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Journal of Assisted Reproduction and Genetics

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01-10-2019 | Infertility | Assisted Reproduction Technologies

ICSI does not offer any benefit over conventional IVF across different ovarian response categories in non-male factor infertility: a European multicenter analysis

Authors: Panagiotis Drakopoulos, Juan Garcia-Velasco, Ernesto Bosch, Christophe Blockeel, Michel de Vos, Samuel Santos-Ribeiro, Antonis Makrigiannakis, Herman Tournaye, Nikolaos P. Polyzos

Published in: Journal of Assisted Reproduction and Genetics | Issue 10/2019

Abstract

Purpose

To evaluate whether ICSI offers any benefit compared with IVF in different ovarian response categories in case of non-male factor infertility.

Methods

This is a retrospective multicenter analysis using individual patient data, conducted in 15 tertiary referral hospitals in Europe (1 center in Belgium and 14 in Spain). The study included the first cycle of all patients undergoing ovarian stimulation for IVF or ICSI in a GnRH antagonist protocol. Only patients having either IVF or ICSI for non-male factor infertility were included. Patients were divided into 4 groups based on their ovarian response as follows: group A, poor responders (1–3 oocytes); group B, suboptimal responders (4–9 oocytes); group C, normal responders (10–15 oocytes); group D, high responders (> 15 oocytes).

Results

In total, 4891 patients were analyzed, of whom 4227 underwent ICSI and 664 IVF. There was no significant difference for the insemination method (ICSI vs. IVF) used among the different ovarian response categories: 87% vs. 13%, 87% vs. 13%, 86% vs. 14%, 84% vs. 16%, for groups A, B, C, and D, respectively, p value = 0.35. Mean fertilization rates and embryo utilization rates were comparable between IVF and ICSI in the whole cohort. Fresh and cumulative LBR did not differ significantly for IVF and ICSI in poor, suboptimal, normal, and high responders.

Conclusion

There is no advantage of ICSI over IVF as insemination method for non-male factor infertility, irrespective of the ovarian response. The number of oocytes retrieved has no value for the selection of the insemination procedure in case of non-male infertility.

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Title: ICSI does not offer any benefit over conventional IVF across different ovarian response categories in non-male factor infertility: a European multicenter analysis
Authors: Panagiotis Drakopoulos
Juan Garcia-Velasco
Ernesto Bosch
Christophe Blockeel
Michel de Vos
Samuel Santos-Ribeiro
Antonis Makrigiannakis
Herman Tournaye
Nikolaos P. Polyzos
Publication date: 01-10-2019
Publisher: Springer US
Keywords: Infertility
ICSI
Infertility
Published in: Journal of Assisted Reproduction and Genetics / Issue 10/2019
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-019-01563-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

ICSI does not offer any benefit over conventional IVF across different ovarian response categories in non-male factor infertility: a European multicenter analysis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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