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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 4/2015

01-04-2015 | Assisted Reproduction Technologies

Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study

Authors: Charalampos Siristatidis, Maria Aggeliki Komitopoulou, Andreas Makris, Afrodite Sialakouma, Mitrodora Botzaki, George Mastorakos, George Salamalekis, Stefano Bettocchi, Giles Anthony Palmer

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2015

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Abstract

Purpose

To compare the outcomes of embryos selected via time lapse monitoring (TLM) versus those selected with conventional methods of selection in subfertile women undergoing ICSI.

Methods

The study population (239 women) was classified into two groups, based on the monitoring method used: Group 1 (TLM) and Group 2 (conventional monitoring). Groups were compared according to the clinical and ICSI cycle characteristics and reproductive outcomes, while transfers were performed at day 2 or 3. Subgroup analyses were performed, in women of both groups according to age and clinical parameters, and in embryos of Group 1 based on their cellular events.

Results

There was a statistically significant difference between the two study groups with regard to the outcome parameters, favoring Group 1 and especially in women >40 years of age. No differences were found in subgroup analyses in participants of both groups, regarding the stimulation protocol used, number of the oocytes retrieved and type of subfertility, while in Group 1 the percentages of “in range” cellular events were higher in certain divisions in ages 35–40, non-smokers, and the GnRH-agonist group, and in embryos that resulted in pregnancy.

Conclusion

Morphokinetic parameters of early embryo development via TLM are related to the characteristics of subfertile patients and associated with ICSI outcomes.
Appendix
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Metadata
Title
Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study
Authors
Charalampos Siristatidis
Maria Aggeliki Komitopoulou
Andreas Makris
Afrodite Sialakouma
Mitrodora Botzaki
George Mastorakos
George Salamalekis
Stefano Bettocchi
Giles Anthony Palmer
Publication date
01-04-2015
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 4/2015
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-015-0436-z

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