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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 2/2018

01-02-2018 | Genetics

Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases

Authors: Larysa Y. Pylyp, Lyudmyla O. Spynenko, Nataliya V. Verhoglyad, Anna O. Mishenko, Dmytro O. Mykytenko, Valery D. Zukin

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2018

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Abstract

Purpose

The purpose of this study is to perform a retrospective analysis of types and frequencies of chromosomal abnormalities detected by conventional cytogenetic studies in first-trimester miscarriages after spontaneous conception and IVF.

Methods

Standard cytogenetic analysis of GTG-banded chromosomes obtained from products of conception (POCs): semi-direct and short-term cultured chorionic villi or long-term cultured fetal mesodermal cells.

Results

50.1% of first-trimester miscarriages in the studied group had chromosomal abnormalities: 59.7% of trisomies, 22% of poliploidies, 7.5% of monosomies, 7% of unbalanced structural abnormalities, and 3.8% of multiple aneuploidies. An increase in the frequency of chromosomally abnormal miscarriages was observed in the group of women above 40 when compared to groups of women under 35 (P < 0.05). No difference in frequencies and types of chromosomal abnormalities in POCs of miscarriages after ICSI and spontaneous conception was observed.

Conclusions

Approximately, 50% of first-trimester miscarriages have chromosomal abnormalities which can be detected by conventional cytogenetic analysis. The presence of chromosomal abnormality may explain the cause of miscarriage, improving the reproductive counseling and planning.
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Metadata
Title
Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases
Authors
Larysa Y. Pylyp
Lyudmyla O. Spynenko
Nataliya V. Verhoglyad
Anna O. Mishenko
Dmytro O. Mykytenko
Valery D. Zukin
Publication date
01-02-2018
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 2/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-017-1069-1

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