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Journal of Assisted Reproduction and Genetics

Published in:

01-02-2012 | Gonad Physiology and Disease

Impaired Gremlin 1 (GREM1) expression in cumulus cells in young women with diminished ovarian reserve (DOR)

Authors: Sangita Jindal, Keri Greenseid, Dara Berger, Nanette Santoro, Lubna Pal

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2012

Abstract

Purpose

A symbiotic relationship between ovarian granulosa cells (GC) and the developing oocyte is critical. Genetic modulations in GC’s can lead to reproductive insufficiency, highlighting the role of GC’s in reproductive competence. Utilizing gene expression analyses in cumulus GC’s, we attempt to enhance our understanding of mechanisms that may contribute to poor reproductive capacity in young women with diminished ovarian reserve (DOR).

Methods

We measured gremlin 1 (GREM1) gene expression in GC’s from infertile women <38 years undergoing in vitro fertilization in the context of DOR.

Results

GREM1, a member of the differential screening-selected gene aberrative in neuroblastoma (DAN) family of genes known for its highly regulated expression pattern during folliculogenesis and a downstream effecter of oocyte-derived growth and differentiation factor 9, was down-regulated 3-fold (−3.08) in women with DOR versus control; down-regulation was confirmed by qRT-PCR (−4.02).

Conclusion

This is the first demonstration linking differential expression of Gremlin with etiology of infertility in women.

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Title: Impaired Gremlin 1 (GREM1) expression in cumulus cells in young women with diminished ovarian reserve (DOR)
Authors: Sangita Jindal
Keri Greenseid
Dara Berger
Nanette Santoro
Lubna Pal
Publication date: 01-02-2012
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 2/2012
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9684-8

At a glance: The STEP trials

Springer Medicine

Impaired Gremlin 1 (GREM1) expression in cumulus cells in young women with diminished ovarian reserve (DOR)

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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