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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-04-2006

Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy

Authors: Mazen Sidani, Jeffrey Wyckoff, Chengsen Xue, Jeffrey E. Segall, John Condeelis

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2/2006

Abstract

Advances in optical imaging technologies that allow the subcellular resolution of undissected tissue have begun to offer new clues into the biology of development and disease. For cancer, such advances mean that the primary tumor is no longer a black box and that the disease can be studied throughout the metastatic cascade and not just as an endpoint. In this review we examine the advances in multiphoton imaging technology that have been used to define the microenvironment and its role in delineating the invasion and intravasation steps of metastasis inside living mammary tumors. Results show that the tumor microenvironment is a dynamic place where interactions between tumor cells, macrophages, blood vessels, and extracellular matrix fibers define the metastatic phenotype.

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Title: Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy
Authors: Mazen Sidani
Jeffrey Wyckoff
Chengsen Xue
Jeffrey E. Segall
John Condeelis
Publication date: 01-04-2006
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 2/2006
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-006-9021-5

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