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Journal of Assisted Reproduction and Genetics

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01-12-2017 | Genetics

Endometriosis-associated infertility: GDF-9, AMH, and AMHR2 genes polymorphisms

Authors: Emily De Conto, Úrsula Matte, João Paolo Bilibio, Vanessa Krebs Genro, Carlos Augusto Souza, Delva Pereira Leão, João Sabino Cunha-Filho

Published in: Journal of Assisted Reproduction and Genetics | Issue 12/2017

Abstract

Purpose

The purpose of this paper is to determine whether there is a correlation between polymorphisms in the growth differentiation factor-9 (GDF-9) gene and anti-Müllerian hormone (AMH) gene and its receptor, AMHR2, and endometriosis-associated infertility.

Methods

This is a case-control study to evaluate whether there is a correlation between polymorphisms in the GDF-9 gene (SNPs determined by direct sequencing), AMH gene, AMHR2 (both SNPs determined by genotyping using TaqMan Allelic Discrimination), and endometriosis-associated infertility. The study included 74 infertile women with endometriosis and 70 fertile women (tubal ligation) as a control group.

Results

Patient age and the mean FSH levels were similar between the infertile with endometriosis and fertile without endometriosis groups. The frequency of genotypes between the groups for GDF-9 gene polymorphisms did not show statistical significance, nor did the AMHR2 gene polymorphism. However, the AMH gene polymorphism did show statistical significance, relating the polymorphic allele with infertility in endometriosis.

Conclusions

We demonstrate that an SNP in the AMH gene is associated with infertility in endometriosis, whereas several SNPs in the GDF-9 gene and the – 482A G SNP in the AMHR2 gene were found to be unrelated.

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Title: Endometriosis-associated infertility: GDF-9, AMH, and AMHR2 genes polymorphisms
Authors: Emily De Conto
Úrsula Matte
João Paolo Bilibio
Vanessa Krebs Genro
Carlos Augusto Souza
Delva Pereira Leão
João Sabino Cunha-Filho
Publication date: 01-12-2017
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 12/2017
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-1026-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Endometriosis-associated infertility: GDF-9, AMH, and AMHR2 genes polymorphisms

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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