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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 9/2016

01-09-2016 | Genetics

Correlation of normal-range FMR1 repeat length or genotypes and reproductive parameters

Authors: Bat-Sheva L. Maslow, Stephanie Davis, Lawrence Engmann, John C. Nulsen, Claudio A. Benadiva

Published in: Journal of Assisted Reproduction and Genetics | Issue 9/2016

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Abstract

Purpose

This study aims to ascertain whether the length of normal-ranged CGG repeats on the FMR1 gene correlates with abnormal reproductive parameters.

Methods

We performed a retrospective, cross-sectional study of all FMR1 carrier screening performed as part of routine care at a large university-based fertility center from January 2011 to March 2014. Correlations were performed between normal-range FMR1 length and baseline serum anti-Müllerian hormone (AMH), cycle day 3 follicle stimulating hormone (FSH), ovarian volumes (OV), antral follicle counts (AFC), and incidence of diminished ovarian reserve (DOR), while controlling for the effect of age.

Results

Six hundred three FMR1 screening results were collected. One subject was found to be a pre-mutation carrier and was excluded from the study. Baseline serum AMH, cycle day 3 FSH, OV, and AFC data were collected for the 602 subjects with normal-ranged CGG repeats. No significant difference in median age was noted amongst any of the FMR1 repeat genotypes. No significant correlation or association was found between any allele length or genotype, with any of the reproductive parameters or with incidence of DOR at any age (p > 0.05). However, subjects who were less than 35 years old with low/low genotype were significantly more likely to have below average AMH levels compared to those with normal/normal genotype (RR 3.82; 95 % CI 1.38–10.56).

Conclusions

This large study did not demonstrate any substantial association between normal-range FMR1 repeat lengths and reproductive parameters.
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Metadata
Title
Correlation of normal-range FMR1 repeat length or genotypes and reproductive parameters
Authors
Bat-Sheva L. Maslow
Stephanie Davis
Lawrence Engmann
John C. Nulsen
Claudio A. Benadiva
Publication date
01-09-2016
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 9/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-016-0732-2

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