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Journal of Assisted Reproduction and Genetics

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01-07-2016 | Letter to Editor

The PlA2 variant of the platelet glycoprotein IIIa as a genetic risk factor for IVF implantation failure: accumulating evidence

Authors: Nikolaos Vlachadis, Nikolaos Vrachnis, Emmanuel Economou

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2016

Excerpt

We read with great interest the recent article of Patounakis et al. [1] who examined the potential role of nine genetic thrombophilic factors in in vitro fertilization (IVF) outcome. Even though the authors came to the conclusion that the thrombophilic single nucleotide polymorphisms (SNPs) which were evaluated, individually or cumulatively, do not have any significant effect, an important clinical finding, the correlation of the genetic polymorphism PIA1/PIA2 (T1565C-Leu33Pro) (rs5918) of the platelet glycoprotein llla (Gpllla) gene with implantation failure after IVF embryo-transfer (IVF-ET failure), was overlooked. …

Patounakis G, Bergh E, Forman EJ, Tao X, Lonczak A, Franasiak JM, et al. Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients. J Assist Reprod Genet. 2016;33:67–73.CrossRefPubMed

Di Nisio M, Rutjes AW, Ferrante N, Tiboni GM, Cuccurullo F, Porreca E. Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis. Blood. 2011;118:2670–8.CrossRefPubMed

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Qublan HS, Eid SS, Ababneh HA, Amarin ZO, Smadi AZ, Al-Khafaji FF, et al. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod. 2006;21:2694–8.CrossRefPubMed

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Floyd CN, Mustafa A, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for myocardial infarction: a meta-analysis. PLoS One. 2014;9, e101518.CrossRefPubMedPubMedCentral

Floyd CN, Ellis BH, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for stroke: a systematic review and meta-analysis. PLoS One. 2014;9, e100239.CrossRefPubMedPubMedCentral

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10.

Vlachadis N, Tsamadias V, Kouskouni E, Vitoratos N, Hatziveis K, Economou E. Genetic heterogeneity of platelet glycoproteins Ia and IIIa is associated with in vitro fertilisation implantation failure. J Obstet Gynaecol. 2015;35:733–6.CrossRefPubMed

11.

Ivanov P, Tsvyatkovska T, Konova E, Komsa-Penkova R. Inherited thrombophilia and IVF failure: the impact of coagulation disorders on implantation process. Am J Reprod Immunol. 2012;68:189–98.CrossRefPubMed

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Coulam CB, Jeyendran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations are risk factors for implantation failure. Reprod Biomed Online. 2006;12:322–7.CrossRefPubMed

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Floyd CN, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa in relation to efficacy of antiplatelet drugs: a systematic review and meta-analysis. Br J Clin Pharmacol. 2014;77:446–57.CrossRefPubMedPubMedCentral

14.

Vlachadis N, Tsamadias V, Economou E. Aspirin to improve IVF unexplained implantation rates: time for an individualized approach. Reprod Biomed Online. 2014;28:133.CrossRefPubMed

Title: The PlA2 variant of the platelet glycoprotein IIIa as a genetic risk factor for IVF implantation failure: accumulating evidence
Authors: Nikolaos Vlachadis
Nikolaos Vrachnis
Emmanuel Economou
Publication date: 01-07-2016
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 7/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0722-4

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