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Journal of Mammary Gland Biology and Neoplasia

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01-12-2019 | Testicular Carcinoma

Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate

Authors: Anastasia Frank-Kamenetskii, Brian W. Booth

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 4/2019

Abstract

Tissue microenvironments, also known as stem cell niches, influence not only resident cells but also cells in surrounding tissues. Physical and biochemical intercellular signals originating from resident stem cells or non-stem cells participate in the homeostasis of the tissue regulating cell proliferation, differentiation, wound healing, tissue remodeling, and tumorigenesis. In recent publications it has been demonstrated that the normal mouse mammary microenvironment can provide development and differentiation guidance to not only resident mammary cells but also cells of non-mammary origin including tumor-derived cells. When placed in reforming mammary stem cell niches the non-mammary cells proliferate and differentiate along mammary epithelial cell lineages and contribute progeny to reforming mammary gland outgrowths. The tumor-derived cells that are redirected to assume mammary epithelial phenotypes lose their cancer-forming capacity and shift their gene expression profiles from a cancer profile towards a normal mammary epithelial expression profile. This review summarizes the recent discoveries regarding the ability of the normal mouse mammary microenvironment to dictate the cell fates of non-mammary cells introduced into mammary stem cell niches.

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Title: Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate
Authors: Anastasia Frank-Kamenetskii
Brian W. Booth
Publication date: 01-12-2019
Publisher: Springer US
Keywords: Testicular Carcinoma
Testicular Carcinoma
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 4/2019
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-019-09439-x

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