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Published in: Journal of Genetic Counseling 6/2014

01-12-2014 | Case Presentation

Existing Challenges Associated with Offering Prenatal Genetic Diagnosis in an Arab Society in the Sultanate of Oman

Authors: Zandrè Bruwer, Udayakumar Achandira, Khalsa Al Kharousi, Adila Al-Kindy

Published in: Journal of Genetic Counseling | Issue 6/2014

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Abstract

The incidence of congenital anomalies and/or genetic disorders in the Omani population has reached figures greater than double the global statistics. Preference for consanguineous unions together with the fact that termination of pregnancy in Muslim communities are largely avoided, have been highlighted as contributing factors. This overview identifies a third significant aspect contributing to the elevated rate of genetic disorders in the Omani population. Namely, a lack of services that are able to offer termination of pregnancy for severe congenital anomalies, to requesting parents. In this report we select an unusual case of a family at risk for two distinct genetic disorders - 6q micro-deletion and unbalanced products of conception attributed to a balanced parental translocation involving chromosome 3 and 13, to portray and examine the current situation faced by Omani couples interested in prenatal diagnosis for termination of pregnancy. Additional challenges and pitfalls to developing a prenatal diagnostic service as part of the genetic service in Oman are discussed.
Literature
go back to reference Albar, M. (1999). Counselling about genetic disease: An Islamic perspective. Eastern Mediterranean Health Journal, 5, 1129–1133.PubMed Albar, M. (1999). Counselling about genetic disease: An Islamic perspective. Eastern Mediterranean Health Journal, 5, 1129–1133.PubMed
go back to reference Alkuraya, F. S., & Kilani, R. A. (2001). Attitude of Saudi families affected with hemoglobinopathies towards prenatal screening and abortion and the influence of religious ruling (fatwa). Prenatal Diagnosis, 21, 448–451.PubMedCrossRef Alkuraya, F. S., & Kilani, R. A. (2001). Attitude of Saudi families affected with hemoglobinopathies towards prenatal screening and abortion and the influence of religious ruling (fatwa). Prenatal Diagnosis, 21, 448–451.PubMedCrossRef
go back to reference Alwan, A., Modell, B., & Community control of genetic and congenital disorders. (1997). Eastern Mediterranean regional office technical publication series 24. Alexandria: World Health Organization. Alwan, A., Modell, B., & Community control of genetic and congenital disorders. (1997). Eastern Mediterranean regional office technical publication series 24. Alexandria: World Health Organization.
go back to reference Aramesh, K. (2007). The influences of bioethics and Islamic jurisprudence on policy-making in Iran. American Journal of Biotechnology, 7, 42–44. Aramesh, K. (2007). The influences of bioethics and Islamic jurisprudence on policy-making in Iran. American Journal of Biotechnology, 7, 42–44.
go back to reference Bache, I., Brondum-nielsen, K., & Tommerup, N. (2007). Genetic counseling in adult carriers of a balanced chromosomal rearrangement ascertained in childhood: Experiences from a nationwide reexamination of translocation carriers. Genetics in Medicine, 9(3), 185–187.PubMedCrossRef Bache, I., Brondum-nielsen, K., & Tommerup, N. (2007). Genetic counseling in adult carriers of a balanced chromosomal rearrangement ascertained in childhood: Experiences from a nationwide reexamination of translocation carriers. Genetics in Medicine, 9(3), 185–187.PubMedCrossRef
go back to reference Bittles, A. H., & Hamamy, H. A. (2010). Endogamy and consanguineous marriage in Arab populations. In A. S. Teebi (Ed.), Genetic disorders among Arab populations (2nd ed., pp. 85–108). Berlin-Heidelberg: Springer Verlag.CrossRef Bittles, A. H., & Hamamy, H. A. (2010). Endogamy and consanguineous marriage in Arab populations. In A. S. Teebi (Ed.), Genetic disorders among Arab populations (2nd ed., pp. 85–108). Berlin-Heidelberg: Springer Verlag.CrossRef
go back to reference Gardner, R. J., & Sutherland, G. R. (2004). Chromosome abnormalities and genetic counseling. New York: Oxford University Press. Gardner, R. J., & Sutherland, G. R. (2004). Chromosome abnormalities and genetic counseling. New York: Oxford University Press.
go back to reference Hussain, R. (1999). Community perceptions of reasons for preference for consanguineous marriage in Pakistan. Journal of Biosocial Science, 31, 449–461.PubMedCrossRef Hussain, R. (1999). Community perceptions of reasons for preference for consanguineous marriage in Pakistan. Journal of Biosocial Science, 31, 449–461.PubMedCrossRef
go back to reference Jaber, L., Shohat, T., & Halpern, G. J. (1996). Demographic characteristics of the Israeli Arab community in connection with consanguinity. Israel Journal of Medical Sciences, 32, 1286–1289.PubMed Jaber, L., Shohat, T., & Halpern, G. J. (1996). Demographic characteristics of the Israeli Arab community in connection with consanguinity. Israel Journal of Medical Sciences, 32, 1286–1289.PubMed
go back to reference Jacobs, P. A., Browne, C., Gregson, N., Joyce, C., & White, H. (1992). Estimates of the frequency of chromosome abnormalities detectable in unselected newborns using the moderate levels of banding. Journal of Medical Genetics, 29, 103–108.PubMedCentralPubMedCrossRef Jacobs, P. A., Browne, C., Gregson, N., Joyce, C., & White, H. (1992). Estimates of the frequency of chromosome abnormalities detectable in unselected newborns using the moderate levels of banding. Journal of Medical Genetics, 29, 103–108.PubMedCentralPubMedCrossRef
go back to reference Jafri, H., Ahmed, S., Ahmed, M., Hewison, J., Raashid, Y., & Sheridan, E. (2012). Islam and termination of pregnancy for genetic conditions in Pakistan: Implications for Pakistani health care providers. Prenatal Diagnosis, 32, 1218–1220.PubMedCrossRef Jafri, H., Ahmed, S., Ahmed, M., Hewison, J., Raashid, Y., & Sheridan, E. (2012). Islam and termination of pregnancy for genetic conditions in Pakistan: Implications for Pakistani health care providers. Prenatal Diagnosis, 32, 1218–1220.PubMedCrossRef
go back to reference Khlat, M., Halabi, S., Khudr, A., & Der Kaloustian, V. M. (1986). Perceptions of consanguineous marriages and their genetic effects among a sample of couples from Beirut. American Journal of Medical Genetics, 25, 299–306.PubMedCrossRef Khlat, M., Halabi, S., Khudr, A., & Der Kaloustian, V. M. (1986). Perceptions of consanguineous marriages and their genetic effects among a sample of couples from Beirut. American Journal of Medical Genetics, 25, 299–306.PubMedCrossRef
go back to reference Rajab, A., & Patton, M. A. (2000). A study of consanguinity in the Sultanate of Oman. Annals of Human Biology, 27(3), 321–326.PubMedCrossRef Rajab, A., & Patton, M. A. (2000). A study of consanguinity in the Sultanate of Oman. Annals of Human Biology, 27(3), 321–326.PubMedCrossRef
go back to reference Rajab, A., Al Rashdi, I., & Al, S. Q. (2013). Genetic services and testing in the Sultanate of Oman. Sultanate of Oman steps into modern genetics. Community Genetics. doi:10.1007/s12687-013-0153-1. Rajab, A., Al Rashdi, I., & Al, S. Q. (2013). Genetic services and testing in the Sultanate of Oman. Sultanate of Oman steps into modern genetics. Community Genetics. doi:10.​1007/​s12687-013-0153-1.
go back to reference Sasongko, T. H., Salmi, A. R., Zilfalil, B. A., Albar, M. A., & Hussin, Z. A. M. (2010). Permissibility of prenatal diagnosis and abortion for fetuses with severe genetic disorder: Type 1 spinal muscular atrophy. Annals of Saudi Medicine, 30(6), 427–431.PubMedCentralPubMedCrossRef Sasongko, T. H., Salmi, A. R., Zilfalil, B. A., Albar, M. A., & Hussin, Z. A. M. (2010). Permissibility of prenatal diagnosis and abortion for fetuses with severe genetic disorder: Type 1 spinal muscular atrophy. Annals of Saudi Medicine, 30(6), 427–431.PubMedCentralPubMedCrossRef
go back to reference Shoham-Vardi, I., Weiner, N., Weitzman, D., & Levcovich, A. (2004). Termination of pregnancy: Attitudes and behavior of women in a traditional society. Prenatal Diagnosis, 24, 869–875.PubMedCrossRef Shoham-Vardi, I., Weiner, N., Weitzman, D., & Levcovich, A. (2004). Termination of pregnancy: Attitudes and behavior of women in a traditional society. Prenatal Diagnosis, 24, 869–875.PubMedCrossRef
go back to reference Wentzel, C., Lynch, S. A., Stattin, E. L., Sharkey, F. H., Anneren, G., & Thuresson, A. C. (2010). Interstitial deletions at 6q14.1-q15 associated with obesity, developmental delay and a distinct clinical phenotype. Molecular Syndromol, 1, 75–81.CrossRef Wentzel, C., Lynch, S. A., Stattin, E. L., Sharkey, F. H., Anneren, G., & Thuresson, A. C. (2010). Interstitial deletions at 6q14.1-q15 associated with obesity, developmental delay and a distinct clinical phenotype. Molecular Syndromol, 1, 75–81.CrossRef
Metadata
Title
Existing Challenges Associated with Offering Prenatal Genetic Diagnosis in an Arab Society in the Sultanate of Oman
Authors
Zandrè Bruwer
Udayakumar Achandira
Khalsa Al Kharousi
Adila Al-Kindy
Publication date
01-12-2014
Publisher
Springer US
Published in
Journal of Genetic Counseling / Issue 6/2014
Print ISSN: 1059-7700
Electronic ISSN: 1573-3599
DOI
https://doi.org/10.1007/s10897-014-9764-x

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