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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-03-2008

Jak2/Stat5 Signaling in Mammogenesis, Breast Cancer Initiation and Progression

Authors: Kay-Uwe Wagner, Hallgeir Rui

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 1/2008

Abstract

During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse models support a role for the Stat5 transcription factor as a proto-oncogene in mammary tumor initiation. On the other hand, the analysis of nuclear Stat5 in human breast malignancies suggests a role of the Jak2/Stat5 pathway in the restriction of the metastatic potential of neoplastic mammary epithelial cells. Following an overview on the function of the Jak2/Stat5 pathway during normal mammary gland development, this review discusses recently published observations on human breast cancers as well as experimental evidence from genetically engineered mice that propose a dual role of Jak2/Stat5 signaling in breast cancer initiation and progression. Future studies to further test the concept of contrasting effects of Jak2/Stat5 pathway on breast cancer initiation and metastatic progression are proposed.

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Title: Jak2/Stat5 Signaling in Mammogenesis, Breast Cancer Initiation and Progression
Authors: Kay-Uwe Wagner
Hallgeir Rui
Publication date: 01-03-2008
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 1/2008
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-008-9062-z

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