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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 4/2015

01-04-2015 | Review

Contemporary evidence on the physiological role of reactive oxygen species in human sperm function

Authors: Stefan S. Du Plessis, Ashok Agarwal, Jacques Halabi, Eva Tvrda

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2015

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Abstract

Reactive oxygen species (ROS) play an important role in male fertility. Overproduction of reactive oxygen species (ROS) has been associated with a variety of male fertility complications, including leukocytospermia, varicocele and idiopathic infertility. The subsequent oxidative insult to spermatozoa can manifest as insufficient energy metabolism, lipid peroxidation and DNA damage, leading to loss of motility and viability. However, various studies have demonstrated that physiological amounts of ROS play important roles in the processes of spermatozoa maturation, capacitation, hyperactivation and acrosome reaction. It is therefore crucial to define and understand the delicate oxidative balance in male reproductive cells and tissues for a better understanding of both positive as well as negative impact of ROS production on the fertilizing ability. This review will discuss the specific physiological roles, mechanisms of action and effects that ROS have on the acquisition of structural integrity and physiological activity of spermatozoa.
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Metadata
Title
Contemporary evidence on the physiological role of reactive oxygen species in human sperm function
Authors
Stefan S. Du Plessis
Ashok Agarwal
Jacques Halabi
Eva Tvrda
Publication date
01-04-2015
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 4/2015
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-014-0425-7

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