrow, A. L. (2005). The development of a research human milk bank. Journal of Human Lactation, 21(1), 59–66.CrossRefPubMed
Gorski, J. N., Dunn-Meynell, A. A., Hartman, T. G., & Levin, B. E. (2006). Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 291(3), R768–R778. doi:10.​1152/​ajpregu.​00138.​2006.PubMed
Groer, M. W., & Shelton, M. M. (2009). Exercise is associated with elevated proinflammatory cytokines in human milk. J.Obstet.Gynecol.Neonatal Nurs., 38(1), 35–41.CrossRefPubMed
He, T., Priebe, M. G., Harmsen, H. J., Stellaard, F., Sun, X., Welling, G. W., & Vonk, R. J. (2006). Colonic fermentation may play a role in lactose intolerance in humans. Journal of Nutrition, 136(1), 58–63.PubMed
Huh, J. Y., Son, D. J., Lee, Y., Lee, J., Kim, B., Lee, H. M., … & Chung, M. H. (2012). 8-Hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation. Free Radical Biology and Medicine, 53(1), 109–121. doi:10.​1016/​j.​freeradbiomed.​2012.​03.​023.CrossRefPubMed
Kalliomaki, M., Collado, M. C., Salminen, S., & Isolauri, E. (2008). Early differences in fecal microbiota composition in children may predict overweight. The American Journal of Clinical Nutrition, 87(3), 534–538.PubMed
Kim, D. H., Cho, I. H., Kim, H. S., Jung, J. E., Kim, J. E., Lee, K. H., … & Chung, M. H. (2006a). Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: Suppression of STAT3-mediated intercellular adhesion molecule-1 expression. Experimental and Molecular Medicine, 38(4), 417–427. doi:10.​1038/​emm.​2006.​49.
Kim, H. S., Ye, S. K., Cho, I. H., Jung, J. E., Kim, D. H., Choi, S., … & Chung, M. H. (2006b). 8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia. Free Radical Biology and Medicine, 41(9), 1392–1403. doi:10.​1016/​j.​freeradbiomed.​2006.​07.​018.
Kirchner, S., Kieu, T., Chow, C., Casey, S., & Blumberg, B. (2010). Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes. Molecular endocrinology (Baltimore, Md.), 24(3), 526–539.CrossRef
Lam, P. M., Mistry, V., Marczylo, T. H., Konje, J. C., Evans, M. D., & Cooke, M. S. (2012). Rapid measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography-tandem mass spectrometry. Free Radical Biology and Medicine, 52(10), 2057–2063.CrossRefPubMedPubMedCentral
Lawrence, R. A., Lawrence, R. M. (2011). Breastfeeding—a guide for the medical professional (7th ed.). Philadelphia: Elsevier Mosby.
Lee, S. H., Taek Han, S., Choi, S. W., Sung, S. Y., You, H. J., Ye, S. K., & Chung, M. H. (2009). Inhibition of Rac and Rac-linked functions by 8-oxo-2′-deoxyguanosine in murine macrophages. Free Radical Research, 43(1), 78–84. doi:10.​1080/​1071576080260943​2.CrossRefPubMed
Li, C., Kaur, H., Choi, W. S., Huang, T. T., Lee, R. E., & Ahluwalia, J. S. (2005). Additive interactions of maternal prepregnancy BMI and breast-feeding on childhood overweight. Obesity Research, 13(2), 362–371. doi:10.​1038/​oby.​2005.​48.CrossRefPubMed
Martin, L. J., Woo, J. G., Geraghty, S. R., Altaye, M., Davidson, B. S., Banach, W., … & Morrow, A. L. (2006). Adiponectin is present in human milk and is associated with maternal factors. The American Journal of Clinical Nutrition, 83(5), 1106–1111.PubMed
Mayer-Davis, E. J., Rifas-Shiman, S. L., Zhou, L., Hu, F. B., Colditz, G. A., & Gillman, M. W. (2006). Breast-feeding and risk for childhood obesity: Does maternal diabetes or obesity status matter? Diabetes Care, 29(10), 2231–2237.CrossRefPubMedPubMedCentral
Michalski, M. C., Calzada, C., Makino, A., Michaud, S., & Guichardant, M. (2008). Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk—a preliminary study. Molecular Nutrition & Food Research, 52(12), 1478–1485.CrossRef
Monteiro, P. O., & Victora, C. G. (2005). Rapid growth in infancy and childhood and obesity in later life—a systematic review. Obesity Reviews, 6(2), 143–154.CrossRefPubMed
Oben, J. A., Mouralidarane, A., Samuelsson, A. M., Matthews, P. J., Morgan, M. L., McKee, C., … & Taylor, P. D. (2010). Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. Journal of Hepatology, 52(6), 913–920.CrossRefPubMed
Sederquist, B., Fernandez-Vojvodich, P., Zaman, F., & Savendahl, L. (2014). Recent research on the growth plate: Impact of inflammatory cytokines on longitudinal bone growth. Journal of Molecular Endocrinology, 53(1), T35–44. doi:10.​1530/​JME-14-0006.
Szlagatys-Sidorkiewicz, A., Zagierski, M., Jankowska, A., Luczak, G., Macur, K., Baczek, T., … Kaminska, B (2012). Longitudinal study of vitamins A, E and lipid oxidative damage in human milk throughout lactation. Early Human Development, 88(6), 421–424. doi:10.​1016/​j.​earlhumdev.​2011.​10.​007.CrossRefPubMed
Taveras, E. M., Rifas-Shiman, S. L., Sherry, B., Oken, E., Haines, J., Kleinman, K., … & Gillman, M. W. (2011). Crossing growth percentiles in infancy and risk of obesity in childhood. Archives of Pediatrics and Adolescent Medicine, 165(11), 993–998.CrossRefPubMed
Whitaker, R. C. (2004). Predicting preschooler obesity at birth: The role of maternal obesity in early pregnancy. Pediatrics, 114(1), e29–e36.CrossRefPubMed
Metadata
Title
Markers of Oxidative Stress in Human Milk do not Differ by Maternal BMI But are Related to Infant Growth Trajectories
Authors
Bridget E. Young
Zachary W. Patinkin
Laura Pyle
Becky de la Houssaye
Barbara S. Davidson
Sheela Geraghty
Ardythe L. Morrow
Nancy Krebs
Publication date
01-06-2017
Publisher
Springer US
Published in
Maternal and Child Health Journal / Issue 6/2017
Print ISSN: 1092-7875
Electronic ISSN: 1573-6628
DOI
https://doi.org/10.1007/s10995-016-2243-2

Other articles of this Issue 6/2017

Maternal and Child Health Journal 6/2017 Go to the issue

From the Field

Critical Congenital Heart Disease Newborn Screening Implementation: Lessons Learned

OriginalPaper

An Analysis of Determinants of Under-5 Mortality across Countries: Defining Priorities to Achieve Targets in Sustainable Developmental Goals

OriginalPaper

Does Pregnancy Increase Use and Awareness of Nutrition Information in Food Labels?

OriginalPaper

An Examination of Care Practices of Pregnant Women Incarcerated in Jail Facilities in the United States

OriginalPaper

Higher Pre-pregnancy BMI and Excessive Gestational Weight Gain are Risk Factors for Rapid Weight Gain in Infants

OriginalPaper

Maternal Nonstandard Work Schedules and Breastfeeding Behaviors