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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 4/2019

Open Access 01-04-2019 | ICSI | Assisted Reproduction Technologies

In assisted reproduction by IVF or ICSI, the rate at which embryos develop to the blastocyst stage is influenced by the fertilization method used: a split IVF/ICSI study

Authors: Barbara Speyer, Helen O’Neill, Wael Saab, Srividya Seshadri, Suzanne Cawood, Carleen Heath, Matthew Gaunt, Paul Serhal

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2019

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Abstract

Purpose

To compare in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) in regard to post-fertilization development and outcome with the purpose of ascertaining the most effective fertilization method for assisted reproduction.

Methods

A retrospective cohort study of 136 split IVF/ICSI cycles (where sibling oocytes are fertilized by two different methods using the same sperm sample).

Results

IVF-derived embryos developed to the blastocyst stage at a significantly faster rate than ICSI-derived embryos. There was no significant difference in fertilization or livebirth rates between the two fertilization methods.

Conclusions

For patients with sperm progressive motility ≥ 1.0 × 106/ml (who usually constitute the majority of patients), no significant difference between the two fertilization methods was found in regard to fertilization rate or livebirth rate. Remaining factors influencing choice between the two methods appear to be restricted to convenience, financial considerations and concern with regard to possible perpetuation of genetically linked infertility to future generations.
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Metadata
Title
In assisted reproduction by IVF or ICSI, the rate at which embryos develop to the blastocyst stage is influenced by the fertilization method used: a split IVF/ICSI study
Authors
Barbara Speyer
Helen O’Neill
Wael Saab
Srividya Seshadri
Suzanne Cawood
Carleen Heath
Matthew Gaunt
Paul Serhal
Publication date
01-04-2019
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 4/2019
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-018-1358-3

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Which embryo selection method should be offered to the patients?