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Published in: Journal of Medical Systems 5/2011

01-10-2011 | Original Paper

Highly Sensitive Computer Aided Diagnosis System for Breast Tumor Based on Color Doppler Flow Images

Authors: Xian-Fen Diao, Xin-Yu Zhang, Tian-Fu Wang, Si-Ping Chen, Ying Yang, Ling Zhong

Published in: Journal of Medical Systems | Issue 5/2011

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Abstract

A computer-aided diagnosis (CAD) system for breast tumor based on color Doppler flow images is proposed. Our system consists of automatic segmentation, feature extraction, and classification of breast tumors. First, the B-mode grayscale image containing anatomical information was separated from a color Doppler flow image (CDFI). Second, the boundary of the breast tumor was automatically defined in the B-mode image and then morphologic and gray features were extracted. Third, an optimal feature vector was created using K-means cluster algorithm. Then a back-propagation (BP) artificial neural network (ANN) was used to classify breast tumors as benign, malignant or uncertain. Finally, the blood flow feature was extracted selectively from the CDFI, and was used to classify the uncertain tumor as benign or malignant. Experiments on 500 cases show that the proposed system yields an accuracy of 100% for the malignant and 80.8% for the benign classification. Comparing with other systems, the advantage of our system is that it has a much lower percentage of malignant tumor misdiagnosis.
Literature
1.
go back to reference Chen, D. R., Chang, R. F., and Huang, Y. L., Breast cancer diagnosis using self-organizing map for sonography. Ultrasound Med. Biol. 26(3):405–411, 2000.CrossRef Chen, D. R., Chang, R. F., and Huang, Y. L., Breast cancer diagnosis using self-organizing map for sonography. Ultrasound Med. Biol. 26(3):405–411, 2000.CrossRef
2.
go back to reference Wang, Y. Y., Shen, J. L., Guo, Y., et al, Computerized classification of breast tumors with morphologic and texture features of ultrasonic images. 21st IEEE International Symposium on CBMS 23–28, 2008. Wang, Y. Y., Shen, J. L., Guo, Y., et al, Computerized classification of breast tumors with morphologic and texture features of ultrasonic images. 21st IEEE International Symposium on CBMS 23–28, 2008.
3.
go back to reference Chen, D. R., Chang, R. F., and Huang, Y. L., Computer-aided diagnosis applied to US of solid breast nodules by using neural networks. Radiology 213:407–412, 1999. Chen, D. R., Chang, R. F., and Huang, Y. L., Computer-aided diagnosis applied to US of solid breast nodules by using neural networks. Radiology 213:407–412, 1999.
4.
go back to reference Drukker, K., Gruszauskas, N. P., Sennett, C. A., and Giger, M. L., Breast US computer-aided diagnosis workstation:performance with a large clinical diagnostic population. Radiology 248(2):392–397, 2008.CrossRef Drukker, K., Gruszauskas, N. P., Sennett, C. A., and Giger, M. L., Breast US computer-aided diagnosis workstation:performance with a large clinical diagnostic population. Radiology 248(2):392–397, 2008.CrossRef
5.
go back to reference Chou, Y. H., Tiu, C. M., Hung, G. S., et al., Stepwise logistic regression analysis of tumor contour features for breast ultrasound diagnosis. Ultrasound Med. Biol. 27(11):1493–1498, 2001.CrossRef Chou, Y. H., Tiu, C. M., Hung, G. S., et al., Stepwise logistic regression analysis of tumor contour features for breast ultrasound diagnosis. Ultrasound Med. Biol. 27(11):1493–1498, 2001.CrossRef
6.
go back to reference Chen, D. R., Chang, R. F., Kuo, W. J., et al., Diagnosis of breast tumors with sonographic texture analysis using wavelet transform and neural networks. Ultrasound Med. Biol. 28(10):1301–1310, 2002.CrossRef Chen, D. R., Chang, R. F., Kuo, W. J., et al., Diagnosis of breast tumors with sonographic texture analysis using wavelet transform and neural networks. Ultrasound Med. Biol. 28(10):1301–1310, 2002.CrossRef
7.
go back to reference Chang, R. F., Wu, W. J., Woo, K. M., et al., Improvement in breast tumor discrimination by support vector machines and speckle-emphasis texture analysis. Ultrasound Med. Biol. 29(5):679–686, 2003.CrossRef Chang, R. F., Wu, W. J., Woo, K. M., et al., Improvement in breast tumor discrimination by support vector machines and speckle-emphasis texture analysis. Ultrasound Med. Biol. 29(5):679–686, 2003.CrossRef
8.
go back to reference Zheng, Y., James, F. G., and John, J. G., Reduction of breast biopsies with a modified self-organizing map. Proc. SPIE 3033:384–391, 1997.CrossRef Zheng, Y., James, F. G., and John, J. G., Reduction of breast biopsies with a modified self-organizing map. Proc. SPIE 3033:384–391, 1997.CrossRef
9.
go back to reference McNicholas, M. M., Mercer, P. M., Miller, J. C., et al., Color Doppler sonography in the evaluation of palpable breast masses. Am J. Roentgenol. 161:765–771, 1993. McNicholas, M. M., Mercer, P. M., Miller, J. C., et al., Color Doppler sonography in the evaluation of palpable breast masses. Am J. Roentgenol. 161:765–771, 1993.
10.
go back to reference Adler, D. D., Carson, P. L., Rubin, J. L., et al., Doppler ultrasound color flow imaging in the study of breast cancer: Preliminary findings. Ultrasound Med. Biol. 16(6):553–559, 1990.CrossRef Adler, D. D., Carson, P. L., Rubin, J. L., et al., Doppler ultrasound color flow imaging in the study of breast cancer: Preliminary findings. Ultrasound Med. Biol. 16(6):553–559, 1990.CrossRef
11.
go back to reference Raza, S., and Baum, J. K., Solid breast lesions: evaluation with power Doppler US. Radiology 203(1):164–168, 1997. Raza, S., and Baum, J. K., Solid breast lesions: evaluation with power Doppler US. Radiology 203(1):164–168, 1997.
12.
go back to reference Zhao, S. K., Li, D. Y., Yin, L. X., et al., Ultrasound Doppler tissue image analysis based on neural network. Proc. SPIE 4555:87–92, 2001.CrossRef Zhao, S. K., Li, D. Y., Yin, L. X., et al., Ultrasound Doppler tissue image analysis based on neural network. Proc. SPIE 4555:87–92, 2001.CrossRef
13.
go back to reference Huang, Y. L., Jiang, Y. R., Chen, D. R., et al., Level set contouring for breast tumor in sonography. J. Digit. Imaging 20(3):238–247, 2007.CrossRef Huang, Y. L., Jiang, Y. R., Chen, D. R., et al., Level set contouring for breast tumor in sonography. J. Digit. Imaging 20(3):238–247, 2007.CrossRef
14.
go back to reference Ladak, H. M., Mao, F., Wang, Y., et al., Prostate boundary segmentation from 2D ultrasound images. Med. Phys. 27(8):1777–1788, 2000.CrossRef Ladak, H. M., Mao, F., Wang, Y., et al., Prostate boundary segmentation from 2D ultrasound images. Med. Phys. 27(8):1777–1788, 2000.CrossRef
15.
go back to reference Horsch, K., Giger, M. L., Venta, L. A., et al., Automatic segmentation of breast lesions on ultrasound. Med. Phys. 28(8):1652–1659, 2001.CrossRef Horsch, K., Giger, M. L., Venta, L. A., et al., Automatic segmentation of breast lesions on ultrasound. Med. Phys. 28(8):1652–1659, 2001.CrossRef
16.
go back to reference Overhoff, H. M., Cornelius, T., Maas, S., et al., Visualization of anatomical structures of epigastric organs by use of automatically segmented 3-D ultrasound image volumes-first results. Biomed. Tech. 47(Suppl 1 Pt 2):633–635, 2002.CrossRef Overhoff, H. M., Cornelius, T., Maas, S., et al., Visualization of anatomical structures of epigastric organs by use of automatically segmented 3-D ultrasound image volumes-first results. Biomed. Tech. 47(Suppl 1 Pt 2):633–635, 2002.CrossRef
17.
go back to reference Chen, D. R., Chang, R. F., Wu, W. J., et al., 3-D breast ultrasound segmentation using active contour model. Ultrasound Med Biol 29(7):1017–1026, 2003.CrossRef Chen, D. R., Chang, R. F., Wu, W. J., et al., 3-D breast ultrasound segmentation using active contour model. Ultrasound Med Biol 29(7):1017–1026, 2003.CrossRef
18.
go back to reference Zhao, N., Chen, Y. Q., Yu, J. G., et al., Study on snake model in the ultrasound image processing. Shanghai Journal of Biomedical Engineering 25(4):3–9, 2004. Zhao, N., Chen, Y. Q., Yu, J. G., et al., Study on snake model in the ultrasound image processing. Shanghai Journal of Biomedical Engineering 25(4):3–9, 2004.
19.
go back to reference Perona, P., and Malik, J., Scale-space and edge detection using anisotropic diffusion. IEEE Trans. Pattern Anal. Mach. Intell. 12(7):629–639, 1990.CrossRef Perona, P., and Malik, J., Scale-space and edge detection using anisotropic diffusion. IEEE Trans. Pattern Anal. Mach. Intell. 12(7):629–639, 1990.CrossRef
20.
go back to reference Peng Yun. Segmentation of medical ultrasound image based on active contour model. Master’s thesis, Sichuan University, 2006. Peng Yun. Segmentation of medical ultrasound image based on active contour model. Master’s thesis, Sichuan University, 2006.
21.
go back to reference Zhang, J., Ultrasound diagnosis of the breast disease. Chinese Journal of Ultrasound Diagnosis 12(1):53–54, 2001. Zhang, J., Ultrasound diagnosis of the breast disease. Chinese Journal of Ultrasound Diagnosis 12(1):53–54, 2001.
22.
go back to reference Zheng, R. Y., Lu, W. P., Yu, D. J., et al., Detecting false benign in breast cancer diagnosis. Proceedings of the IEEE-INNS-ENNS International Joint Conference on Neural Networks 3:655–658, 2000. Zheng, R. Y., Lu, W. P., Yu, D. J., et al., Detecting false benign in breast cancer diagnosis. Proceedings of the IEEE-INNS-ENNS International Joint Conference on Neural Networks 3:655–658, 2000.
23.
go back to reference Liu, X., Zhang, G. W., and Martin, D., Fractal description and classification of breast tumor. Annual International Conference of the IEEE Engineering in Medicine and Biology Society 13(1):112–113, 1991. Liu, X., Zhang, G. W., and Martin, D., Fractal description and classification of breast tumor. Annual International Conference of the IEEE Engineering in Medicine and Biology Society 13(1):112–113, 1991.
24.
go back to reference Guita, R., Angela, C. S., Gail, C. H., et al., Benign versus malignant solid breast masses: US differentiation. Radiology 213(3):889–894, 1999. Guita, R., Angela, C. S., Gail, C. H., et al., Benign versus malignant solid breast masses: US differentiation. Radiology 213(3):889–894, 1999.
25.
go back to reference Stanislaw, O., and Nghia, D. D., Fourier and wavelet descriptors for shape recognition using neural networks: A comparative study. Pattern Recogn. 35(9):1949–1957, 2002.CrossRef Stanislaw, O., and Nghia, D. D., Fourier and wavelet descriptors for shape recognition using neural networks: A comparative study. Pattern Recogn. 35(9):1949–1957, 2002.CrossRef
26.
go back to reference Miguel, A. F., Patricia, A. F., Luis, A. L., et al, Computer-aided measurement of solid breast tumor features on ultrasound Images, CVAMIA04, 117(3):353–364, 2004. Miguel, A. F., Patricia, A. F., Luis, A. L., et al, Computer-aided measurement of solid breast tumor features on ultrasound Images, CVAMIA04, 117(3):353–364, 2004.
27.
go back to reference Lefebvre, F., Meunier, M., Thibault, F., et al., Computerized ultrasound B-scan characterization of breast nodules. Ultrasound Med. Biol. 26(9):1421–1428, 2000.CrossRef Lefebvre, F., Meunier, M., Thibault, F., et al., Computerized ultrasound B-scan characterization of breast nodules. Ultrasound Med. Biol. 26(9):1421–1428, 2000.CrossRef
Metadata
Title
Highly Sensitive Computer Aided Diagnosis System for Breast Tumor Based on Color Doppler Flow Images
Authors
Xian-Fen Diao
Xin-Yu Zhang
Tian-Fu Wang
Si-Ping Chen
Ying Yang
Ling Zhong
Publication date
01-10-2011
Publisher
Springer US
Published in
Journal of Medical Systems / Issue 5/2011
Print ISSN: 0148-5598
Electronic ISSN: 1573-689X
DOI
https://doi.org/10.1007/s10916-010-9461-8

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