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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-06-2013

Wnt-Signalling in the Embryonic Mammary Gland

Authors: Kata Boras-Granic, Paul A. Hamel

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2/2013

Abstract

The first member of the Wnt-family ligands was identified 30 years ago as a factor in mouse mammary tumours whose expression was deregulated due to the promoter activity emanating from the proximal integration of the Mouse Mammary Tumour Virus genome (Nusse and Varmus, Embo J 31:2670–84, 2012). The Wnt-ligands invoke a number of molecular-genetic signalling cascades fundamental to the patterning of developing tissues and organs during embryogenesis as well as during postnatal development. The Wnt-signalling cascade that controls the activities of β-catenin and the T-cell Factor (Tcf)/Lympoid enhancer factor (Lef1) plays a fundamental role in control of all stages of embryonic mammary gland development. We provide here a brief overview of the known aspects of Wnt-signalling activities in the embryonic mammary gland and its interactions with other signalling cascades in this developing tissue.

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Title: Wnt-Signalling in the Embryonic Mammary Gland
Authors: Kata Boras-Granic
Paul A. Hamel
Publication date: 01-06-2013
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 2/2013
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-013-9280-x

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