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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 4/2018

Open Access 01-04-2018 | Technological Innovations

Preliminary human application of optical coherence tomography for quantification and localization of primordial follicles aimed at effective ovarian tissue transplantation

Authors: Seido Takae, Kosuke Tsukada, Ichiro Maeda, Naoki Okamoto, Yorino Sato, Haruhiro Kondo, Kiemi Shinya, Yuki Motani, Nao Suzuki

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2018

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Abstract

Purpose

The purpose of this study was to evaluate the possible clinical application of optical coherence tomography for assessing ovarian reserve in individual specimens of human ovarian tissue for fertility preservation.

Methods

Ovarian tissue examination by optical coherence tomography was performed before ovarian tissue cryopreservation. Three of the four subjects had hematological disease or cancer, and they faced a threat to their fertility due to impending chemotherapy. One patient underwent ovarian tissue extraction for in vitro activation of dormant follicles as fertility treatment.

Results

The current full-field optical coherence tomography technique can detect primordial follicles in non-fixed and non-embedded human ovarian tissue. These images are well correlated with histological evaluation and the ovarian reserve test, including follicle counts.

Conclusion

It was demonstrated that optical coherence tomography could assess localization of primordial follicles and ovarian reserve in specimens of non-fixed human ovarian cortex, although optimization for examination of human ovarian tissue is needed for clinical application. Additionally, this technique holds the possibility of assessing the ovarian reserve of patients with unevaluable ovarian reserve.

Trial registration number

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Metadata
Title
Preliminary human application of optical coherence tomography for quantification and localization of primordial follicles aimed at effective ovarian tissue transplantation
Authors
Seido Takae
Kosuke Tsukada
Ichiro Maeda
Naoki Okamoto
Yorino Sato
Haruhiro Kondo
Kiemi Shinya
Yuki Motani
Nao Suzuki
Publication date
01-04-2018
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 4/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-018-1166-9

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Commentary

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