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01-02-2013 | Professional Development Paper

NSGC Practice Guideline: Prenatal Screening and Diagnostic Testing Options for Chromosome Aneuploidy

Authors: K. L. Wilson, J. L. Czerwinski, J. M. Hoskovec, S. J. Noblin, C. M. Sullivan, A. Harbison, M. W. Campion, K. Devary, P. Devers, C. N. Singletary

Published in: Journal of Genetic Counseling | Issue 1/2013

Abstract

The BUN and FASTER studies, two prospective multicenter trials in the United States, validated the accuracy and detection rates of first and second trimester screening previously reported abroad. These studies, coupled with the 2007 release of the American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin that endorsed first trimester screening as an alternative to traditional second trimester multiple marker screening, led to an explosion of screening options available to pregnant women. ACOG also recommended that invasive diagnostic testing for chromosome aneuploidy be made available to all women regardless of maternal age. More recently, another option known as Non-invasive Prenatal Testing (NIPT) became available to screen for chromosome aneuploidy. While screening and testing options may be limited due to a variety of factors, healthcare providers need to be aware of the options in their area in order to provide their patients with accurate and reliable information. If not presented clearly, patients may feel overwhelmed at the number of choices available. The following guideline includes recommendations for healthcare providers regarding which screening or diagnostic test should be offered based on availability, insurance coverage, and timing of a patient’s entry into prenatal care, as well as a triage assessment so that a general process can be adapted to unique situations.

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Title: NSGC Practice Guideline: Prenatal Screening and Diagnostic Testing Options for Chromosome Aneuploidy
Authors: K. L. Wilson
J. L. Czerwinski
J. M. Hoskovec
S. J. Noblin
C. M. Sullivan
A. Harbison
M. W. Campion
K. Devary
P. Devers
C. N. Singletary
Publication date: 01-02-2013
Publisher: Springer US
Published in: Journal of Genetic Counseling / Issue 1/2013
Print ISSN: 1059-7700
Electronic ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-012-9545-3

At a glance: The STEP trials

Springer Medicine

NSGC Practice Guideline: Prenatal Screening and Diagnostic Testing Options for Chromosome Aneuploidy

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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