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Journal of Gambling Studies
Published in: Journal of Gambling Studies 1/2020

Open Access 01-03-2020 | Pathological Gambling | Original Paper

Drugs-Induced Pathological Gambling: An Analysis of Italian Spontaneous Reporting System

Authors: Cristina Scavone, Barbara Stelitano, Concetta Rafaniello, Francesco Rossi, Liberata Sportiello, Annalisa Capuano

Published in: Journal of Gambling Studies | Issue 1/2020

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Abstract

Pathological gambling has been reported as a direct complication of Parkinson’s disease and its pharmacological treatment based on dopamine agonists. Moreover, further medications (not dopamine agonists) were associated to the occurrence of gambling disorder. We aim to analyze the spontaneous reports of gambling disorder on the whole Italian territory with a focus on Campania Region (Southern Italy) from January 1st 2002 to July 31st 2018. We analyzed gambling disorder’s reports across the 2002–2018 period in the Italian spontaneous reporting database (Rete Nazionale di Farmacovigilanza—RNF), with a focus on Campania region. 94 suspected cases of gambling disorder associated to apomorphine, aripiprazole, cabergoline, levodopa, levodopa and derivatives in association with entacapone/benserazide and carbidopa, pergolide, pramipexole, ropinirole, and rotigotine were reported into the RNF. Of these cases, two related to pramipexole and one to aripiprazole were sent to Campania Pharmacovigilance Regional Centre. Although it is widely recognized that dopamine agonists may induce behavioral disorders, Parkinson’s disease is itself associated to pathological gambling, compulsive shopping and eating. Since our results could not clarify the correlation between Parkinson’s disease, its pharmacological treatment and pathological gambling, in order to better define this correlation there is a need to conduct further ad hoc observational studies.
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Metadata
Title
Drugs-Induced Pathological Gambling: An Analysis of Italian Spontaneous Reporting System
Authors
Cristina Scavone
Barbara Stelitano
Concetta Rafaniello
Francesco Rossi
Liberata Sportiello
Annalisa Capuano
Publication date
01-03-2020

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