Top

Journal of Assisted Reproduction and Genetics

Published in:

01-07-2014 | Genetics

Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort

Authors: Shuai Li, Kai Fang, Wenjian Wang, Yonghua Hu, Dafang Chen

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2014

Abstract

Purpose

To investigate interactions on gestational age among two environmental risk factors and four maternal genetic polymorphisms: organic solvents, passive smoking, CYP1A1 rs4646903 (MspI), EPHX1 rs2234922 (His139Arg), GSTT1 and PON2 rs12026 (Ala148Gly).

Methods

A pregnant women cohort was conducted at Beijing Yanshan Petrochemical Corporation, and 1,097 mothers with live singleton births were included in analysis. Generalized Multifactor Dimensionality Reduction (GMDR) method was used to explore interactions among these factors with adjustment for important potential confounders. Multiple linear regression models were used to estimate the association of interaction with gestational age.

Results

A three-factor model of organic solvents, GSTT1 and PON2 rs12026 had the highest testing balanced accuracy (57.05 %) and best cross-validation consistency (10/10). Compared with organic solvents unexposed mothers with GSTT1 non-null genotype and PON2 rs12026 CC genotype, organic solvents exposed mothers with GSTT1 null genotype and PON2 rs12026 CG + GG genotype had the largest reduction in gestational age (−0.36 weeks, 95%CI: −0.70 to −0.02). The significant reductions in different groups were from 0.24 weeks to 0.36 weeks.

Conclusions

Maternal genetic susceptibility GSTT1 and PON2 rs12026 could significantly modify the association of organic solvents with gestational age.

Callaghan WM, MacDorman MF, Rasmussen SA, Qin C, Lackritz EM. The contribution of preterm birth to infant mortality rates in the United States. Pediatrics. 2006;118(4):1566–73. doi:10.1542/peds.2006-0860.PubMedCrossRef

Crider KS, Whitehead N, Buus RM. Genetic variation associated with preterm birth: a HuGE review. Genet Med. 2005;7(9):593–604. doi:10.109701.gim.0000187223.69947.db.PubMedCrossRef

Llop S, Ballester F, Estarlich M, Esplugues A, Rebagliato M, Iniguez C. Preterm birth and exposure to air pollutants during pregnancy. Environ Res. 2010;110(8):778–85. doi:10.1016/j.envres.2010.09.009.PubMedCrossRef

Forand SP, Lewis-Michl EL, Gomez MI. Adverse birth outcomes and maternal exposure to trichloroethylene and tetrachloroethylene through soil vapor intrusion in New York State. Environ Health Perspect. 2012;120(4):616–21. doi:10.1289/ehp.1103884.PubMedCentralPubMedCrossRef

Ahmed P, Jaakkola JJ. Exposure to organic solvents and adverse pregnancy outcomes. Hum Reprod. 2007;22(10):2751–7.PubMedCrossRef

Slama R, Thiebaugeorges O, Goua V, Aussel L, Sacco P, Bohet A, et al. Maternal personal exposure to airborne benzene and intrauterine growth. Environ Health Perspect. 2009;117(8):1313–21. doi:10.1289/ehp.0800465.PubMedCentralPubMedCrossRef

Miyake Y, Tanaka K, Arakawa M. Active and passive maternal smoking during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study. BMC Pregnancy Childbirth. 2013. doi:10.1186/1471-2393-13-157.PubMedCentralPubMed

Salmasi G, Grady R, Jones J, McDonald SD. Environmental tobacco smoke exposure and perinatal outcomes: a systematic review and meta-analyses. Acta Obstet Gynecol Scand. 2010;89(4):423–41. doi:10.3109/00016340903505748.PubMedCrossRef

Stillerman KP, Mattison DR, Giudice LC, Woodruff TJ. Environmental exposures and adverse pregnancy outcomes: a review of the science. Reprod Sci. 2008;15(7):631–50. doi:10.1177/1933719108322436.PubMedCrossRef

10.

Wang X, Zuckerman B, Pearson C, Kaufman G, Chen C, Wang G, et al. Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. JAMA. 2002;287(2):195–202.PubMedCrossRef

11.

Nukui T, Day RD, Sims CS, Ness RB, Romkes M. Maternal/newborn GSTT1 null genotype contributes to risk of preterm, low birthweight infants. Pharmacogenetics. 2004;14(9):569–76.PubMedCrossRef

12.

Wu T, Hu Y, Chen C, Yang F, Li Z, Fang Z, et al. Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women. Am J Epidemiol. 2007;166(3):313–22. doi:10.1093/aje/kwm090.PubMedCrossRef

13.

Chen D, Hu Y, Chen C, Yang F, Fang Z, Wang L, et al. Polymorphisms of the paraoxonase gene and risk of preterm delivery. Epidemiology. 2004;15(4):466–70.PubMedCrossRef

14.

Tsai HJ, Liu X, Mestan K, Yu Y, Zhang S, Fang Y, et al. Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways. Hum Genet. 2008;123(4):359–69. doi:10.1007/s00439-008-0485-9.PubMedCentralPubMedCrossRef

15.

Wang X, Chen D, Niu T, Wang Z, Wang L, Ryan L, et al. Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction. Am J Epidemiol. 2000;152(8):693–700.PubMedCrossRef

16.

Occupational exposure to benzene, Docket no.H-059c, 29 CFR part 1910 (1985).

17.

Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N, Watanabe J. Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett. 1990;263(1):131–3.PubMedCrossRef

18.

Hassett C, Aicher L, Sidhu JS, Omiecinski CJ. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Mol Genet. 1994;3(3):421–8.PubMedCrossRef

19.

Nelson HH, Wiencke JK, Christiani DC, Cheng TJ, Zuo ZF, Schwartz BS, et al. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis. 1995;16(5):1243–5.PubMedCrossRef

20.

Sanghera DK, Aston CE, Saha N, Kamboh MI. DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease. Am J Hum Genet. 1998;62(1):36–44. doi:10.1086/301669.PubMedCentralPubMedCrossRef

21.

Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, et al. A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet. 2007;80(6):1125–37. doi:10.1086/518312.PubMedCentralPubMedCrossRef

22.

Chen D, Cho SI, Chen C, Wang X, Damokosh AI, Ryan L, et al. Exposure to benzene, occupational stress, and reduced birth weight. Occup Environ Med. 2000;57(10):661–7.PubMedCentralPubMedCrossRef

23.

Qin X, Wu Y, Wang W, Liu T, Wang L, Hu Y, et al. Low organic solvent exposure and combined maternal-infant gene polymorphisms affect gestational age. Occup Environ Med. 2008;65(7):482–7. doi:10.1136/oem.2007.032474.PubMedCrossRef

24.

Moore JH, Ritchie MD. The challenges of whole-genome approaches to common diseases. JAMA. 2004;291(13):1642–3. doi:10.1001/jama.291.13.1642.PubMedCrossRef

25.

Chevrier C, Dananche B, Bahuau M, Nelva A, Herman C, Francannet C, et al. Occupational exposure to organic solvent mixtures during pregnancy and the risk of non-syndromic oral clefts. Occup Environ Med. 2006;63(9):617–23. doi:10.1136/oem.2005.024067.PubMedCentralPubMedCrossRef

26.

Kumar S. Occupational exposure associated with reproductive dysfunction. J Occup Health. 2004;46(1):1–19.PubMedCrossRef

27.

Erexson GL, Wilmer JL, Kligerman AD. Sister chromatid exchange induction in human lymphocytes exposed to benzene and its metabolites in vitro. Cancer Res. 1985;45(6):2471–7.PubMed

28.

Yager JW, Eastmond DA, Robertson ML, Paradisin WM, Smith MT. Characterization of micronuclei induced in human lymphocytes by benzene metabolites. Cancer Res. 1990;50(2):393–9.PubMed

29.

Lazutka JR, Lekevicius R, Dedonyte V, Maciuleviciute-Gervers L, Mierauskiene J, Rudaitiene S, et al. Chromosomal aberrations and sister-chromatid exchanges in Lithuanian populations: effects of occupational and environmental exposures. Mutat Res. 1999;445(2):225–39.PubMedCrossRef

30.

Kovacic P, Jacintho JD. Reproductive toxins: pervasive theme of oxidative stress and electron transfer. Curr Med Chem. 2001;8(7):863–92.PubMedCrossRef

31.

Murata M, Tsujikawa M, Kawanishi S. Oxidative DNA damage by minor metabolites of toluene may lead to carcinogenesis and reproductive dysfunction. Biochem Biophys Res Commun. 1999;261(2):478–83. doi:10.1006/bbrc.1999.1041.PubMedCrossRef

32.

Schroder KR, Wiebel FA, Reich S, Dannappel D, Bolt HM, Hallier E. Glutathione-S-transferase (GST) theta polymorphism influences background SCE rate. Arch Toxicol. 1995;69(7):505–7.PubMedCrossRef

33.

Xu X, Wiencke JK, Niu T, Wang M, Watanabe H, Kelsey KT, et al. Benzene exposure, glutathione S-transferase theta homozygous deletion, and sister chromatid exchanges. Am J Ind Med. 1998;33(2):157–63.PubMedCrossRef

34.

Seidegard J, Vorachek WR, Pero RW, Pearson WR. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc Natl Acad Sci U S A. 1988;85(19):7293–7.PubMedCentralPubMedCrossRef

35.

Sprenger R, Schlagenhaufer R, Kerb R, Bruhn C, Brockmoller J, Roots I, et al. Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. Pharmacogenetics. 2000;10(6):557–65.PubMedCrossRef

36.

Ng CJ, Wadleigh DJ, Gangopadhyay A, Hama S, Grijalva VR, Navab M, et al. Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J Biol Chem. 2001;276(48):44444–9. doi:10.1074/jbc.M105660200.PubMedCrossRef

37.

Horke S, Witte I, Wilgenbus P, Kruger M, Strand D, Forstermann U. Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation. 2007;115(15):2055–64. doi:10.1161/circulationaha.106.681700.PubMedCrossRef

38.

Stoltz DA, Ozer EA, Recker TJ, Estin M, Yang X, Shih DM, et al. A common mutation in paraoxonase-2 results in impaired lactonase activity. J Biol Chem. 2009;284(51):35564–71. doi:10.1074/jbc.M109.051706.PubMedCentralPubMedCrossRef

Title: Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort
Authors: Shuai Li
Kai Fang
Wenjian Wang
Yonghua Hu
Dafang Chen
Publication date: 01-07-2014
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 7/2014
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-014-0256-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 7/2014

Two different microarray technologies for preimplantation genetic diagnosis and screening, due to reciprocal translocation imbalances, demonstrate equivalent euploidy and clinical pregnancy rates

CYP11A1 microsatellite (tttta)n polymorphism in PCOS women from South India

Human embryo cryopreservation: one-step slow freezing does it all?

Candidate gene expression patterns in rabbit preimplantation embryos developed in vivo and in vitro

Genetic study of Hormad1 and Hormad2 with non-obstructive azoospermia patients in the male Chinese population

“Been hit twice”: a novel bi-allelic heterozygous mutation in LHCGR