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Journal of Assisted Reproduction and Genetics

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01-02-2018 | Editor's Commentary

The non-cell autonomy of human gametes

Author: David F. Albertini

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2018

Excerpt

Despite our efforts as taskmasters, we continue to search for that perfect pair of gametes to recombine on the hopeful way to embryo transfer; the outcome inadequacies of such searches remain poor in clinical terms. As ARTs evolved, the notion that gamete developmental proficiency would be evident in intrinsic morphological appearances or other extragametic (read niche) biomarkers of said gamete’s potential as embryo generators has settled deeply into the mindset of contemporary ART practitioners. …

Martin-DeLeon PA. Epididymosomes: transfer of fertility-modulating proteins to the sperm surface. Asian J Androl. 2015;17(5):720–5.PubMedPubMedCentral

Rowlison T, Ottinger MA, Comizzoli P. Key factors enhancing sperm fertilizing ability are transferred from the epididymis to the spermatozoa via epididymosomes in the domestic cat model. J Assist Reprod Genet. 2017. https://doi.org/10.1007/s10815-017-1083.PubMed

Sullivan R. Epididymosomes: role of extracellular microvesicles in sperm maturation. Front Biosci (Schol Ed). 2016;8:106–14.CrossRef

Reilly JN, McLaughlin EA, Stanger SJ, Anderson AL, Hutcheon K, Church K, et al. Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome. Sci Rep. 2016;6:31794.CrossRefPubMedPubMedCentral

Murta D, Batista M, Silva E, Trindade A, Henrique D, Duarte A, et al. Notch signaling in the epididymal epithelium regulates sperm motility and is transferred at a distance within epididymosomes. Andrology. 2016;4(2):314–27.CrossRefPubMed

Sun L, Li D, Song K, Wei J, Yao S, Li Z, et al. Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro. Sci Rep. 2017;7(1):2552.CrossRefPubMedPubMedCentral

Salamonsen LA, Evans J, Nguyen HP, Edgell TA. The microenvironment of human implantation: determinant of reproductive success. Am J Reprod Immunol. 2016;75(3):218–25.CrossRefPubMed

Albertini DF. Of exosomes and epididymsomes: how parental metabolism influences an embryos’ fate. J Assist Reprod Genet. 2016;33(3):301–2.CrossRefPubMedPubMedCentral

Title: The non-cell autonomy of human gametes
Author: David F. Albertini
Publication date: 01-02-2018
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 2/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-018-1139-z

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The non-cell autonomy of human gametes

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