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01-08-2011 | Commentary

Testing of Collegiate Athletes for Sickle Cell Trait: What We, as Genetic Counselors Should Know

Authors: Amy Aloe, Lakshmanan Krishnamurti, Beth Kladny

Published in: Journal of Genetic Counseling | Issue 4/2011

Abstract

In August 2010, the National Collegiate Athletic Association (NCAA) mandated that all of its incoming Division I student-athletes be tested for sickle cell trait. Student-athletes have the additional options to provide proof of a previous sickle cell test result or decline testing, by signing a waiver releasing their institution of liability. This article addresses the origins of the NCAA recommendations, and stresses the importance of proceeding with care. In doing so, it seeks to start a discussion in the genetic counseling community as to what, if any, should our role be?

Baskurt, O. K., Meiselman, H. J., & Bergeron, M. F. (2007). Re: Point: Counterpoint: Sickle cell trait should/should not be considered asymptomatic and as a benign condition during physical activity. Journal of Applied Physiology, 103(6), 2142–2144.PubMedCrossRef

Bonham, V. L., George, J., Dover, M. D., & Brody, L. C. (2010). Screening student athletes for sickle cell trait—a social and clinical experiment. New England Journal of Medicine, 363(11), 997–999.PubMedCrossRef

Connes, P., Hardy-Dessources, M. D., & Hue, O. (2007). Counterpoint: sickle cell trait should not be considered asymptomatic and as a benign condition during physical activity. Journal of Applied Physiology, 103(6), 2138–2141.PubMedCrossRef

Drehner, D., Neuhauser, K. M., Neuhauser, T. S., & Blackwood, G. V. (1999). Death among U.S. Air Force basic trainees, 1956 to 1996. Military Medicine, 164(12), 841–847.PubMed

Eichner, E. R. (2007). Sickle cell trait. Journal of Sport Rehabilitation, 16(3), 197–203.PubMed

Gardner, J. W., & Kark, J. A. (1994). Fatal rhabdomyolysis presenting as mild heat illness in military training. Military Medicine, 159(2), 160–163.PubMed

Jones, S. R., Binder, R. A., & Donowho, E. M., Jr. (1970). Sudden death in sickle-cell trait. New England Journal of Medicine, 282(6), 323–325.PubMedCrossRef

Kark, J. A., Posey, D. M., Schumacher, H. R., & Ruehle, C. J. (1987). Sickle-cell trait as a risk factor for sudden death in physical training. New England Journal of Medicine, 317(13), 781–787.PubMedCrossRef

Le Gallais, D., Lonsdorfer, J., Bogui, P., & Fattoum, S. (2007). Point: sickle cell trait should be considered asymptomatic and as a benign condition during physical activity. Journal of Applied Physiology, 103(6), 2137–2141.PubMedCrossRef

Levere, R. D., Lichtman, H. C., & Levine, J. (1964). Effect of iron-deficiency anaemia on the metabolism of the heterogenic haemoglobins in sickle cell trait. Nature, 202, 499–501.PubMedCrossRef

Martin, T. W., Weisman, I. M., Zeballos, R. J., & Stephenson, S. R. (1989). Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait. American Journal of Medicine, 87(1), 48–56.PubMedCrossRef

Mitchell, B. L. (2007). Sickle cell trait and sudden death-bringing it home. Journal of the National Medical Association, 99(3), 300–305.PubMed

National Collegiate Athletic Association (NCAA). “2010–2011 Sports Medicine Handbook,” ncaa.org, February 10, 2011, pg 87.

Noguchi, C. T., Torchia, D. A., & Schechter, A. N. (1981). Polymerization of hemoglobin in sickle trait erythrocytes and lysates. Journal of Biological Chemistry, 256(9), 4168–4171.PubMed

Rywlin, A. M., & Benson, J. (1961). Massive necrosis of the spleen with formation of a pseudocyst. Report of a case in a white man with sickle cell trait. American Journal of Clinical Pathology, 36, 142–150.PubMed

Sheikha, A. (2005). Splenic syndrome in patients at high altitude with unrecognized sickle cell trait: splenectomy is often unnecessary. Canadian Journal of Surgery, 48(5), 377–381.

Tsaras, G., Owusu-Ansah, A., Boateng, F. O., & Amoateng-Adjepong, Y. (2009). Complications associated with sickle cell trait: a brief narrative review. American Journal of Medicine, 122(6), 507–512.PubMedCrossRef

Wilson B. NCAA may force schools to test for sickle cell trait (transcript). (December 28, 2009). National Public Radio, (Accessed March 6, 2009 at http://www.npr.org/templates/story.php?storyId=121963774.)

Title: Testing of Collegiate Athletes for Sickle Cell Trait: What We, as Genetic Counselors Should Know
Authors: Amy Aloe
Lakshmanan Krishnamurti
Beth Kladny
Publication date: 01-08-2011
Publisher: Springer US
Published in: Journal of Genetic Counseling / Issue 4/2011
Print ISSN: 1059-7700
Electronic ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-011-9366-9

At a glance: The STEP trials

Springer Medicine

Testing of Collegiate Athletes for Sickle Cell Trait: What We, as Genetic Counselors Should Know

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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