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Journal of Mammary Gland Biology and Neoplasia

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Open Access 01-12-2020

How to Use Online Tools to Generate New Hypotheses for Mammary Gland Biology Research: A Case Study for Wnt7b

Authors: Yorick Bernardus Cornelis van de Grift, Nika Heijmans, Renée van Amerongen

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 4/2020

Abstract

An increasing number of ‘-omics’ datasets, generated by labs all across the world, are becoming available. They contain a wealth of data that are largely unexplored. Not every scientist, however, will have access to the required resources and expertise to analyze such data from scratch. Fortunately, a growing number of investigators is dedicating their time and effort to the development of user friendly, online applications that allow researchers to use and investigate these datasets. Here, we will illustrate the usefulness of such an approach. Using regulation of Wnt7b expression as an example, we will highlight a selection of accessible tools and resources that are available to researchers in the area of mammary gland biology. We show how they can be used for in silico analyses of gene regulatory mechanisms, resulting in new hypotheses and providing leads for experimental follow up. We also call out to the mammary gland community to join forces in a coordinated effort to generate and share additional tissue-specific ‘-omics’ datasets and thereby expand the in silico toolbox.

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Title: How to Use Online Tools to Generate New Hypotheses for Mammary Gland Biology Research: A Case Study for Wnt7b
Authors: Yorick Bernardus Cornelis van de Grift
Nika Heijmans
Renée van Amerongen
Publication date: 01-12-2020
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 4/2020
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-020-09474-z

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