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Journal of Assisted Reproduction and Genetics

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01-10-2014 | Genetics

The VEGF +405 G>C 5' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women

Authors: Praveen Guruvaiah, Suresh Govatati, Tumu Venkat Reddy, Dakshayani Lomada, Mamata Deenadayal, Sisinthy Shivaji, Manjula Bhanoori

Published in: Journal of Assisted Reproduction and Genetics | Issue 10/2014

Abstract

Purpose

The aim of this study was to investigate the association between two common single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene (−460C/T and +405G/C) and polycystic ovary syndrome (PCOS) risk in south Indian women.

Methods

This study involves clinically confirmed PCOS patients (n = 126) and non-PCOS controls (n = 130) of south Indian origin (Dravidian linguistic group). Genotyping of the VEGF gene −460C/T and +405G/C SNPs were performed by PCR and sequencing analysis. Haplotype frequencies for multiple loci and the standardized disequilibrium coefficient (D') for pairwise linkage disequilibrium (LD) were assessed by Haploview Software.

Results

The frequencies of +405G/G genotype (P = 0.03) and +405G alleles (P = 0.006) were significantly higher in patients compared to controls. Whereas the genotype and allele frequencies of −460C/T SNP were not significantly different between patients and controls. In addition, LD analysis revealed no significant difference between patients and controls.

Conclusion

Our findings suggest that the VEGF +405G/C polymorphism may constitute an inheritable risk factor for PCOS in south Indian women.

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Title: The VEGF +405 G>C 5' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women
Authors: Praveen Guruvaiah
Suresh Govatati
Tumu Venkat Reddy
Dakshayani Lomada
Mamata Deenadayal
Sisinthy Shivaji
Manjula Bhanoori
Publication date: 01-10-2014
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 10/2014
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-014-0310-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The VEGF +405 G>C 5' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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