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01-12-2006 | Original Paper

Panacea or Placebo: The Historical Quest for Medications to Treat Depression

Author: James C. Overholser

Published in: Journal of Contemporary Psychotherapy | Issue 4/2006

Abstract

Background: Over the years, there have been many advances in contemporary medicine and the ability to treat depression with medications. However, some innovative practices in medical treatments appear less than ideal when viewed from a historical perspective. Aims: It is important for health care professionals to appreciate the risks and limitations of a biological approach to an emotional disorder. Conclusions: If professionals can learn from past mistakes, they can better evaluate the merits of contemporary treatments.

Agosti, V., Stewart, J. W., Quitkin, F. M., & Ocepek-Welikson, K. (1993). How symptomatic do depressed patients remain after benefiting from medication treatment? Comprehensive Psychiatry, 34, 182–186.PubMedCrossRef

Allison, H. E. (1897). Simple melancholia and its treatment. Medical Record, 51, 39–41.

Altschule, M. D., & Tillotson, K. J. (1948). The use of testosterone in the treatment of depressions. New England Journal of Medicine, 239, 1036–1038.PubMedCrossRef

Ambrosini, P. J., Bianchi, M. D., Rabinovich, H., & Elia, J. (1993). Antidepressant treatments in children and adolescents: I. Affective disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 1–6.PubMedCrossRef

American Psychiatric Association. (2000). Practice guidelines for the treatment of patients with Major Depressive Disorder (Revision). American Journal of Psychiatry, 157(supplement), 1–45.

Antonuccio, D. O., Danton, W. G., & DeNelsky, G. Y., Greenberg, R. P., & Gordon, J. S. (1999). Raising questions about antidepressants. Psychotherapy and Psychosomatics, 68, 3–14.PubMedCrossRef

Blake, J. E., & Hamilton, A. M. (1880). A preliminary report upon the use of dilute nitrous oxide gas in the treatment of melancholia and nervous exhaustion. Lancet, 17, 118.

Bos, C., & Lehmann, H. (1950). Studies on psychiatric patients undergoing nitrous oxide treatments. Journal of Mental Science, 96, 509–513.PubMed

Bowman, K. M., & Bender, L. (1932). The treatment of involution melancholia with ovarian hormone. American Journal of Psychiatry, 11, 869–893.

Brigham, A. (1842). Medical treatment of insanity. Boston Medical and Surgical Journal, 26, 389–390.

Brigham, A. (1846). The medical treatment of insanity. American Journal of Insanity, 3, 353–358.

Brugha, T., Bebbington, P., MacCarthy, B., Surt, E., & Wykes, T. (1992). Antidepressants may not assist recovery in practice: A naturalistic prospective survey. Acta Psychiatrica Scandinavica, 86, 5–11.PubMed

Byrne, S. E., & Rothschild, A. J. (1998). Loss of antidepressant efficacy during maintenance therapy: Possible mechanisms and treatments. Journal of Clinical Psychiatry, 59, 279–288.PubMed

Cheadle, W. B. (1894). The clinical uses of opium. The Clinical Journal, 4, 345–351.

Courtenay, E. M. (1872). The use of opium in the treatment of melancholia. West Riding Lunatic Asylum Medical Reports, 2, 254–277.

Danziger, L. (1942). Estrogen therapy of agitated depressions associated with the menopause. Archives of Neurology and Psychiatry, 47, 305–313.

Danziger, L., & Blank, H. R. (1942). Androgen therapy of agitated depressions in the male. Medical Annals of the District of Columbia, 11, 181–183.

Danziger, L., Schroeder, H. T., & Unger, A. A. (1944). Androgen therapy for involutional melancholia. Archives of Neurology and Psychiatry, 51, 457–461.

Demyttenaere, K., Enzlin, P., Dewe, W., Boulanger, B., DeBie, J., Troyer, W., & Mesters, P. (2001). Compliance with antidepressants in a primary care setting, 1: Beyond lack of efficacy and adverse events. Journal of Clinical Psychiatry, 62(Suppl 22), 30–33.PubMed

Denber, H., & Merlis, S. (1954). A note on some therapeutic implications of the mescaline-induced state. Psychiatric Quarterly, 28, 635–640.CrossRef

Dording, C. (2000). Antidepressant augmentation and combinations. Psychiatric Clinics of North America, 23, 743–755.PubMedCrossRef

Dubois, P. (1905). The psychic treatment of nervous disorders. New York: Funk & Wagnalls.

Fava, G. (2002). Long-term treatment with antidepressant drugs: The spectacular achievements of propaganda. Psychotherapy and Psychosomatics, 71, 127–132.CrossRef

Fava, G. A., Savron, G., Grandi, S., & Rafanelli, C. (1997). Cognitive-behavioral management of drug-resistant major depressive disorder. Journal of Clinical Psychiatry, 58, 278–282.PubMed

Gray, J. P. (1859). On the use of cannabis indica in the treatment of insanity. American Journal of Insanity, 16, 80–89.

Greenberg, R. P., & Fisher, S. (1997). Mood-mending medicines: Probing drug, psychotherapy, and placebo solutions. In S. Fisher & R. Greenberg (Eds.), From placebo to panacea: Putting psychiatric drugs to the test (pp. 115–172). New York: Wiley.

Greisinger, W. (1965). Mental pathology and therapeutics. New York: Hafner. (original work published 1867).

Heiman, M. (1942). On the use of strychnine in the curare-aided metrazol treatment of psychoses. American Journal of Psychiatry, 99, 706–711.

Hirschfeld, R. M. (2001). Clinical importance of long-term antidepressant treatment. British Journal of Psychiatry, 179(suppl.), s4–s8.CrossRef

Hughes, C. H. (1886). An outline brief in the management of melancholia. Alienist and Neurologist, 7, 217–236.

Joffe, R., Sokolov, S., & Streiner, D. (1996). Antidepressant treatment of depression: A metaanalysis. Canadian Journal of Psychiatry, 41, 613–616.

Jones, H. L. (1885). Notes on cannabis indica as a narcotic. The Practitioner, 15, 251.

Keller, M., & Boland, R. (1998). Implications of failing to achieve successful long-term maintenance treatment of recurrent unipolar depression. Biological Psychiatry, 44, 348–360.PubMedCrossRef

Kessler, R., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K., Rush, A. J., Walters, E., & Wang, P. (2003). The epidemiology of Major Depressive Disorder. Journal of the American Medical Association, 289, 3095–3105.PubMedCrossRef

Kirsch, I., & Sapirstein, G. (1998). Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication. Prevention and Treatment, 1, 1–18.

Kitchen, D. H. (1873). Conium in the treatment of insanity. American Journal of Insanity, 29, 457–480.

Kuh, S. (1918). Melancholia. Journal of Nervous and Mental Disease, 47, 411–417.CrossRef

Kupfer, D. J. (1992). Maintenance treatment in recurrent depression: Current and future directions. British Journal of Psychiatry, 161, 309–316.PubMed

Lehmann, H. (1960). Combined pharmaco-fever treatment with imipramine (Tofranil) and typhoid vaccine in the management of depressive conditions. American Journal of Psychiatry, 117, 356–358.PubMed

Lehmann, H., & Bos, C. (1947). The advantages of nitrous oxide inhalation in psychiatric treatment. American Journal of Psychiatry, 104, 164–170.PubMed

Leuchter, A. F., Cook, I. A., Witte, E. A., Morgan, M., & Abrams, M. (2002). Changes in brain function of depressed subjects during treatment with placebo. American Journal of Psychiatry, 159, 122–129.PubMedCrossRef

Lipowski, Z. (1989). Psychiatry: Mindless or brainless, both or neither? Canadian Journal of Psychiatry, 34, 249–254.

Masand, P., Anand, V., & Tanquary, J. (1998). Psychostimulant augmentation of second generation antidepressants: A case series. Depression and Anxiety, 7, 89–91.PubMedCrossRef

Maudsley, H. (1869). On opium in the treatment of insanity. The Practitioner, 2, 1–8.

Moncrieff, J. (2001). Are antidepressants overrated? A review of methodological problems in antidepressant trials. Journal of Nervous and Mental Disease, 189, 288–295.PubMedCrossRef

Moncrieff, J. (2002). The antidepressant debate. British Journal of Psychiatry, 180, 193–194.PubMedCrossRef

Moncrieff, J., Wessely, S., & Hardy, R. (1998). Meta-analysis of trials comparing antidepressants with active placebos. British Journal of Psychiatry, 172, 227–231.PubMedCrossRef

Monro, A. B., & Conitzer, H. (1950). A comparison of desoxyephedrine (methedrine) and electroshock in the treatment of depression. Journal of Mental Science, 96, 1037–1042.PubMed

Nestler, E. (1998). Antidepressant treatments in the 21st century. Biological Psychiatry, 44, 526–533.PubMedCrossRef

Noble, D. (1857). On the use of opium in the treatment of insanity. Asylum Journal, 4, 111–118.

Nuckolls, L. J. (1897). Treatment of melancholia with opium. Medical Record, 51, 880.

Olfson, M., Marcus, S. C., Druss, B., Elinson, L., Tanielian, T., & Pincus, H. A. (2002). National trends in the outpatient treatment of depression. Journal of the American Medical Association, 287, 203–209.PubMedCrossRef

Palmer, H. D., Hastings, D. W., & Sherman, S. H. (1941). Therapy in involutional melancholia. American Journal of Psychiatry, 97, 1086–1115.

Pampallona, S., Bollini, P., Tibaldi, G., Kupelnick, B., & Munizza, C. (2004). Combined pharmacotherapy and psychological treatment for depression. Archives of General Psychiatry, 61(7), 714–719.PubMedCrossRef

Parker, G., Roy, K., Wilhelm, K., & Mitchell, P. (2001). Assessing the comparative effectiveness of antidepressant therapies: A prospective clinical practice study. Journal of Clinical Psychiatry, 62, 117–125.PubMedCrossRef

Parker, C. S., & Wrigley, F. (1950). Synthetic cannabis preparations in psychiatry. Journal of Mental Science, 96, 276–279.

Persons, J. B., Thase, M. E., & Crits-Christoph, P. (1996). The role of psychotherapy in the treatment of depression: Review of two practice guidelines. Archives of General Psychiatry, 53, 283–290.PubMed

Pinel, P. (1806). A treatise on insanity. London: Sheffield.

Pope, H., Cohane, G., Kanayama, G., Siegel, A., & Hudson, J. (2003). Testosterone gel supplementation for men with refractory depression: A randomized placebo-controlled trial. American Journal of Psychiatry, 160, 105–111.PubMedCrossRef

Posternak, M., & Miller, I. (2001). Untreated short-term course of major depression. Journal of Affective Disorders, 66, 139–146.PubMedCrossRef

Posternak, M., Zimmerman, M., Keitner, G., & Miller, I. (2002). A reevaluation of the exclusion criteria used in antidepressant efficacy trials. American Journal of Psychiatry, 159, 191–200.PubMedCrossRef

Procopio, M. (2005). The multiple outcomes bias in antidepressant research. Medical Hypotheses, 65(2), 395–399.PubMedCrossRef

Reimherr, F., Strong, R., Marchant, B., Hedges, D., & Wender, P. (2001). Factors affecting return of symptoms 1 year after treatment in a 62-week controlled study of fluoxetine in major depression. Journal of Clinical Psychiatry, 62(suppl 22), 16–23.PubMed

Reynolds, J. R. (1890). Therapeutical uses and toxic effects of cannabis indica. Lancet, 1, 637–638.CrossRef

Richardson, A. B. (1891). Simple melancholia and its treatment. Medical News, 58, 685–689.

Rudolf, G. (1949). The treatment of depression with desoxyephedrine (methedrine). Journal of Mental Science, 95, 920–929.

Rudolf, G. (1955). Treatment of depression with sympathomimetic preparations. The Practitioner, 174, 180–183.

Rudolf, G. (1956). The treatment of depression with methylamphetamine. Journal of Mental Science, 102, 358–363.

Rush, B. (1812). Medical inquiries and observations upon the diseases of the mind. Philadelphia: Kimer & Richardson.

Russell, I. (1881). Melancholia. Alienist and Neurologist, 2, 195–207.

Safer, D. (2002). Design and reporting modifications in industry-sponsored comparative psychopharmacology trials. Journal of Nervous and Mental Disease, 190, 583–592.PubMedCrossRef

Sandison, R., Spencer, A., & Whitelaw, J. (1954). The therapeutic value of Lysergic Acid Diethylamide in mental illness. Journal of Mental Science, 100, 491–507.PubMed

Savage, C. (1952). Lysergic Acid Diethylamide (LSD-25): A clinical-psychological study. American Journal of Psychiatry, 108, 896–900.PubMed

Smith, G., Clarke, D., Handrinos, D., & Trauer, T. (2002). Adverse reactions to antidepressants in consultation-liaison psychiatry inpatients. Psychosomatics, 43, 228–233.PubMedCrossRef

Smith, W. (1912). On the use of brain extract in the treatment of various forms of insanity. British Medical Journal, 2, 1451–1454.

Sommers-Flanagan, J., & Sommers-Flanagan, R. (1996). Efficacy of antidepressant medication with depressed youth: What psychologists should know. Professional Psychology: Research and Practice, 27, 145–153.CrossRef

Stockings, G. T. (1947). A new euphoriant for depressive mental states. British Medical Journal, 1, 918–922.CrossRefPubMed

Stockton, G. (1901). Melancholia and its treatment. Philadelphia Medical Journal, 8, 571–573.

Swindle, R. W., Cronkite, R. C., & Moos, R. H. (1998). Risk factors for sustained nonremission of depressive symptoms: A 4-year follow-up. Journal of Nervous and Mental Disease, 186, 462–469.PubMedCrossRef

Thase, M. E., & Kupfer, D. J. (1996). Recent developments in the pharmacotherapy of mood disorders. Journal of Consulting and Clinical Psychology, 64, 646–659.PubMedCrossRef

Thase, M. E., & Rush, A. J. (1997). When at first you don't succeed: Sequential strategies for antidepressant nonresponders. Journal of Clinical Psychiatry, 58(Suppl 13), 23–29.PubMed

Wells, K. B., Burnham, A., Rogers, W., Hays, W., & Camp, P. (1992). The course of depression in adult outpatients: Results from the Medical Outcomes Study. Archives of General Psychiatry, 49, 788–794.PubMed

Whittington, C., Kendall, T., Fonagy, P., Cottrell, D., Cotgrove, A., & Boddington, E. (2004). Selective serotonin reuptake inhibitors in childhood depression. Lancet, 363, 1341–1345.PubMedCrossRef

Woodward, S. (1850). Observations on the medical treatment of insanity. American Journal of Insanity, 7, 1–34.

Young, G. (1963). A treatise on opium, founded upon practical observation. Reprinted in R. Hunter & I. MacAlpine (Eds.), Three hundred years of psychiatry: 1535–1860, (pp. 395–398). New York: Oxford University Press. (original work published 1753).

Ziehen, T. (1897). The diagnosis and treatment of melancholia. American Journal of Insanity, 54, 579–587.

Title: Panacea or Placebo: The Historical Quest for Medications to Treat Depression
Author: James C. Overholser
Publication date: 01-12-2006
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Journal of Contemporary Psychotherapy / Issue 4/2006
Print ISSN: 0022-0116
Electronic ISSN: 1573-3564
DOI: https://doi.org/10.1007/s10879-006-9023-z

At a glance: The STEP trials

Springer Medicine

Panacea or Placebo: The Historical Quest for Medications to Treat Depression

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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