Skip to main content
Top
Published in: Journal of Clinical Monitoring and Computing 4/2021

01-08-2021 | Liver Resection | Original Research

Renal resistive index as a predictor of postoperative complications in liver resection surgery. Observational study

Authors: Enrico Giustiniano, Fabio Procopio, Emanuela Morenghi, Yari Gollo, Laura Rocchi, Nadia Ruggieri, Valeria Lascari, Guido Torzilli, Maurizio Cecconi

Published in: Journal of Clinical Monitoring and Computing | Issue 4/2021

Login to get access

Abstract

Mortality after liver surgery reduced during the last three decades to less than 2%, but post-operative morbidity occurs in 20–50% of cases. Patients are often considered eligible for post-operative intensive-care unit (ICU) admission. Predicting which patients that are at higher risk could lead to a more precise perioperative management. We investigated whether renal resistive index (RRI), alone or along with other items, can predict post-operative complication after hepatic resection. All consecutive patients undergoing hepatectomy for primary or metastatic neoplasm at our Institution between February 2015 and March 2017 were enrolled. They received RRI measurement before entering in operative room and after awakening from general anesthesia. 183 Patients were enrolled. High surgical invasiveness, surgery time > 360 min, pre-operative RRI and postoperative serum lactate clearance <  − 6%, showed to be associated with postoperative complications. Pre-operative RRI, complex liver resection, long-lasting surgery and poor lactate clearance (cLac) close to awakening from general anesthesia, all together may permit to classify the risk of post-operative adverse outcome after hepatic resection surgery.
Appendix
Available only for authorised users
Literature
1.
go back to reference Wei AC, Greig PD, Grant D, Taylor B, Langer B, Gallinger S. Survival after hepatic resection for colorectal metastases: a 10-year experience. Ann Surg Oncol. 2006;13(5):668–76.CrossRef Wei AC, Greig PD, Grant D, Taylor B, Langer B, Gallinger S. Survival after hepatic resection for colorectal metastases: a 10-year experience. Ann Surg Oncol. 2006;13(5):668–76.CrossRef
2.
go back to reference Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg. 1990s;191(1):38–46.CrossRef Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg. 1990s;191(1):38–46.CrossRef
3.
go back to reference Jarnagin WR, Gonen M, Fong Y, et al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg. 2002;236(4):397–406; discussion 406–7. Jarnagin WR, Gonen M, Fong Y, et al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg. 2002;236(4):397–406; discussion 406–7.
4.
go back to reference Sobol JB, Wunsch H. Triage of high-risk surgical patients for intensive care. Crit Care. 2011;15(2):217.CrossRef Sobol JB, Wunsch H. Triage of high-risk surgical patients for intensive care. Crit Care. 2011;15(2):217.CrossRef
5.
go back to reference Kristensen SD, Knuuti J, Saraste A, et al. 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on Non-cardiac Surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur Heart J. 2014;35(35):2383–431.CrossRef Kristensen SD, Knuuti J, Saraste A, et al. 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on Non-cardiac Surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur Heart J. 2014;35(35):2383–431.CrossRef
6.
go back to reference Wijeysundera DN, Pearse RM, et al. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet. 2018;391:2631–40.CrossRef Wijeysundera DN, Pearse RM, et al. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet. 2018;391:2631–40.CrossRef
7.
go back to reference Gawande AA, Kwaan MR, Regenbogen SE, Lipsitz SA, Zinner MJ. An Apgar score for surgery. J Am Coll Surg. 2007;204:201–8.CrossRef Gawande AA, Kwaan MR, Regenbogen SE, Lipsitz SA, Zinner MJ. An Apgar score for surgery. J Am Coll Surg. 2007;204:201–8.CrossRef
8.
go back to reference Tublin ME, Tessler FN, Murphy ME. Correlation between renal vascular resistance, pulse pressure, and the resistive index in isolated perfused rabbit kidneys. Radiology. 1999;213(1):258–64.CrossRef Tublin ME, Tessler FN, Murphy ME. Correlation between renal vascular resistance, pulse pressure, and the resistive index in isolated perfused rabbit kidneys. Radiology. 1999;213(1):258–64.CrossRef
9.
go back to reference Deruddre S, Cheisson G, Mazoit JX, Vicaut E, Benhamou D, Duranteau J. Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography. Intensive Care Med. 2007;33(9):1557–622.CrossRef Deruddre S, Cheisson G, Mazoit JX, Vicaut E, Benhamou D, Duranteau J. Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography. Intensive Care Med. 2007;33(9):1557–622.CrossRef
10.
go back to reference Brkljacić B, Drinković I, Sabljar-Matovinović M, et al. Intrarenal duplex Doppler sonographic evaluation of uni-lateral native kidney obstruction. J Ultrasound Med. 1994;13(3):197–204.CrossRef Brkljacić B, Drinković I, Sabljar-Matovinović M, et al. Intrarenal duplex Doppler sonographic evaluation of uni-lateral native kidney obstruction. J Ultrasound Med. 1994;13(3):197–204.CrossRef
13.
go back to reference Platt JF, Rubin JM, Ellis JH. Acute renal failure: possible role of duplex Doppler US in distinction between acute prerenal failure and acute tubular necrosis. Radiology. 1991;179(2):419–23.CrossRef Platt JF, Rubin JM, Ellis JH. Acute renal failure: possible role of duplex Doppler US in distinction between acute prerenal failure and acute tubular necrosis. Radiology. 1991;179(2):419–23.CrossRef
14.
go back to reference Corradi F, Brusasco C, Vezzani A, et al. Hemorrhagic shock in polytrauma patients: early detection with renal Doppler resistive index measurements. Radiology. 2011;260(1):112–8.CrossRef Corradi F, Brusasco C, Vezzani A, et al. Hemorrhagic shock in polytrauma patients: early detection with renal Doppler resistive index measurements. Radiology. 2011;260(1):112–8.CrossRef
16.
go back to reference Torzilli G, Procopio F, Botea F, et al. One-stage ultrasonographically guided hepatectomy for multiple bilobar colorectal metastases: a feasible and effective alternative to the 2-stage approach. Surgery. 2009;146(1):60–71.CrossRef Torzilli G, Procopio F, Botea F, et al. One-stage ultrasonographically guided hepatectomy for multiple bilobar colorectal metastases: a feasible and effective alternative to the 2-stage approach. Surgery. 2009;146(1):60–71.CrossRef
17.
go back to reference Dindo D, Demartines N, Clavien PA. Classification of surgical complications—a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.CrossRef Dindo D, Demartines N, Clavien PA. Classification of surgical complications—a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.CrossRef
18.
go back to reference Belghiti J, Clavien PA, Gadzijev E, et al. The Brisbane 2000 terminology of liver anatomy and resections. HPB. 2000;2:333–9.CrossRef Belghiti J, Clavien PA, Gadzijev E, et al. The Brisbane 2000 terminology of liver anatomy and resections. HPB. 2000;2:333–9.CrossRef
19.
go back to reference Nair AS. Surgical Apgar Score for predicting patient outcome after hepatopancreaticobiliary surgeries. Saudi J Anaesth. 2018;12(1):155–6.CrossRef Nair AS. Surgical Apgar Score for predicting patient outcome after hepatopancreaticobiliary surgeries. Saudi J Anaesth. 2018;12(1):155–6.CrossRef
20.
go back to reference Hosmer DW Jr, Lemeshow S, Sturdivant RX. Applied logistic regression. 3rd ed. Hoboken: Wiley; 2013.CrossRef Hosmer DW Jr, Lemeshow S, Sturdivant RX. Applied logistic regression. 3rd ed. Hoboken: Wiley; 2013.CrossRef
21.
go back to reference Kohl BA, Deutschman CS. The inflammatory response to surgery and trauma. Curr Opin Crit Care. 2006;12:325–32.CrossRef Kohl BA, Deutschman CS. The inflammatory response to surgery and trauma. Curr Opin Crit Care. 2006;12:325–32.CrossRef
25.
go back to reference Bossard G, Bourgoin P, Corbeau JJ, Huntzinger J, Beydon L. Early detection of postoperative acute kidney injury by Doppler renal resistive index in cardiac surgery with cardiopulmonary bypass. Br J Anaesth. 2011;107(6):891–8.CrossRef Bossard G, Bourgoin P, Corbeau JJ, Huntzinger J, Beydon L. Early detection of postoperative acute kidney injury by Doppler renal resistive index in cardiac surgery with cardiopulmonary bypass. Br J Anaesth. 2011;107(6):891–8.CrossRef
26.
go back to reference Devarajan P. Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury. Nephrology (Carlton). 2010;15(4):419–28.CrossRef Devarajan P. Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury. Nephrology (Carlton). 2010;15(4):419–28.CrossRef
27.
go back to reference Le Dorze M, Bouglé A, Deruddre S, Duranteau J. Renal Doppler ultrasound: a new tool to assess renal perfusion in critical illness. Shock. 2012;37(4):360–5.CrossRef Le Dorze M, Bouglé A, Deruddre S, Duranteau J. Renal Doppler ultrasound: a new tool to assess renal perfusion in critical illness. Shock. 2012;37(4):360–5.CrossRef
28.
go back to reference Schnell D, Deruddre S, Harrois A, et al. Renal resistive index better predicts the occurrence of acute kidney injury than cystatin C. Shock. 2012;38(6):592–7.CrossRef Schnell D, Deruddre S, Harrois A, et al. Renal resistive index better predicts the occurrence of acute kidney injury than cystatin C. Shock. 2012;38(6):592–7.CrossRef
29.
go back to reference Darmon M, Schortgen F, Vargas F, et al. Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients. Intensive Care Med. 2011;37(1):68–766.CrossRef Darmon M, Schortgen F, Vargas F, et al. Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients. Intensive Care Med. 2011;37(1):68–766.CrossRef
30.
go back to reference Tedesco MA, Natale F, Mocerino R, Tassinario G, Calabrò R. Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients. J Hum Hypertens. 2007;21(4):291–6.CrossRef Tedesco MA, Natale F, Mocerino R, Tassinario G, Calabrò R. Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients. J Hum Hypertens. 2007;21(4):291–6.CrossRef
31.
go back to reference Florczak E, Januszewicz M, Januszewicz A, et al. Relationship between renal resistive index and early target organ damage in patients with never treated essential hypertension. Blood Press. 2009;18(1–2):55–61.CrossRef Florczak E, Januszewicz M, Januszewicz A, et al. Relationship between renal resistive index and early target organ damage in patients with never treated essential hypertension. Blood Press. 2009;18(1–2):55–61.CrossRef
32.
go back to reference Schnell D, Camous L, Guyomarc’h S, et al. Renal perfusion assessment by renal Doppler during fluid challenge in sepsis. Crit Care Med. 2013;41(5):1214–20.CrossRef Schnell D, Camous L, Guyomarc’h S, et al. Renal perfusion assessment by renal Doppler during fluid challenge in sepsis. Crit Care Med. 2013;41(5):1214–20.CrossRef
33.
go back to reference Copeland GP, Jones D, Walters M. POSSUM: a scoring system for surgical audit. Br J Surg. 1991;78(3):355–60.CrossRef Copeland GP, Jones D, Walters M. POSSUM: a scoring system for surgical audit. Br J Surg. 1991;78(3):355–60.CrossRef
34.
go back to reference Khuri SF. The NSQIP. A new frontier in surgery. Surgery. 2005;138:837–43.CrossRef Khuri SF. The NSQIP. A new frontier in surgery. Surgery. 2005;138:837–43.CrossRef
35.
go back to reference Schnell D, Reynaud M, Venot M, et al. Resistive Index or color-Doppler semi-quantitative evaluation of renal perfusion by inexperienced physicians: results of a pilot study. Minerva Anestesiol. 2014;80(12):1273–81.PubMed Schnell D, Reynaud M, Venot M, et al. Resistive Index or color-Doppler semi-quantitative evaluation of renal perfusion by inexperienced physicians: results of a pilot study. Minerva Anestesiol. 2014;80(12):1273–81.PubMed
36.
go back to reference Darmon M, Schnell D, Zeni F. Doppler-based renal resistive index: a comprehensive review. In: Vincent JL, editor. Yearbook of intensive care and emergency medicine. Heidelberg: Springer; 2010. p. 331–338. Darmon M, Schnell D, Zeni F. Doppler-based renal resistive index: a comprehensive review. In: Vincent JL, editor. Yearbook of intensive care and emergency medicine. Heidelberg: Springer; 2010. p. 331–338.
37.
go back to reference Cazzaniga M, Salerno F, Visentin S, Cirello I, Donarini C, Cugno M. Increased flow-mediated vasodilation in cirrhotic patient with ascites: relationship with renal resistive index. Liver Int. 2008;28(10):1396–401.CrossRef Cazzaniga M, Salerno F, Visentin S, Cirello I, Donarini C, Cugno M. Increased flow-mediated vasodilation in cirrhotic patient with ascites: relationship with renal resistive index. Liver Int. 2008;28(10):1396–401.CrossRef
38.
go back to reference Umbro I, Tinti F, Fiacco F, et al. Resistive index and MELD-Na: nephrologic monitoring in cirrhotic patients awaiting liver transplantation. Transplant Proc. 2013;45(7):2676–9.CrossRef Umbro I, Tinti F, Fiacco F, et al. Resistive index and MELD-Na: nephrologic monitoring in cirrhotic patients awaiting liver transplantation. Transplant Proc. 2013;45(7):2676–9.CrossRef
Metadata
Title
Renal resistive index as a predictor of postoperative complications in liver resection surgery. Observational study
Authors
Enrico Giustiniano
Fabio Procopio
Emanuela Morenghi
Yari Gollo
Laura Rocchi
Nadia Ruggieri
Valeria Lascari
Guido Torzilli
Maurizio Cecconi
Publication date
01-08-2021
Publisher
Springer Netherlands
Published in
Journal of Clinical Monitoring and Computing / Issue 4/2021
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI
https://doi.org/10.1007/s10877-020-00529-4

Other articles of this Issue 4/2021

Journal of Clinical Monitoring and Computing 4/2021 Go to the issue