Top

Journal of Clinical Monitoring and Computing

Published in:

Open Access 01-08-2017 | Editorial

Digging into the microcirculation: the rush for gold may excavate apples and oranges

Authors: E. Christiaan Boerma, Thomas W. L. Scheeren

Published in: Journal of Clinical Monitoring and Computing | Issue 4/2017

Excerpt

The microcirculation is a central part of the cardiovascular system consisting of blood vessels with a diameter below 150 µm. Its main function is to exchange oxygen, carbon dioxide, nutrients, and other metabolites with the cells. The microcirculation of a healthy individual is characterized by a dense network of perfused capillaries with minimal heterogeneity, most of the capillaries being perfused even though flow in the various capillaries varies according to metabolic needs of the surrounding tissues. Adaptation to metabolic needs occurs by opening and closing capillaries, i.e. by adapting microcirculatory blood flow [1]. …

Scheeren TWL. Journal of Clinical Monitoring and Computing 2015 end of year summary: tissue oxygenation and microcirculation. J Clin Monit Comput. 2016;30:141–6. doi:10.1007/s10877-016-9846-4.CrossRefPubMedPubMedCentral

Elbers PWG, Ince C. Mechanisms of critical illness: classifying microcirculatory flow abnormalities in distributive shock. Crit Care. 2006;10:221. doi:10.1186/cc4969.CrossRefPubMedPubMedCentral

De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166:98–104.CrossRefPubMed

Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL, Arnold RC, Colilla S, Zanotti S, Hollenberg SM, Microcirculatory Alterations in Resuscitation and Shock Investigators. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med. 2007; 49:88–98, 98.e1. doi:10.1016/j.annemergmed.2006.08.021.

Hernandez G, Boerma EC, Dubin A, Bruhn A, Koopmans M, Edul VK, Ruiz C, Castro R, Pozo MO, Pedreros C, Veas E, Fuentealba A, Kattan E, Rovegno M, Ince C. Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients. J Crit Care. 2013;28:538.e9–14. doi:10.1016/j.jcrc.2012.11.022.CrossRef

Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med. 2004;32:1825–31.CrossRefPubMed

Tachon G, Harrois A, Tanaka S, Kato H, Huet O, Pottecher J, Vicaut E, Duranteau J. Microcirculatory alterations in traumatic hemorrhagic shock. Crit Care Med. 2014;42:1433–41. doi:10.1097/CCM.0000000000000223.CrossRefPubMed

Groner W, Winkelman JW, Harris AG, Ince C, Bouma GJ, Messmer K, Nadeau RG. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med. 1999;5:1209–12. doi:10.1038/13529.CrossRefPubMed

Goedhart PT, Khalilzada M, Bezemer R, Merza J, Ince C. Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express. 2007;15:15101–14.CrossRefPubMed

10.

De Backer D, Hollenberg S, Boerma C, Goedhart P, Büchele G, Ospina-Tascon G, Dobbe I, Ince C. How to evaluate the microcirculation: report of a round table conference. Crit Care. 2007;11:R101. doi:10.1186/cc6118.CrossRefPubMedPubMedCentral

11.

Dobbe JGG, Streekstra GJ, Atasever B, van Zijderveld R, Ince C. Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis. Med Biol Eng Comput. 2008;46:659–70. doi:10.1007/s11517-008-0349-4.CrossRefPubMedPubMedCentral

12.

Aykut G, Veenstra G, Scorcella C, Ince C, Boerma C. Cytocam-IDF (incident dark field illumination) imaging for bedside monitoring of the microcirculation. Intensive Care Med Exp. 2015;3:40. doi:10.1186/s40635-015-0040-7.CrossRefPubMed

13.

van Elteren HA, Ince C, Tibboel D, Reiss IKM, de Jonge RCJ. Cutaneous microcirculation in preterm neonates: comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging. J Clin Monit Comput. 2015;29:543–8. doi:10.1007/s10877-015-9708-5.CrossRefPubMedPubMedCentral

14.

Carsetti A, Aya HD, Pierantozzi S, Bazurro S, Donati A, Rhodes A, Cecconi M. Ability and efficiency of an automatic analysis software to measure microvascular parameters. J Clin Monit Comput. 2016;. doi:10.1007/s10877-016-9928-3.

15.

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, van der Voort PHJ, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Pattnaik R, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Tijssen JGP, Bakker J, Ince C, microSOAP Study Group. International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med. 2015;43:48–56. doi:10.1097/CCM.0000000000000553.CrossRefPubMed

16.

Pranskunas A, Pilvinis V, Dambrauskas Z, Rasimaviciute R, Planciuniene R, Dobozinskas P, Veikutis V, Vaitkaitis D, Boerma EC. Early course of microcirculatory perfusion in eye and digestive tract during hypodynamic sepsis. Crit Care. 2012;16:R83. doi:10.1186/cc11341.CrossRefPubMedPubMedCentral

17.

Tanaka S, Harrois A, Nicolaï C, Flores M, Hamada S, Vicaut E, Duranteau J. Qualitative real-time analysis by nurses of sublingual microcirculation in intensive care unit: the MICRONURSE study. Crit Care. 2015;19:388. doi:10.1186/s13054-015-1106-3.CrossRefPubMedPubMedCentral

Title: Digging into the microcirculation: the rush for gold may excavate apples and oranges
Authors: E. Christiaan Boerma
Thomas W. L. Scheeren
Publication date: 01-08-2017
Publisher: Springer Netherlands
Published in: Journal of Clinical Monitoring and Computing / Issue 4/2017
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-016-9935-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Digging into the microcirculation: the rush for gold may excavate apples and oranges

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 4/2017

A systematic review of pulse pressure variation and stroke volume variation to predict fluid responsiveness during cardiac and thoracic surgery

Electromyographic activation reveals cortical and sub-cortical dissociation during emergence from general anesthesia

Automated, continuous and non-invasive assessment of pulse pressure variations using CNAP® system

Sympatho-vagal balance, as quantified by ANSindex, predicts post spinal hypotension and vasopressor requirement in parturients undergoing lower segmental cesarean section: a single blinded prospective observational study

A novel multivariate STeady-state index during general ANesthesia (STAN)

Reliability of cardiac output measurements using LiDCOrapid™ and FloTrac/Vigileo™ across broad ranges of cardiac output values