Top

Journal of Clinical Monitoring and Computing

Published in:

01-12-2018 | Letter to the Editor

In response to: phenylephrine and paradoxically increased muscle tissue oxygenation: is the mechanism related to local venoconstriction or augmented venous return?

Authors: H. Sørensen, A. H. Egesborg, J. H. Thomsen, A. S. P. Meyer, D. Terzic, L. Hilsted, J. Kjærgaard, J. P. Goetze, T. C. Barbosa, N. H. Secher

Published in: Journal of Clinical Monitoring and Computing | Issue 6/2018

Excerpt

We thank Prof. Hilary P. Grocott for his interest in the consequence of phenylephrine for muscle oxygenation as determined by near infrared spectroscopy (NIRS; SmO2) [1, 2]. Phenylephrine is an α-adrenergic agonist and we expected SmO2 to decrease in response to administration of phenylephrine but, as indicated by Prof. Grocott, veins are also sensitive to α-adrenergic stimulation. …

Grocott HP. Phenylephrine and paradoxically increased muscle tissue oxygenation: is the mechanism related to local venoconstriction or augmented venous return?. J Clin Monit Comput 2018. https://doi.org/10.1007/s10877-018-0102-y CrossRefPubMed

Sørensen H, Thomsen JH, Meyer AS, Terzic D, Hilsted L, Kjaergaard J, Goetze JP, Barbosa TC. Secher NH phenylephrine increases near-infrared spectroscopy determined muscle oxygenation in men. J Clin Monit Comput. 2017;31(6):1159–66.sCrossRef

Sørensen H, Secher NH. Rasmussen P. A note on arterial to venous oxygen saturation as reference for NIRS-determined frontal lobe oxygen saturation in healthy humans. Front Physiol. 2014;4:403.CrossRef

Truijen J, Kim YS, Krediet CT, Stok WJ, Kolgen RS, Colier WN, Secher NH, van Lieshout JJ. Orthostatic leg blood volume changes assessed by near-infrared spectroscopy. Exp Physiol. 2012;97(3):353–61.CrossRef

Egesborg AH, Olesen ND, Sørensen H. Secher NH phenylephrine increases near-infrared spectroscopy determined muscle oxygenation during head-up tilt. Abstract, summer meeting, Danish Cardiovascular Research Academy, Sandbjerg 2017.

Cannesson M, Jian Z, Chen G, Vu TQ, Hatib F. Effects of phenylephrine on cardiac output and venous return depend on the position of the heart on the Frank-Starling relationship. J Appl Physiol. 2012;113(2):281–9.CrossRef

Title: In response to: phenylephrine and paradoxically increased muscle tissue oxygenation: is the mechanism related to local venoconstriction or augmented venous return?
Authors: H. Sørensen
A. H. Egesborg
J. H. Thomsen
A. S. P. Meyer
D. Terzic
L. Hilsted
J. Kjærgaard
J. P. Goetze
T. C. Barbosa
N. H. Secher
Publication date: 01-12-2018
Publisher: Springer Netherlands
Published in: Journal of Clinical Monitoring and Computing / Issue 6/2018
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-018-0108-5

At a glance: The STEP trials

Springer Medicine

In response to: phenylephrine and paradoxically increased muscle tissue oxygenation: is the mechanism related to local venoconstriction or augmented venous return?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 6/2018

Cerebral oximetry during preoperative resuscitation in elderly patients with hip fracture: a prospective observational study

Volumetric and reflective device dead space of anaesthetic reflectors under different conditions

Impact of continuous non-invasive blood pressure monitoring on hemodynamic fluctuation during general anesthesia: a randomized controlled study

Non-invasive bladder volume measurement for the prevention of postoperative urinary retention: validation of two ultrasound devices in a clinical setting

Respiratory quotient estimations as additional prognostic tools in early septic shock

Comparison of cardiac output optimization with an automated closed-loop goal-directed fluid therapy versus non standardized manual fluid administration during elective abdominal surgery: first prospective randomized controlled trial