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Published in: Journal of Clinical Psychology in Medical Settings 2/2013

01-06-2013

Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis

Authors: Luca Ostacoli, Sara Carletto, Martina Borghi, Marco Cavallo, Emanuela Rocci, Marco Zuffranieri, Simona Malucchi, Antonio Bertolotto, Alessandro Zennaro, Pier Maria Furlan, Rocco Luigi Picci

Published in: Journal of Clinical Psychology in Medical Settings | Issue 2/2013

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Abstract

Chronic and life-threatening neurodegenerative diseases may be associated with post-traumatic stress disorder (PTSD). Therefore, the current study was an investigation of the prevalence of PTSD in multiple sclerosis (MS) patients, and identification of significant determinants of PTSD. Two hundred thirty-two MS patients were consecutively recruited and screened for the presence of PTSD with the Impact of Event Scale-Revised, corroborated by the Structured Clinical Interview for DSM-IV. Furthermore, participants were administered the Hospital Anxiety and Depression Scale and the Fatigue Severity Scale. Twelve patients (12/232, i.e. 5.17 %) were diagnosed as suffering from PTSD. Levels of education, anxiety and depression were significant determinants of the presence of PTSD. The role played by the levels of education, anxiety and depression in determining the presence of PTSD has been discussed. Further research on the psychological features of neurodegenerative diseases is urgently needed in order to plan appropriate treatments and improve patients’ quality of life.
Literature
go back to reference American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., Text Revision). Washington, DC: Author. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., Text Revision). Washington, DC: Author.
go back to reference Behari, M., Srivastava, A. K., & Pandey, R. M. (2005). Quality of life in patients with Parkinson’s disease. Parkinsonism and Related Disorders, 11, 221–226.PubMedCrossRef Behari, M., Srivastava, A. K., & Pandey, R. M. (2005). Quality of life in patients with Parkinson’s disease. Parkinsonism and Related Disorders, 11, 221–226.PubMedCrossRef
go back to reference Beiske, A. G., Svensson, E., Sandanger, I., Czujko, B., Pedersen, E. D., Aarseth, J. H., et al. (2008). Depression and anxiety amongst multiple sclerosis patients. European Journal of Neurology, 15, 239–245.PubMedCrossRef Beiske, A. G., Svensson, E., Sandanger, I., Czujko, B., Pedersen, E. D., Aarseth, J. H., et al. (2008). Depression and anxiety amongst multiple sclerosis patients. European Journal of Neurology, 15, 239–245.PubMedCrossRef
go back to reference Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., et al. (1995). The development of a Clinician Administered PTSD Scale. Journal of Traumatic Stress, 8, 75–90.PubMedCrossRef Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., et al. (1995). The development of a Clinician Administered PTSD Scale. Journal of Traumatic Stress, 8, 75–90.PubMedCrossRef
go back to reference Brewin, C. R., Andrews, B., & Valentine, J. D. (2000). Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. Journal of Consulting and Clinical Psychology, 68, 748–766.PubMedCrossRef Brewin, C. R., Andrews, B., & Valentine, J. D. (2000). Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. Journal of Consulting and Clinical Psychology, 68, 748–766.PubMedCrossRef
go back to reference Briere, J. (1997). Psychological assessment of adult posttraumatic states. Washington, DC: American Psychological Association.CrossRef Briere, J. (1997). Psychological assessment of adult posttraumatic states. Washington, DC: American Psychological Association.CrossRef
go back to reference Chalfant, A. M., Bryant, R. A., & Fulcher, G. (2004). Posttraumatic stress disorder following diagnosis of multiple sclerosis. Journal of Traumatic Stress, 17, 423–428.PubMedCrossRef Chalfant, A. M., Bryant, R. A., & Fulcher, G. (2004). Posttraumatic stress disorder following diagnosis of multiple sclerosis. Journal of Traumatic Stress, 17, 423–428.PubMedCrossRef
go back to reference Chiaravalloti, N. D., & DeLuca, J. (2008). Cognitive impairment in multiple sclerosis. Lancet Neurology, 7, 1139–1151.PubMedCrossRef Chiaravalloti, N. D., & DeLuca, J. (2008). Cognitive impairment in multiple sclerosis. Lancet Neurology, 7, 1139–1151.PubMedCrossRef
go back to reference Chiovetti, A. (2006). Bridging the gap between health literacy and patient education for people with multiple sclerosis. Journal of Neuroscience Nursing, 38, 374–378.PubMedCrossRef Chiovetti, A. (2006). Bridging the gap between health literacy and patient education for people with multiple sclerosis. Journal of Neuroscience Nursing, 38, 374–378.PubMedCrossRef
go back to reference Cordova, M. J., Giese-Davis, J., Golant, M., Kronenwetter, C., Chang, V., & Spiegel, D. (2007). Breast cancer as trauma: Posttraumatic stress and posttraumatic growth. Journal of Clinical Psychology in Medical Settings, 14, 308–319.CrossRef Cordova, M. J., Giese-Davis, J., Golant, M., Kronenwetter, C., Chang, V., & Spiegel, D. (2007). Breast cancer as trauma: Posttraumatic stress and posttraumatic growth. Journal of Clinical Psychology in Medical Settings, 14, 308–319.CrossRef
go back to reference Dell’Osso, L., & Carmassi, C. (2011). PTSD 30 years after DSM-III: Current controversies and future challenges. Italian Journal of Psychopathology, 17, 1–4. Dell’Osso, L., & Carmassi, C. (2011). PTSD 30 years after DSM-III: Current controversies and future challenges. Italian Journal of Psychopathology, 17, 1–4.
go back to reference Esch, T., Stefano, G. B., Fricchione, G. L., & Benson, H. (2002). The role of stress in neurodegenerative diseases and mental disorders. Neuroendocrinology Letters, 23, 199–208.PubMed Esch, T., Stefano, G. B., Fricchione, G. L., & Benson, H. (2002). The role of stress in neurodegenerative diseases and mental disorders. Neuroendocrinology Letters, 23, 199–208.PubMed
go back to reference First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. (1996). Structured Clinical Interview for DSM-IV axis I disorders, clinician version (SCID-CV). Washington, DC: American Psychiatric Press. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. (1996). Structured Clinical Interview for DSM-IV axis I disorders, clinician version (SCID-CV). Washington, DC: American Psychiatric Press.
go back to reference Hathaway, L. M., Boals, A., & Banks, J. B. (2010). PTSD symptoms and dominant emotional response to a traumatic event: An examination of DSM-IV Criterion A2. Anxiety Stress Coping, 23, 119–126.PubMedCrossRef Hathaway, L. M., Boals, A., & Banks, J. B. (2010). PTSD symptoms and dominant emotional response to a traumatic event: An examination of DSM-IV Criterion A2. Anxiety Stress Coping, 23, 119–126.PubMedCrossRef
go back to reference Honarmand, K., & Feinstein, A. (2009). Validation of the Hospital Anxiety and Depression Scale for use with multiple sclerosis patients. Multiple Sclerosis, 15, 1518–1524.PubMedCrossRef Honarmand, K., & Feinstein, A. (2009). Validation of the Hospital Anxiety and Depression Scale for use with multiple sclerosis patients. Multiple Sclerosis, 15, 1518–1524.PubMedCrossRef
go back to reference Horowitz, M., Wilner, N., & Alvarez, W. (1979). Impact of Event Scale: A measure of subjective stress. Psychosomatic Medicine, 41, 209–218.PubMed Horowitz, M., Wilner, N., & Alvarez, W. (1979). Impact of Event Scale: A measure of subjective stress. Psychosomatic Medicine, 41, 209–218.PubMed
go back to reference Kangas, M., Henry, J. L., & Bryant, R. A. (2002). Posttraumatic stress disorder following cancer: A conceptual and empirical review. Clinical Psychology Review, 22, 499–524.PubMedCrossRef Kangas, M., Henry, J. L., & Bryant, R. A. (2002). Posttraumatic stress disorder following cancer: A conceptual and empirical review. Clinical Psychology Review, 22, 499–524.PubMedCrossRef
go back to reference Krupp, L. B., LaRocca, N. G., Muir-Nash, J., & Steinberg, A. D. (1989). The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology, 46, 1121–1123.PubMedCrossRef Krupp, L. B., LaRocca, N. G., Muir-Nash, J., & Steinberg, A. D. (1989). The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology, 46, 1121–1123.PubMedCrossRef
go back to reference Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS). Neurology, 33, 1444–1452.PubMedCrossRef Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS). Neurology, 33, 1444–1452.PubMedCrossRef
go back to reference McCabe, M. (2006). A longitudinal study of coping strategies and quality of life among people with multiple sclerosis. Journal of Clinical Psychology in Medical Settings, 13, 367–377.CrossRef McCabe, M. (2006). A longitudinal study of coping strategies and quality of life among people with multiple sclerosis. Journal of Clinical Psychology in Medical Settings, 13, 367–377.CrossRef
go back to reference McCabe, M. P., & McKern, S. (2002). Quality of life and multiple sclerosis: Comparison between people with multiple sclerosis and people from the general population. Journal of Clinical Psychology in Medical Settings, 9, 287–295.CrossRef McCabe, M. P., & McKern, S. (2002). Quality of life and multiple sclerosis: Comparison between people with multiple sclerosis and people from the general population. Journal of Clinical Psychology in Medical Settings, 9, 287–295.CrossRef
go back to reference McCabe, M. P., McKern, S., & McDonald, E. (2004). Coping and psychological adjustment among people with multiple sclerosis. Journal of Psychosomatic Research, 56, 355–361.PubMedCrossRef McCabe, M. P., McKern, S., & McDonald, E. (2004). Coping and psychological adjustment among people with multiple sclerosis. Journal of Psychosomatic Research, 56, 355–361.PubMedCrossRef
go back to reference Mohr, D. C., Dick, L. P., Russo, D., Penn, J., Boudewyn, A. C., Liposky, W., et al. (1999). The psychosocial impact of multiple sclerosis: Exploring the patient’s perspective. Health Psychology, 18, 376–382.PubMedCrossRef Mohr, D. C., Dick, L. P., Russo, D., Penn, J., Boudewyn, A. C., Liposky, W., et al. (1999). The psychosocial impact of multiple sclerosis: Exploring the patient’s perspective. Health Psychology, 18, 376–382.PubMedCrossRef
go back to reference Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., et al. (2011). Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Annals of Neurology, 69, 292–302.PubMedCrossRef Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., et al. (2011). Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Annals of Neurology, 69, 292–302.PubMedCrossRef
go back to reference Possemato, K. (2011). The current state of intervention research for posttraumatic stress disorder within the primary care setting. Journal of Clinical Psychology in Medical Settings, 18, 268–280.PubMedCrossRef Possemato, K. (2011). The current state of intervention research for posttraumatic stress disorder within the primary care setting. Journal of Clinical Psychology in Medical Settings, 18, 268–280.PubMedCrossRef
go back to reference Qureshi, S. U., Kimbrell, T., Pyne, J. M., Magruder, K. M., Hudson, T. J., Petersen, N. J., et al. (2010). Greater prevalence and incidence of dementia in older veterans with posttraumatic stress disorder. Journal of American Geriatrics Society, 58, 1627–1633.CrossRef Qureshi, S. U., Kimbrell, T., Pyne, J. M., Magruder, K. M., Hudson, T. J., Petersen, N. J., et al. (2010). Greater prevalence and incidence of dementia in older veterans with posttraumatic stress disorder. Journal of American Geriatrics Society, 58, 1627–1633.CrossRef
go back to reference Raboni, M. R., Tufik, S., & Suchecki, D. (2006). Treatment of PTSD by eye movement desensitization reprocessing (EMDR) improves sleep quality, quality of life, and perception of stress. Annals of New York Academy of Sciences, 1071, 508–513.CrossRef Raboni, M. R., Tufik, S., & Suchecki, D. (2006). Treatment of PTSD by eye movement desensitization reprocessing (EMDR) improves sleep quality, quality of life, and perception of stress. Annals of New York Academy of Sciences, 1071, 508–513.CrossRef
go back to reference Sperling, W., Kreil, S. K., & Biermann, T. (2011). Posttraumatic stress disorder and dementia in holocaust survivors. Journal of Nervous and Mental Diseases, 199, 196–198.CrossRef Sperling, W., Kreil, S. K., & Biermann, T. (2011). Posttraumatic stress disorder and dementia in holocaust survivors. Journal of Nervous and Mental Diseases, 199, 196–198.CrossRef
go back to reference Tedstone, J. E., & Tarrier, N. (2003). Posttraumatic stress disorder following medical illness and treatment. Clinical Psychology Review, 23, 409–448.PubMedCrossRef Tedstone, J. E., & Tarrier, N. (2003). Posttraumatic stress disorder following medical illness and treatment. Clinical Psychology Review, 23, 409–448.PubMedCrossRef
go back to reference Ullman, S. E., & Filipas, H. H. (2001). Predictors of PTSD symptoms severity and social reactions in sexual assault victims. Journal of Traumatic Stress, 14, 369–389.PubMedCrossRef Ullman, S. E., & Filipas, H. H. (2001). Predictors of PTSD symptoms severity and social reactions in sexual assault victims. Journal of Traumatic Stress, 14, 369–389.PubMedCrossRef
go back to reference van der Kolk, B. A., Spinazzola, J., Blaustein, M. E., Hopper, J. W., Hopper, E. K., Korn, D. L., et al. (2007). A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: Treatment effects and long-term maintenance. Journal of Clinical Psychiatry, 68, 37–46.PubMedCrossRef van der Kolk, B. A., Spinazzola, J., Blaustein, M. E., Hopper, J. W., Hopper, E. K., Korn, D. L., et al. (2007). A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: Treatment effects and long-term maintenance. Journal of Clinical Psychiatry, 68, 37–46.PubMedCrossRef
go back to reference Vasterling, J. J., Duke, L. M., Brailey, K., Constans, J. I., Allain, A. N., & Sutker, P. B. (2002). Attention, learning, and memory performances and intellectual resources in Vietnam veterans: pTSD and no disorders comparisons. Neuropsychology, 16, 5–14.PubMedCrossRef Vasterling, J. J., Duke, L. M., Brailey, K., Constans, J. I., Allain, A. N., & Sutker, P. B. (2002). Attention, learning, and memory performances and intellectual resources in Vietnam veterans: pTSD and no disorders comparisons. Neuropsychology, 16, 5–14.PubMedCrossRef
go back to reference Weiss, D. S., & Marmar, C. R. (1997). The Impact of Event Scale-Revised. In J. P. Wilson & T. M. Keane (Eds.), Assessing psychological trauma and PTSD (pp. 399–411). New York: Guilford. Weiss, D. S., & Marmar, C. R. (1997). The Impact of Event Scale-Revised. In J. P. Wilson & T. M. Keane (Eds.), Assessing psychological trauma and PTSD (pp. 399–411). New York: Guilford.
go back to reference Patti, F., Pozzilli, C., Montanari, E., Pappalardo, A., Piazza, L., Levi, A., Onesti, E., Pesci, I; Italian Study Group on Quality of Life in MS. (2007). Effects of education level and employment status on HRQoL in early relapsing-remitting multiple sclerosis. Multiple Sclerosis, 13, 783–791. Patti, F., Pozzilli, C., Montanari, E., Pappalardo, A., Piazza, L., Levi, A., Onesti, E., Pesci, I; Italian Study Group on Quality of Life in MS. (2007). Effects of education level and employment status on HRQoL in early relapsing-remitting multiple sclerosis. Multiple Sclerosis, 13, 783–791.
go back to reference Yaffe, K., Vittinghoff, E., Lindquist, K., Barnes, D., Covinsky, K. E., Neylan, T., et al. (2010). Post-traumatic stress disorder and risk of dementia among U.S. Veterans. Archives of General Psychiatry, 67, 608–613.PubMedCrossRef Yaffe, K., Vittinghoff, E., Lindquist, K., Barnes, D., Covinsky, K. E., Neylan, T., et al. (2010). Post-traumatic stress disorder and risk of dementia among U.S. Veterans. Archives of General Psychiatry, 67, 608–613.PubMedCrossRef
go back to reference Zigmond, A. S., & Snaith, R. P. (1983). The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica, 67, 361–370.PubMedCrossRef Zigmond, A. S., & Snaith, R. P. (1983). The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica, 67, 361–370.PubMedCrossRef
Metadata
Title
Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis
Authors
Luca Ostacoli
Sara Carletto
Martina Borghi
Marco Cavallo
Emanuela Rocci
Marco Zuffranieri
Simona Malucchi
Antonio Bertolotto
Alessandro Zennaro
Pier Maria Furlan
Rocco Luigi Picci
Publication date
01-06-2013
Publisher
Springer US
Published in
Journal of Clinical Psychology in Medical Settings / Issue 2/2013
Print ISSN: 1068-9583
Electronic ISSN: 1573-3572
DOI
https://doi.org/10.1007/s10880-012-9323-2

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