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Journal of Assisted Reproduction and Genetics

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01-06-2017 | Reproductive Physiology and Disease

Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome

Authors: Esra Nur Tola, Dilek Ulusoy Karatopuk, Nadiye Koroglu, Merve Ergin, Hilmi Baha Oral

Published in: Journal of Assisted Reproduction and Genetics | Issue 6/2017

Abstract

Purpose

Polycystic ovary syndrome (PCOS) is the most common cause of ovulatory dysfunction and female infertility. The etiopathogenetic mechanisms of PCOS have been studied for many years, although exact causes remain unclear. It has been demonstrated that proteoglycan degradation by a disintegrin-like metalloproteinase with thrombospondin type motifs-1 (ADAMTS-1) is essential for ovulation and fertilization. The objective of our study is to analyze the levels of ADAMTS-1 and aggrecan in the follicular fluid (FF) of PCOS patients compared with normal ovulatory women and to determine whether these markers could be a predictor of in vitro fertilization (IVF) success in PCOS patients.

Methods

Women with PCOS (n = 21) and normal ovulatory controls (n = 22) undergoing IVF treatment were recruited. ADAMTS-1 and aggrecan levels were analyzed with enzyme-linked immunosorbent assay (ELISA) and compared between PCOS and normal ovulatory controls. The predictor effect of ADAMTS-1 and aggrecan on fertilization rate and implantation was evaluated.

Results

FF ADAMTS-1 and aggrecan levels increased in women with PCOS compared to controls. Elevated ADAMTS-1 levels but not aggrecan were related to increased implantation in PCOS.

Conclusion

Our study demonstrated that altered levels of ADAMTS-1 and aggrecan may have a partial role in the etiopathogenesis of PCOS, and ADAMTS-1 could be a predictive marker for implantation success in PCOS patients.

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Title: Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome
Authors: Esra Nur Tola
Dilek Ulusoy Karatopuk
Nadiye Koroglu
Merve Ergin
Hilmi Baha Oral
Publication date: 01-06-2017
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 6/2017
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-0913-7

At a glance: The STEP trials

Springer Medicine

Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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