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Journal of Clinical Monitoring and Computing
Published in: Journal of Clinical Monitoring and Computing 6/2015

01-12-2015 | Original Research

Early monitoring of ventriculostomy-related infections with procalcitonin in patients with ventricular drains

Authors: Amr S. Omar, Amr ElShawarby, Rajvir Singh

Published in: Journal of Clinical Monitoring and Computing | Issue 6/2015

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Abstract

Several factors are implicated in the increased vulnerability of multiple trauma victims to infection, especially in intensive care units. The incidence of EVD related infections ranges from 5 to 20 %. To assess the accuracy of serum procalcitonin (PCT) in predicting central nervous system (CNS) infection in patients with EVDs. Thirty-six adult patients with severe head trauma were enrolled in this prospective study, after exclusion of other causes of fever; patients were subjected to sampling of C-reactive protein (CRP), PCT, and cerebrospinal fluid (CSF) cultures every other day. Five patients developed ventriculostomy-related infections, and all had an elevated serum PCT concentration. Patients with negative CSF cultures had mean serum PCT <2.0 ng/ml, while patients with positive culture had early elevation of serum PCT with mean of 4.18 ng/ml, CRP did not show similar early changes. Patients who acquire CNS infection had prolonged length of stay in hospital and length of ventilation. In absence of other nosocomial infections, early high serum PCT concentrations appear to be a reliable indicator of bacterial CNS infection in patients with EVD.
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Metadata
Title
Early monitoring of ventriculostomy-related infections with procalcitonin in patients with ventricular drains
Authors
Amr S. Omar
Amr ElShawarby
Rajvir Singh
Publication date
01-12-2015
Publisher
Springer Netherlands
Published in
Journal of Clinical Monitoring and Computing / Issue 6/2015
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI
https://doi.org/10.1007/s10877-015-9663-1

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