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Journal of Assisted Reproduction and Genetics

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18-08-2023 | Preimplantation Genetic Diagnostics | Review

Factors associated with embryo mosaicism: a systematic review and meta-analysis

Authors: A Cascales, R Morales, A Castro, JA Ortiz, B Lledo, J Ten, A Bernabeu, R Bernabeu

Published in: Journal of Assisted Reproduction and Genetics | Issue 10/2023

Abstract

Purpose

Evaluate which factors are involved in the increased rate of mosaicism in embryos.

Methods

A systematic review and meta-analysis was performed. After an exhaustive search of the literature, a total of seven papers were included in the analysis. In addition, data collected from IVF cycles performed in our fertility clinic were also analysed. Day of biopsy, embryo quality, maternal and paternal age and seminal quality were the chosen factors to be studied.

Results

The results of the meta-analysis show that neither embryo quality nor seminal quality were related to mosaic embryo rate (OR: 1.09; 95% CI: 0.94–1.28 and OR: 1.10; 95% CI: 0.87–1.37, respectively). A positive association was observed for the variable “biopsy day” with embryos biopsied at day 6 or 7 having the highest rate of mosaicism (OR: 1.06; 95% CI: 1.01–1.11). In opposite to what happens with aneuploidy rate, which increases with maternal age, embryo mosaicism is higher in younger women (<34 years) rather than in older ones (≥34 years) (OR: 0.95; 95% CI: 0.92–0.98). However, for the “paternal age” factor, no association with mosaicism was found (OR: 1.04; 95% CI: 0.90–1.21).

Conclusions

With the present study, we can conclude that the factors related to the presence of mosaicism in embryos are the embryo biopsy day and maternal age. The rest of the studied factors showed no significant relationship with mosaicism. These results are of great importance as knowing the possible causes leading to mosaicism helps to improve the clinical results of reproductive treatments.

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Title: Factors associated with embryo mosaicism: a systematic review and meta-analysis
Authors: A Cascales
R Morales
A Castro
JA Ortiz
B Lledo
J Ten
A Bernabeu
R Bernabeu
Publication date: 18-08-2023
Publisher: Springer US
Keyword: Preimplantation Genetic Diagnostics
Published in: Journal of Assisted Reproduction and Genetics / Issue 10/2023
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-023-02914-9

At a glance: The STEP trials

Springer Medicine

Factors associated with embryo mosaicism: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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